Takasaki Ichiro

タカサキイチロウ | Takasaki Ichiro

Affiliation and department：
Job title：准教授
Homepage URL (1)： http://www3.u-toyama.ac.jp/yakuri/index.html

Research field (4)： Neuropathology , Pharmacology , Pharmaceuticals - health and biochemistry , Neuroscience - general

Research keywords (24)： PAC1受容体 , PACAP , 帯状疱疹後神経痛 , 帯状疱疹痛 , 帯状庖疹 , 神経栄養因子 , 帯状疱疹 , 帯状庖疹後神経痛 , アロディニア , 抗うつ薬 , IE62 , デルタメトリン , 新経栄養因子 , 脳由来神経栄養因子 , Galectin-3 , 遺伝子発現 , 血小板由来増殖因子 , T細胞 , 細胞分化 , 細胞 , 神経幹細胞 , HLA遺伝子 , マウス , 疼痛

Research theme for competitive and other funds (22)：

2022 - 2025 掻痒疾患における中枢および末梢PACAP受容体シグナル伝達の比較解析
2021 - 2024 スプライシング異常細胞を排除する「細胞の品質管理機構」の解明
2021 - 2024 新規Nr4a1小分子拮抗薬の創薬~癌も痛みも抑える新しい薬となるか?
2020 - 2023 Pathophysiological significance of neuron-astrocyte implication of PACAP on stress-induced emotional disorder
2019 - 2022 Exploring new molecular to depression vulnerability formation in striatum

2019 - 2022 Dose PACAP-PAC1 receptor signaling contribute to itch transmission ?

2019 - 2022 Pathophysiology of left ventricular noncompaction: focus on the importance of the downstream pathway of the transcription factor TBX5

2018 - 2021 Development of new analgesics based on spinal cord Cyr61-integrin binding inhibition

2015 - 2018 Clarification of vasculitis in Kawasaki disease; focusing on the endothelial microparticles

2014 - 2017 Elucidation of the mechanisms of chronic pain by PAC1 receptor and drug discovery.

2012 - 2014 Development of new antidepressants from pyrethroid insecticide deltamethrin.

2011 - 2012 Mechanism of Genome Damage Response Induced by Ultrasoun

2010 - 2012 Elucidation of Molecular Mechanism of Cell Death induced by Radiation, Hyperthermia and Ultrasound for Cancer Therapy

2009 - 2011 Identification of the exercise not for bone formation but for bone absorption suppression and investigation of the underlying mechanisms

2009 - 2010 Investigation of the mechanisms by which antibody to VZV IE62 protein augments mechanical allodynia

2008 - 2010 Functional analysis of PDGF inducing neural stem cell differentiation.

2007 - 2009 Role of T cells in the onset of postherpetic neuralgia.

2007 - 2009 Development of testicular cell system with cell-cell interactions

2007 - 2008 The role of BDNF/trkB signaling in the transition to postherpetic neuralgia

2005 - 2006 急性帯状疱疹痛と帯状疱疹後神経痛の発症におよぼす神経栄養因子の役割

不死化細胞を用いた生体組織機能の再構築

モデルマウスを用いた帯状疱疹痛および帯状疱疹後神経痛発症機序の解明

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Papers (145)：

Ichiro Takasaki, Arata Inoue, Aoi Yoshida, Kimiyasu Shiraki, Yoshimi Kitada, Saori Arai. Fosphenytoin alleviates subacute herpetic neuralgia and postherpetic neuralgia in mice. RPS Pharmacy and Pharmacology Reports. 2023
Junko Shibato, Fumiko Takenoya, Michio Yamashita, Ravi Gupta, Cheol Woo Min, Sun Tae Kim, Ai Kimura, Ichiro Takasaki, Motohide Hori, Seiji Shioda, et al. OMICS Analyses Unraveling Related Gene and Protein-Driven Molecular Mechanisms Underlying PACAP 38-Induced Neurite Outgrowth in PC12 Cells. International journal of molecular sciences. 2023. 24. 4
Daisuke Ihara, Hiroki Tanabe, Ichiro Takasaki, Akiko Tabuchi. Endogenous SOLOIST/MRTFB i4, a neuronal isoform of MKL2/MRTFB, positively and negatively regulates SRF target immediate early genes in Neuro-2a cells. Biological and Pharmaceutical Bulletin. 2023. 46. 8. 1141-1144
Yuki Kambe, Masafumi Youkai, Kohei Hashiguchi, Yoshimune Sameshima, Ichiro Takasaki, Atsuro Miyata, Takashi Kurihara. Spinal Astrocyte-Neuron Lactate Shuttle Contributes to the Pituitary Adenylate Cyclase-Activating Polypeptide/PAC1 Receptor-Induced Nociceptive Behaviors in Mice. Biomolecules. 2022. 12. 12
Sisca Ucche, Satoru Yokoyama, Marija Mojic, Kohei Oki, Chikako Ohshima, Haruka Tsuihiji, Ichiro Takasaki, Hideaki Tahara, Yoshihiro Hayakawa. GSTA4 governs melanoma immune resistance and metastasis. Molecular cancer research : MCR. 2022

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MISC (28)：

山下道生, 柴藤淳子, RANDEEP Rakwal, 平林敬浩, 千葉義彦, 高崎一朗, 塩田清二, 竹ノ谷文子. Analysis of the molecular mechanism of neurite outgrowth in PC12 cells by neuropeptide PACAP. 日本薬学会年会要旨集(Web). 2023. 143rd
上田千裕, 神野奈緒子, 須藤航, 平林敬浩, 竹ノ谷文子, 塩田清二, 高崎一朗, 酒井寛泰, 千葉義彦. アレルギー性喘息モデルマウスの気管支平滑筋におけるPACAP受容体Adcyaplr1発現の減少. 日本薬学会年会要旨集. 2019. 139年会. 3. 72-72
上田千裕, 神野奈緒子, 須藤航, 平林敬浩, 竹ノ谷文子, 塩田清二, 高崎一朗, 酒井寛泰, 千葉義彦. アレルギー性喘息モデルマウスの気管支平滑筋におけるPACAP受容体Adcyaplr1発現の減少. 日本薬学会年会要旨集. 2019. 139年会. 3. 72-72
古澤之裕, 趙慶利, 小川良平, 田渕圭章, 高崎一朗, 近藤隆. 低強度パルス超音波照射による細胞内DNA 二本鎖切断の誘発と細胞応答. 日本ソノケミストリー学会誌. 2018. 12. 1-8
福地守, 前畑陽祐, 和泉宏謙, 田中亜由美, 井上蘭, 森寿, 高崎一朗, 竹森洋, 田渕明子, 津田正明. GPCR活性化によるNMDAレセプター/カルシニューリン/CRTC1/CREB経路を介したBDNF遺伝子発現誘導. 日本薬学会年会要旨集(CD-ROM). 2015. 135年会. 3. 78-78

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Patents (5)：

Education (1)：

- 2003 Toyama Medical and Pharmaceutical University

Professional career (1)：

Ph.D.

Work history (1)：

2014 - University of Toyama

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