Kurokawa Kazuo

クロカワカズオ | Kurokawa Kazuo

Affiliation and department：
Job title：専任研究員

Research field (1)： Cell biology

Research theme for competitive and other funds (28)：

2023 - 2026 Construction of a unified model on membrane traffic around the Golgi
2020 - 2023 Elucidation of the molecular mechanism for accurately and efficiently retrograde cargo transport from the Golgi to the ER
2018 - 2023 Full elucidation of sorting mechanisms in and around the Golgi apparatus by super-resolution live imaging
2020 - 2022 The elucidation of the mechanism of cellular localization of driver gene products and its medical application
2019 - 2022 Elucidation of cancer proliferation mechanisms based on signal transduction from organelles different from normal cells

2017 - 2022 Analysis of GPI-anchored protein sorting zone at the ER exit site

2017 - 2022 Toward an integrative understanding of functional zones in organelles

2016 - 2019 Identification of intracellular activation sites of mutated tyrosine kinases in tumor cells and drug development based on the cellular localization

2016 - 2018 Basic research for development of the DDS system considering tissue and intracellular drug distribution

2013 - 2018 Understanding of Molecular Mechanisms of Membrane Traffic by Live Imaging and Its Extension to Plant Higher Systems

2015 - 2017 Investigation of the mechanism of gene transfer by sonoporation for fetus

2014 - 2017 The mechanism of functional sub-compartment formation in the endoplasmic reticulum by membrane structure

2008 - 2013 Molecular Mechanisms of Protein Sorting in Membrane Traffic and Roles in Higher Plants

2010 - 2012 Live imaging analysis for the relationship between morphology and function in the ER membrane

2008 - 2009 Spatio-temporal imaging of ER membrane proteinsp' dynamics and their interaction

2005 - 2009 Analysis on the spatio-temporal regulation of cellular oncogenesis

2008 - 2008 可視化による膜交通の選別分子機構の理解と植物の高次機能への展開

2008 - 2008 生きた酵母細胞内YptファミリーG蛋白質の時空間制御機構の解明

2006 - 2007 酵母細胞における低分子量G蛋白質の時間、空間的制御機構の解明

2005 - 2006 小胞輸送によるRhoファミリーG蛋白質の空間的制御機構

2004 - 2006 Spatiotemporal regulation of Rho-family GTPases

2004 - 2005 Multidimensional analysis of small GTPases as key molecules in the neural network formation by using activity-imaging

2004 - 2004 Imaging of Ras-MAP kinase signal transduction cascade

2003 - 2003 RhoファミリーG蛋白質群の時空間的制御と相互作用のFRETプローブによる解析

2002 - 2003 Rhoファミリ-GTP結合蛋白質の活性変化を生細胞で可視化する

1999 - 2003 低分子量G蛋白が細胞膜で情報を受け取るメカニズムの可視化

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Papers (55)：

Akihiro Harada, Masataka Kunii, Kazuo Kurokawa, Takuya Sumi, Satoshi Kanda, Yu Zhang, Satomi Nadanaka, Koichiro M. Hirosawa, Kazuaki Tokunaga, Takuro Tojima, et al. Dynamic movement of the Golgi unit and its glycosylation enzyme zones. Nature Communications. 2024. 15. 1
Takuro Tojima, Yasuyuki Suda, Natsuko Jin, Kazuo Kurokawa, Akihiko Nakano. Spatiotemporal dissection of the Golgi apparatus and the ER-Golgi intermediate compartment in budding yeast. eLife. 2024. 13
Yuuki Obata, Kazuo Kurokawa, Takuro Tojima, Miyuki Natsume, Isamu Shiina, Tsuyoshi Takahashi, Ryo Abe, Akihiko Nakano, Toshirou Nishida. Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in GIST cells. 2022
Yuriko Kakimoto-Takeda, Rieko Kojima, Hiroya Shiino, Manatsu Shinmyo, Kazuo Kurokawa, Akihiko Nakano, Toshiya Endo, Yasushi Tamura. Dissociation of ERMES clusters plays a key role in attenuating the endoplasmic reticulum stress. iScience. 2022. 25. 11. 105362-105362
Sofia Rodriguez-Gallardo, Susana Sabido-Bozo, Atsuko Ikeda, Misako Araki, Kouta Okazaki, Miyako Nakano, Auxiliadora Aguilera-Romero, Alejandro Cortes-Gomez, Sergio Lopez, Miho Waga, et al. Quality-controlled ceramide-based GPI-anchored protein sorting into selective ER exit sites. Cell reports. 2022. 39. 5. 110768-110768

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MISC (3)：

山名則和, 荒川芳輝, 西野共逹, 黒川量雄, 丹治正大, ジェームズ・モニペニー, 石崎敏理, 尾藤晴彦, 野崎和彦, 橋本信夫, et al. 細胞遊走・浸潤におけるRho/mDia1情報伝達系の制御. 日本癌学会総会記事. 2006. 65回. 456-456
Kazuo Kurokawa, Michiyuki Matsuda. Localized RhoA activation as a requirement for the induction of membrane ruffling. CELL STRUCTURE AND FUNCTION. 2005. 30. 61-61
K Kurokawa, M Matsuda. Spatio-temporal regulation of RhoA activity in living cells. MOLECULAR BIOLOGY OF THE CELL. 2004. 15. 289A-289A

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