Rchr
J-GLOBAL ID：200901012808966030
Update date: Feb. 10, 2025
Kaneda Atsushi
カネダ アツシ | Kaneda Atsushi
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
https://www.m.chiba-u.ac.jp/class/moloncol/
Research field (4)：
Digestive surgery
, Tumor biology
, Genomics
, Virology
Research keywords (2)：
Epigenetics
, Cancer
Research theme for competitive and other funds (31)：
- 2024 - 2027 Elucidation of molecular mechanisms of ecDNA-mediated resistance acquisition in rare cancers and development of novel therapeutic targets
- 2024 - 2027 肺移植後の慢性移植肺機能不全に対する抗線維化治療の開発
- 2022 - 2025 Molecular mechanism of biliary tract carcinomas arising from patients with pancreaticobiliary malfunction
- 2021 - 2024 Establishment of standard precision diagnosis methodology for lung cancer surgery using respiratory endoscopy technology.
- 2021 - 2024 Transporter-targeted drug development against urological cancers by utilizing liquid biopsy and AI
- 2020 - 2023 Establishment of aminoacid transporter directed prostate cancer therapy based on the liquid biopsy
- 2020 - 2023 和漢薬からのエピゲノムを標的とする新規抗癌薬の探索及び作用機序の解明
- 2020 - 2023 Overcoming castration-resistant prostate cancer targeting androgen receptor and epigenome modifications
- 2020 - 2022 Development of novel region-selective epigenetic inhibitors against gastroenterological cancer
- 2019 - 2022 Elucidation of epigenomic regulation by chromosome segregation factor and identification of novel therapeutic target for leukemia
- 2019 - 2022 Clarification of mechanism of gastric tumorigenesis based on cancer stratification and development of novel therapeutic strategy
- 2019 - 2021 Functional redundancy of H3K4 methyltransferase family on epigenetic regulation in leukemia
- 2018 - 2021 The study of epigenetic regulation in peripheral immune cells associated with onset and remission of allergic rhinitis.
- 2018 - 2021 Mechanisms underlying renal injury and hypertension in adult period caused by abnormalities of tissue stem cell memory by malnutrition in fetal period.
- 2018 - 2020 Development of region-specific inhibitors against epigenomic aberrations critical for gastrointestinal tumorigenesis
- 2017 - 2020 Development of diagnosis and treatment system using respiratory endoscopy to promote precision medicine
- 2017 - 2020 Development of a Targeted T Cell Epitope Search System in Lung Cancer Patients Responding to Immunotherapy.
- 2017 - 2020 DNA analysis in lung cancer with idiopathic pulmonary fibrosis Gene analysis in lung cancer with idiopathic pulmonary fibrosis
- 2017 - 2019 Roles of TET family in dynamic epigenomic alteration induced by EB virus infection
- 2017 - 2019 Development of cancer suicide gene therapy using RNA trans-splicing technology
- 2017 - 2019 Genetic Profiling in murine orthotopic lung transplantation model of chronic lung allograft dysfunction
- 2016 - 2019 Stratification of gastric cancer and identification of molecular mechanism of gastric tumorigenesis based on aberrant DNA methylation profile
- 2016 - 2018 Development of platform for cancer epigenetic therapy by region-specific inhibition of epigenomic alteration
- 2014 - 2018 Development of multiplex biomarker testing and drug sensitivity testing using transbronchial biopsy samples.
- 2014 - 2017 Selective modification of histone methylation using DNA binding-small molecules
- 2014 - 2016 Analysis on alterated chromatin status of viral genome in the host cells.
- 2011 - 2013 癌遺伝子活性化が誘導する分泌蛋白環境の癌化防御における役割とその異常による癌化
- 2010 - 2012 Stratification of gastroenterological tumors by genome-wide analysis of DNA methylation alteration.
