2019 - 2021 Development and application of disease-specific protein targeting system
2018 - 2021 test
2018 - 2021 Functional analysis of the cell polarity regulatory complex Exocyst-Par3 in mammary epithelial cells
2015 - 2019 Reversible interconversin of mammary epithelial cells by EGF ligands
2016 - 2019 Epithelial and mesenchymal properties of mammary cells: role of kinase signaling and kinase inhibitor(Fostering Joint International Research)
2016 - 2018 Fluctuation of ectodomain shedding and the emersion of cancer cell heterogeneity
2014 - 2016 Study on the fluctuation of ectodomain shedding and its application to predict cancer cell dynamics
2012 - 2015 Regulation of ectodomian shedding by ADAM17 and remnant signaling
2012 - 2015 Role of growth factor and cytokine singaling in the determination of mammary epithelial cell characteristics
2010 - 2011 Molecular mechanism of auto-translocation of membrane anchored EGFR ligand into the nuclear membrane and its diagnostic application of cancer
2010 - 2011 Analysis of the machinery of ectodomain shedding and its possible role for the action of HB-EGF
2008 - 2010 Functional analysis of carboxy-terminal peptide signaling of pro-amphiregulin and pro-epiregulin
2008 - 2009 Role of the membrane-anchored growth factor in the cell cycle regulation of cancer stem cells
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Papers (31):
Shinya Sato, Megumi Miyazaki, Shinji Fukuda, Yukiko Mizutani, Yoichi Mizukami, Shigeki Higashiyama, Shintaro Inoue. Human TMEM2 is not a catalytic hyaluronidase, but a regulator of hyaluronan metabolism via HYBID (KIAA1199/CEMIP) and HAS2 expression. The Journal of biological chemistry. 2023. 299. 6. 104826-104826
Jun Muto, Shinji Fukuda, Kenji Watanabe, Xiuju Dai, Teruko Tsuda, Takeshi Kiyoi, Kenji Kameda, Ryosuke Kawakami, Hideki Mori, Ken Shiraishi, et al. Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21. Communications Biology. 2023. 6. 1
Felix Seefried, Lucia Haller, Shinji Fukuda, Aranya Thongmao, Nadja Schneider, Jochen Utikal, Shigeki Higashiyama, Anja Katrin Bosserhoff, Silke Kuphal. Nuclear AREG affects a low-proliferative phenotype and contributes to drug resistance of melanoma. International journal of cancer. 2022. 151. 12. 2244-2264
Honami Sugimoto, Shinji Fukuda, Satoru Yokawa, Miki Hori, Hotsuna Ninomiya, Takuma Sato, Ken Miyazawa, Tatsushi Kawai, Tadahide Furuno, Satoshi Inouye, et al. Visualization of osteocalcin and bone morphogenetic protein 2 (BMP2) secretion from osteoblastic cells by bioluminescence imaging. Biochemical and biophysical research communications. 2022. 635. 203-209
Hironao Nakayama, Hidetaka Ohnuki, Masako Nakahara, Hisayo Nishida-Fukuda, Tomohisa Sakaue, Shinji Fukuda, Shigeki Higashiyama, Yuki Doi, Masahiro Mitsuyoshi, Takashi Okimoto, et al. Inactivation of axon guidance molecule netrin-1 in human colorectal cancer by an epigenetic mechanism. Biochemical and Biophysical Research Communications. 2022. 611. 146-150
Yoshinori Ohno, Mitsuhito Koizumi, Hironao Nakayama, Takao Watanabe, Masashi Hirooka, Yohei Koizumi, Yoshio Tokumoto, Taira Kuroda, Shinji Fukuda, Shigeki Higashiyama, et al. Down-regulated acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) has a role in suppression of apoptosis, and is associated with poor prognosis in patients with hepatocellular carcinoma. HEPATOLOGY. 2016. 64. 358A-359A