Ozawa Koichiro

オザワコウイチロウ | Ozawa Koichiro

Affiliation and department：
Job title： Professor

Research field (1)： Pharmacology

Research theme for competitive and other funds (21)：

2021 - 2024 マスト細胞機能における小胞体ストレスの役割解明と新規アレルギー治療標的の探索
2019 - 2023 Elucidation of the strategy towards the healthy life expectancy stretching by the use of big data
2018 - 2021 ER stress-induced leptin resistance and epigenetic mechanisms in regulating obesity
2015 - 2018 Elucidation of novel therapeutics of endoplasmic reticulum stress-related disease targeting aldehyde dehydrogenase
2010 - 2012 Development of novel drug for obesity targeting endoplasmic reticulum stress

2001 - 2002 Development of a new type of infrared laser-spectromicroscope and its application to analysis of molecular mechanisms in cells and tissues.

1999 - 2000 Development of a new type of infrared laser-spectromicroscope and its application to analysis of molecular dynamics in cells and tissues.

1997 - 1999 Development of a new type of laser-spectromicroscope and its application to analysis of molecular dynamics in cells.

1997 - 1998 ピロリ菌のホスホリパーゼ〜胃潰瘍・胃癌発症のニュートリガー〜

1997 - 1998 マルチフォーカス立体ビデオ顕微鏡の開発と細胞内情報伝達機構解明への応用

1997 - 1998 Development of A Chromato-video Spectro-Nanoscope and Establishment of Zeptmol Separation Base

1997 - 1998 Development of A Fiber Nano-scope with Molecular Trapping and its Application to the Analysis of Molecular Mechanism of Allergy

1996 - 1996 マルチプローブ蛍光顕微鏡の開発と細胞内情報伝達機構解明への応用

1995 - 1996 Development of Video Nanoscopes Using Crossed Laser Beams for Tracing of Drug Molecules

1995 - 1995 マルチスクリーン顕微鏡の開発と高時間分解での薬理解析への応用

1994 - 1995 Development of Capillary Electrophoresis under Crossed Super Magnetic Field

1994 - 1994 クロマト・ビデオスコープによる分離過程の解明および高機能クロマトグラフィーの開発

1994 - 1994 生きた細胞が見えるレーザー蛍光偏光解消顕微鏡の開発と細胞動態解析への応用

1993 - 1994 Development of Nano-space Video Microscopy and its Application to the Analysis of New Pharmacological Dyanamics

1993 - 1993 高分解能ビデオ顕微システムによるリセプター脱感作の動態解析

1992 - 1993 Development of X-ray-and Chemi-luminescence Video-Microscopy and its Application to the Analysis of Biodynamics in Micro Region

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Papers (289)：

Kyosuke Yazawa, Mieko Nakashima, Tadashi Nakagawa, Yuhki Yanase, Yukari Yoda, Koichiro Ozawa, Toru Hosoi. Pancreatic β cell-secreted factor FGF23 attenuates Alzheimer's disease-related amyloid β-induced neuronal death. PNAS Nexus. 2024. 4. 1
Toru Hosoi, Kyosuke Yazawa, Michihiro Imada, Akari Tawara, Chihiro Tohda, Yasuyuki Nomura, Koichiro Ozawa. Alkannin Attenuates AmyloidβAggregation and Alzheimer’s Disease Pathology. Molecular Pharmacology. 2023. 103. 5. 266-273
Preninka, Arini Isnani, Kuriya, Karen, Yazawa, Kyosuke, Yoshii, Michiko, Yanase, Yuhki, Jockers, Ralf, Dam, Julie, Hosoi, Toru, Ozawa, Koichiro. Homocysteine causes neuronal leptin resistance and endoplasmic reticulum stress. PLOS ONE. 2022. 17. 12. e0278965-e0278965
Tanaka, Keigo, Kuramoto, Kohei, Nakagawa, Tadashi, Nomura, Yasuyuki, Ozawa, Koichiro, Hosoi, Toru. COOH-terminal fragment of APP interacts with p62, forms an aggregate, and induces autophagic degradation in Alzheimer's cell model. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2022. 323. 6. C1633-C1641
Abd El-Hafeez, Amer Ali, Marzouk, Hala Mohamed M., Abdelhamid, Mohamed A. A., Khalifa, Hazim O., Hasanin, Tamer H. A., Habib, Ahmed G. K., Abdelwahed, Fatma Mahmoud, Barakat, Fatma M., Bastawy, Eslam M., Abdelghani, Eman M. B., et al. Anti-cancer Effect of Hyoscyamus muticus Extract via Its Activation of Fas/FasL-ASK1-p38 Pathway. BIOTECHNOLOGY AND BIOPROCESS ENGINEERING. 2022. 27. 5. 807-819

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MISC (21)：

Toru Hosoi, Rie Yamaguchi, Kikuko Noji, Takaaki Kayano, Kohei Mori, Koichiro Ozawa. Flurbiprofen ameliorated endoplasmic reticulum stress by interacting with aldehyde dehydrogenase. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 200P-200P
Yaichiro Kotake, Midori Isomura, Kyoichi Masuda, Masatsugu Miyara, Katsuhiro Okuda, Shigeyoshi Samizo, Seigo Sanoh, Toru Hosoi, Koichiro Ozawa, Shigeru Ohta. Tributyltin-induced endoplasmic reticulum stress and its mechanism. TOXICOLOGY LETTERS. 2013. 221. S173-S173
Yosuke Yamawaki, Manabu Fuchikami, Shigeru Morinobu, Masahiro Segawa, Tomoya Matsumoto, Koichiro Ozawa, Shigeto Yamawaki. Biological mechanism in antidepressant-like effect of sodium butyrate (HDAC inhibitor). JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 68P-68P
Rie Yamaguchi, Toru Hosoi, Sachiko Baba, Keisuke Toyoda, Kikuko Noji, Koichiro Ozawa. Exploration of a new class of anti-obesity agents which targets ER stress. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 226P-226P
Keisuke Toyoda, Toru Hosoi, Koichiro Ozawa. A novel compound ameliorating leptin resistance induced by endoplasmic reticulum stress in obesity. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 226P-226P

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Books (1)：

薬学総論 1.薬剤師としての基本的資質
東京化学同人 2015 ISBN:9784807917006

Lectures and oral presentations (9)：

Harmonization of pharmaceutical education in the world - A PROJECT COMMISSIONED TO PSJ FROM THE MEXT
(138th Annual Meeting of the Pharmaceutical Society of Japan 2018)
Comparing the pharmacy education between Japan and the foreign countries.
(137th Annual Meeting of the Pharmaceutical Society of Japan 2017)
Possible involvement of 4-hydroxy-2-nonenal on development of leptin resistance.
(The 90th Annual Meeting of the Japanese Pharmacological Society 2017)
Accreditation for pharmaceutical education in Japan.
(7rd Asian Association of Schools of Pharmacy 2015)
Accreditation of Pharmacy School in Japan.
(7TH Asian Association of Schools of Pharmacy (AASP) 2015)

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Professional career (1)：

Doctor of Philosophy in Pharmaceutical Science (Hiroshima University)

Work history (1)：

1999/04/01 - 2002/03/31 Hiroshima University

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