2019 - 2021 Development and application of disease-specific protein targeting system
2018 - 2021 test
2018 - 2021 Functional analysis of the cell polarity regulatory complex Exocyst-Par3 in mammary epithelial cells
2015 - 2019 Reversible interconversin of mammary epithelial cells by EGF ligands
2016 - 2019 Epithelial and mesenchymal properties of mammary cells: role of kinase signaling and kinase inhibitor(Fostering Joint International Research)
2016 - 2018 Fluctuation of ectodomain shedding and the emersion of cancer cell heterogeneity
2014 - 2016 Study on the fluctuation of ectodomain shedding and its application to predict cancer cell dynamics
2012 - 2015 Regulation of ectodomian shedding by ADAM17 and remnant signaling
2012 - 2015 Role of growth factor and cytokine singaling in the determination of mammary epithelial cell characteristics
2010 - 2011 Molecular mechanism of auto-translocation of membrane anchored EGFR ligand into the nuclear membrane and its diagnostic application of cancer
2010 - 2011 Analysis of the machinery of ectodomain shedding and its possible role for the action of HB-EGF
2008 - 2010 Functional analysis of carboxy-terminal peptide signaling of pro-amphiregulin and pro-epiregulin
2008 - 2009 Role of the membrane-anchored growth factor in the cell cycle regulation of cancer stem cells
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Papers (32):
Hotsuna Ninomiya, Shinji Fukuda, Hisayo Nishida-Fukuda, Yuto Shibata, Takuma Sato, Yuko Nakamichi, Midori Nakamura, Nobuyuki Udagawa, Ken Miyazawa, Takahiro Suzuki. Osteoprotegerin secretion and its inhibition by RANKL in osteoblastic cells visualized using bioluminescence imaging. Bone. 2024. 117319-117319
Shinya Sato, Megumi Miyazaki, Shinji Fukuda, Yukiko Mizutani, Yoichi Mizukami, Shigeki Higashiyama, Shintaro Inoue. Human TMEM2 is not a catalytic hyaluronidase, but a regulator of hyaluronan metabolism via HYBID (KIAA1199/CEMIP) and HAS2 expression. The Journal of biological chemistry. 2023. 299. 6. 104826-104826
Jun Muto, Shinji Fukuda, Kenji Watanabe, Xiuju Dai, Teruko Tsuda, Takeshi Kiyoi, Kenji Kameda, Ryosuke Kawakami, Hideki Mori, Ken Shiraishi, et al. Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21. Communications Biology. 2023. 6. 1
Felix Seefried, Lucia Haller, Shinji Fukuda, Aranya Thongmao, Nadja Schneider, Jochen Utikal, Shigeki Higashiyama, Anja Katrin Bosserhoff, Silke Kuphal. Nuclear AREG affects a low-proliferative phenotype and contributes to drug resistance of melanoma. International journal of cancer. 2022. 151. 12. 2244-2264
佐藤伸哉, 増田愛美, 宮崎恵, 水谷有紀子, 福田信治, 東山繁樹, 井上紳太郎. Human TMEM2 is not a hyaluronidase, but rather a regulator that increases high-molecular-weight hyaluronan. 日本結合組織学会学術大会抄録集. 2020. 52nd. 64-64
Yoshinori Ohno, Mitsuhito Koizumi, Hironao Nakayama, Takao Watanabe, Masashi Hirooka, Yohei Koizumi, Yoshio Tokumoto, Taira Kuroda, Shinji Fukuda, Shigeki Higashiyama, et al. Down-regulated acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) has a role in suppression of apoptosis, and is associated with poor prognosis in patients with hepatocellular carcinoma. HEPATOLOGY. 2016. 64. 358A-359A