- 2009 - 2012 細胞老化のエピジェネティクスとその破綻による発癌機構
- 2007 - 2009 High-resolution epigenome analysis of cancer of the digestive system using tiling array
- 2000 - 2004 Identification of genes silenced in human gastric cancers
Show all
Papers (193)：
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Masahiro Takikawa, Airi Nakano, Jayaraman Krishnaraj, Yuko Tabata, Yuzo Watanabe, Atsushi Okabe, Yukiko Sakaguchi, Ryoji Fujiki, Ami Mochizuki, Tomoko Tajima, et al. Extrinsic induction of apoptosis and tumor suppression via the p53-Reprimo-Hippo-YAP/TAZ-p73 pathway. Proceedings of the National Academy of Sciences of the United States of America. 2025. 122. 6. e2413126122
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Yuki Yamanashi, Shinpei Takamaru, Atsushi Okabe, Satoshi Kaito, Yuto Azumaya, Yugo R. Kamimura, Kenzo Yamatsugu, Tomoya Kujirai, Hitoshi Kurumizaka, Atsushi Iwama, et al. Chemical catalyst manipulating cancer epigenome and transcription. Nature Communications. 2025. 16. 1
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Ryo Hatano, Xilin Zhang, Eunyoung Lee, Atsushi Kaneda, Tomoaki Tanaka, Takashi Miki. Mosaic ablation of pancreatic β-cells induces de-differentiation and repetitive proliferation of residual β-cells in adult mice. iScience. 2024. 110656-110656
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Takayuki Hoshii, Sota Kikuchi, Tomoya Kujirai, Takeshi Masuda, Tomoko Ito, Satoshi Yasuda, Makoto Matsumoto, Bahityar Rahmutulla, Masaki Fukuyo, Takeshi Murata, et al. BOD1L mediates chromatin binding and non-canonical function of H3K4 methyltransferase SETD1A. Nucleic acids research. 2024
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Takashi Kumagai, Arifumi Iwata, Hiroki Furuya, Kodai Kato, Atsushi Okabe, Yosuke Toda, Mizuki Kanai, Lisa Fujimura, Akemi Sakamoto, Takahiro Kageyama, et al. A distal enhancer of GATA3 regulates Th2 differentiation and allergic inflammation. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 27. e2320727121
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MISC (109)：
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蔡庭偉, 高根希世子, 山口貴世志, 池上恒雄, 合田良政, 清松知充, 矢野秀朗, 福世真樹, 関元昭, 金田篤志, et al. Analysis of genome-wide DNA methylation in pseudomyxoma peritonei originated from appendiceal cancer. 日本癌学会学術総会抄録集(Web). 2023. 82nd
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菅元泰, 千葉哲博, 大山広, 高地祐輔, 臼井源紀, 遠山翔大, 山田奈々, 杉原地平, 大内麻愉, 沖津恒一郎, et al. 扁平上皮癌成分を有する退形成性膵癌に対して遺伝子変異プロファイルを検討した一例. 膵臓(Web). 2023. 38. 3
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寧萌, 星居孝之, 林香菜子, 和泉真太郎, 朱天慧, 松本真, 眞野恭伸, 縄井バハテヤリラヒムトラ, 福世真樹, 金田篤志. Functional Analysis of H3K4 Methyltransferase Promoting Gastric Cancer Progression. 日本消化器癌発生学会総会プログラム・抄録集. 2022. 33rd
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蔡庭偉, 高根希世子, 山口貴世志, 池上恒雄, 合田良政, 清松知充, 矢野秀朗, 福世真樹, 関元昭, 金田篤志, et al. Analysis of genome-wide DNA methylation in pseudomyxoma peritonei originated from appendiceal cancer. 日本癌学会学術総会抄録集(Web). 2022. 81st
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蔡庭偉, 高根希世子, 山口貴世志, 池上恒雄, 合田良政, 清松知充, 矢野秀朗, 福世真樹, 関元昭, 金田篤志, et al. 虫垂及び卵巣原発腹膜偽粘液腫の網羅的DNAメチル化解析. 日本癌学会学術総会抄録集(Web). 2021. 80th
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Education (2)：
- 2000 - 2004 東京大学大学院 医学系研究科 博士課程
- 1987 - 1994 The University of Tokyo Faculty of Medicine School of Medicine
Professional career (2)：
Work history (7)：
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