Rchr
J-GLOBAL ID：200901012916846890
Update date: Oct. 02, 2024
Mishima Tatsuya
ミシマ タツヤ | Mishima Tatsuya
Affiliation and department：
Job title：
Associate Professor
Research field (4)：
Clinical pharmacy
, Physiology
, Anesthesiology
, Neuroscience - general
Research keywords (27)：
Ultrasound neuromodulation
, 包括脳ネットワーク
, ミトコンドリア
, 膜電位
, 神経細胞死
, 脳虚血
, アポトーシス
, ATP
, 脳神経疾患
, 細胞死
, membrane potential
, OGD
, 脳・神経
, vesicle transport
, 膜電位依存性色素
, 細胞内カルシウム
, Golgi
, ischemia
, necrosis
, 自閉症
, 神経科学
, mitohocndria
, spreading depression
, apoptosis
, neuronal death
, 神経生理学
, Neurophysiology
Research theme for competitive and other funds (13)：
- 2022 - 2025 Involvement of astrocytes in the development of febrile seizures due to STX1B haploinsufficiency
- 2016 - 2019 Role of syntaxin1 in glial cells on the interaction between neurons and glial cells
- 2013 - 2016 Role for ER stress responsive ER-Golgi SNARE in processing of Alzheimer`s disease-related protein and autophagy
- 2012 - 2015 Functional difference between syntaxin1 isoforms in synaptic transmission
- 2012 - 2012 Functional role of syntaxin 1B in the regulation of synaptic vesicle exocytosis and of the readily releasable pool at central synapses
- 2007 - 2010 Role of Syntaxin5 isoforms in neuronal cells under ER stress
- 2007 - 2009 Analysis of syntaxin 1 gene knockout mice as an animal model for autistic disorder
- 2007 - 2008 Brain protection through calcium buffering system in mitochondria
- 2005 - 2006 Pathophysiology of mitochondrial control for neuronal death and brain protection
- 2003 - 2004 Mitochondrial regulation of ishcemic neuronal death
- 2001 - 2002 Brain protection from the neuronal death induced by spreading depression
- シナプス可塑性に関わる開口放出機構
- Mechanisms for exocytosis relatal to synaptic plasticity
Show all
Papers (18)：
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Tatsuya Mishima, Kenta Komano, Marie Tabaru, Takefumi Kofuji, Ayako Saito, Yoshikazu Ugawa, Yasuo Terao. Repetitive pulsed-wave ultrasound stimulation suppresses neural activity by modulating ambient GABA levels via effects on astrocytes. Frontiers in cellular neuroscience. 2024. 18. 1361242-1361242
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Tatsuya Mishima, Tomonori Fujiwara, Takefumi Kofuji, Ayako Saito, Yasuo Terao, Kimio Akagawa. Syntaxin 1B regulates synaptic GABA release and extracellular GABA concentration, and is associated with temperature-dependent seizures. Journal of neurochemistry. 2021. 156. 5. 604-613
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Tomonori Fujiwara, Takefumi Kofuji, Tatsuya Mishima, Kimio Akagawa. Syntaxin 1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS. The European journal of neuroscience. 2017. 46. 12. 2867-2874
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Kei Suga, Ayako Saito, Tatsuya Mishima, Kimio Akagawa. Data for the effects of ER and Golgi stresses on the ER-Golgi SNARE Syntaxin5 expression and on the βAPP processing in cultured hippocampal neurons. Data in brief. 2015. 5. 114-23
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Kei Suga, Ayako Saito, Tatsuya Mishima, Kimio Akagawa. ER and Golgi stresses increase ER-Golgi SNARE Syntaxin5: Implications for organelle stress and βAPP processing. Neuroscience letters. 2015. 604. 30-5
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MISC (22)：
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三嶋竜弥. 神経系でのカルシウム Caスパイク,Naスパイク. Clinical Neuroscience. 2023. 41. 7
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K. Suga, A. Saito, T. Mishima, K. Akagawa. ER stress is associated with increased expression of ER-Golgi SNAREs and reduced Ab secretion in neuronal cells. JOURNAL OF NEUROCHEMISTRY. 2012. 123. 98-98
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T. Kofuji, T. Fujiwara, M. Sanada, T. Mishima, K. Akagawa. Glial cells from STX1B-KO mice were less effective on neuronal survival than WT. JOURNAL OF NEUROCHEMISTRY. 2012. 123. 92-92
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Tatsuya Mishima, Tomonori Fujiwara, Masumi Sanada, Takefumi Kofuji, Kimio Akagawa. A study on the neuronal phenotype of syntaxin1B knockout mice: Implication of differential role of syntaxin1A and syntaxin1B in synaptic transmission. NEUROSCIENCE RESEARCH. 2011. 71. E109-E109
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Takefumi Kofuji, Tomonori Fujiwara, Masumi Sanada, Tatsuya Mishima, Kimio Akagawa. Distinct roles of HPC-1/STX1A and STX1B in neuronal survival. NEUROSCIENCE RESEARCH. 2011. 71. E221-E221
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Lectures and oral presentations (2)：
-
In vitro experiment: astrocyte activation requisite for long-lasting suppression of neural activity
(ICCN 2024 (INTERNATIONAL CONGRESS OF CLINICAL NEUROPHYSIOLOGY) 2024)
-
超音波刺激による非侵襲的な神経機能調節法の開発
(第46回日本神経科学大会 2023)
Education (4)：
- - 1999 University of Tsukuba
- - 1999 University of Tsukuba Graduate School, Division of Bioresearch
- - 1994 University of Tsukuba
- - 1994 University of Tsukuba Second Cluster of College
Professional career (2)：
- Ph. D (University of Tsukuba)
- (BLANK) (University of Tsukuba)
Work history (3)：
- 2024/04 - 現在 Kyorin University Faculty of Medicine
- 2021/04 - 現在 Kyorin University Faculty of Medicine
- 2012 - Kyorin University Faculty of Medicine
Association Membership(s) (4)：
THE JAPAN NEUROSCIENCE SOCIETY
, 比較物理生化学会
, 動物学会
, 日本生理学会
