- 2024 - 2027 ヒト化マウスを用いたドナー特異的抗体産生核酸の同定・機能解明と診断治療への応用
- 2024 - 2026 ヒトnaive B細胞から抗原特異的抗体産生細胞をin vitroで作成する画期的手法の開発
- 2023 - 2026 ヒト乳歯歯髄幹細胞を用いた膵島オルガノイドによる画期的膵島移植プロトコールの開発
- 2024 - 2025 抗体関連型拒絶反応におけるimmunogenetic peptideの機序解明
- 2024 - 2025 Single cell解析によるヒト間葉系幹細胞の新規免疫抑制メカニズムの解明
- 2024 - 2025 機械学習による多機能性B細胞の同定とその臨床応用
- 2023 - 2024 IVIgによる獲得免疫増強機構の解明
- 2023 - 2024 Single cell RNA sequence解析とT細胞受容体レパトア解析を組み合わせた新たな臓器移植後のDSA産生予測モデルの開発
- 2023 - 2024 小児臓器移植後の持続 EBV-DNA 血症に対するアロ感染免疫応答の基盤研究と臨床応用
- 2021 - 2024 ヒト化マウスによるドナー特異的抗体産生免疫プロファイリングの解明と個別化医療
- 2021 - 2024 非翻訳RNAに着目したCNI腎症早期発見システムの構築
- 2021 - 2023 Identification of Indirect Alloreactive T-Cells and Application to Monitoring of anti-Donor Antibody Sensing
- 2020 - 2023 Identification and control of follicular helper T cell clonotype related to donor specific HLA antibody production
- 2020 - 2023 From treatment to prevention: development of innovative immune regulation based on epitope/paratope analysis
- 2022 - 2023 RP105を介した抗原特異的抗体産生ヒトB細胞取得とその活性化メカニズムの解明
- 2021 - 2022 anti-RP105による効率的な抗原特異的抗体産生ヒトB細胞取得
- 2019 - 2022 Improvement of BK virus monitoring system in renal transplantation with the aim of graft long-term survival.
- 2020 - 2021 de novo DSA産生に影響を及ぼす, レシピエントHLA class II・ドナーpeptideの複合体
- 2018 - 2021 A multifaceted approach to HLA antibody-producing B cells for donor-specific antibody (DSA) regulation
- 2019 - 2020 慢性腎不全・移植腎におけるAutophagy制御と腎保護効果の検証
- 2019 - 2020 de novo DS産生制御のためのIndirect Alloresponseに特化した先制的免疫モニタリング
- 2019 - 2020 長期生着を目指したIndividual immune monitoringの構築
- 2019 - 2020 Autophagy活性化による腎臓病克服のための基礎研究
- 2019 - 2020 ドナー特異的抗体産生細胞の同定と、その制御法の開発
- 2018 - 2020 Introduction of precision medicine in renal transplantation: attempt to overcome HLA mismatch by TCR/BCR control
- 2019 - 2020 ドナー特異的アロ応答性T細胞の同定とクローン追跡による免疫反応の把握
- 2019 - 臓器移植を革新する免疫プロファイリングによる個別化医療の開発
- 2016 - 2019 Introduction of preventive and preemptive medicine against chronic antibody-mediated rejection for long-term graft survival
- 2016 - 2019 Development of immunological risk-benefit analysis and antibody treatment in ABO blood group incompatible kidney transplantation
- 2017 - 2019 HLA / A / B antibodies and endothelial cell responses that generate T cell subpopulation a new innovation in antibody-positive transplantation
- 2015 - 2017 Diversity analysis of antibody function and development of strategy to overcome antibody-mediate rejection: Establishment of pig model for ABO/HLA-incompatibility
- 2016 - 2017 内皮細胞 HLA の発現抑制シグナルの同定と薬剤探索
- 2015 - 2016 抗体関連型傷害抵抗を誘導するシグナル伝達
- 2013 - 2016 Comprehensive study on control of chronic antibody-mediated rejection after renal transplantation
- 2013 - 2016 Analysis of pleiotropic property of thrombomodulin and development of therapeutic strategy using thrombomodulin in transplantation
- 2014 - 2016 The prevention against chronic antibody mediated rejection on graft endothelial
- 2012 - 2015 Practical strategies for treatment of antibody mediated chronic rejection with inherent immune system
- 2014 - 2015 抗体関連型拒絶反応抵抗性獲得を可能にするシグナル伝達経路の同定とそ の診断
- 2012 - 2014 Development of in vitro culture for peripheral B cell differentiation into plasma cell
- 2012 - 2013 The identification of HLA class II DR associated molecules contributing to Accommodation
- 2010 - 2012 Development of pre-transplant assessments that predict AntibodyMediated Rejection(AMR)
- 2011 - 2011 薬力学および免疫機能モニタリングによる臓器移植患者の包括的支援体制の構築
- 2010 - 2011 The study on signal transduction to reduce the risk of antibody mediated chronic rejection
- 2009 - 2011 Establishment of a new evaluation method of post-transplant immune tolerance by donor-specific regulatory T cell analysis
- 2008 - 2010 Dynamic analysis of antigen, antibody, complement, inflammation and coagulation related to rejection, accommodation and tolerance
- 2008 - 2010 Individualization of Immunosuppressive Therapy Using Pharmacodynamics, Immunology and Molecular Biology
- 2008 - 2009 The Study of the signaling pathway on the endothelial cells after antibody-antigen binding.
Show all
IXA
, TTS
, 日本異種移植研究会
, THE JAPANESE SOCIETY FOR IMMUNOLOGY
, JAPANESE SOCIETY FOR HISTOCOMPATIBILITY AND IMMUNOGENETICS
, THE JAPANESE SOCIETY FOR ORGAN PRESERVATION AND BIOLOGY
, THE JAPAN SOCIETY FOR TRANSPLANTATION
, 日本免疫治療学会