AKIRA WATANABE

ワタナベアキラ | AKIRA WATANABE

Affiliation and department：

Research field (2)： Pathobiochemistry , Molecular biology

Research keywords (2)：分子腫瘍学 , 分子生物学

Research theme for competitive and other funds (24)：

2023 - 2026 Optimizing immunity in hematopoietic stem cell transplantation focusing on HLA epitopes
2021 - 2025 Development of tooth regenerative technology based on the spatiotemporal transcriptome analysis and iPS interference
2021 - 2024 点鼻タウワクチンによる脳内免疫応答の解明とナノ粒子のベクター利用
2020 - 2023 Clarification of the mechanism of mesenchymal stem cell stemness using iPS interference method
2020 - 2023 Identification of key factors for tooth development using spatial transcriptomics

2019 - 2023 非侵襲的ゲノム・エピゲノム解析による細胞の状態遷移の解明

2019 - 2022 The clarification of bone formation and absorption mechanism in the bone marrow microenvironment

2019 - 2022 Development of innovative technologies towered organ regeneration by control of organ fate

2018 - 2021 Understanding of molecular mechanisms of tooth development using iPS interference and application to tooth regeneration techniques

2018 - 2021 Selective differentiation of adult renal cell types from human iPS cells using single cell analyses of the differentiation mechanisms

2017 - 2021 Molecular understanding of the accumulation of mesenchymal stem cells in vivo by photo-manipulation techniques and its application to bone-related diseases

2018 - 2020 Elucidation of undifferentiated maintaining mechanism of stem cell towards the control of stem cell aging

2017 - 2020 Digitalization of transcription by single allele analysis

2016 - 2019 The development of bone regeneration therapy based on the clarification of mechanism of BMP-2 induced bone formation and resorption

2015 - 2019 Guided control of keratinized epithelial mucosa as a next generation periodontal soft tissue regeneration

2016 - 2018 Search of master regulator of odontoblastogenesis using iPS interference

2015 - 2018 Mechanism based development of differentiation method for pancreatic bud-like cells from human pluripotent stem cells

2015 - 2018 Dissecting Cell Fate Decision by Single Cell Genomics

2015 - 2018 Investigation of functional roles of mutant IDH as specific mutations in cartilage-forming tumors and its application for the development of treatment

2014 - 2017 Myotonic dystrophy type 1 patient-derived iPSCs for the investigation of CTG repeat instability

2013 - 2015 Molecular understanding of gliomagenesis using neural differentiation sysytem

2007 - 2011 Molecular mechanisms underlying nuclear reprogramming of somatic cells

2009 - 2010 Transcriptional network regulate d by a candidate tumor suppressor gene DA CH1

癌遺伝子・癌抑制遺伝子の機能解析

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Papers (128)：

Shin-Ichi Mae, Fumihiko Hattanda, Hiroyoshi Morita, Aya Nozaki, Naoko Katagiri, Hanako Ogawa, Kaori Teranaka, Yu Nishimura, Aoi Kudoh, Sanae Yamanaka, et al. Human iPSC-derived renal collecting duct organoid model cystogenesis in ADPKD. Cell Reports. 2023. 42. 12. 113431-113431
Atsushi Hatanaka, Sota Nakada, Gen Matsumoto, Katsuya Satoh, Iori Aketa, Akira Watanabe, Tomoaki Hirakawa, Tadayuki Tsujita, Tsuyoshi Waku, Akira Kobayashi. The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis. Scientific reports. 2023. 13. 1. 14405-14405
Tetsunori Sakamoto, Masahiko Ajiro, Akira Watanabe, Shingo Matsushima, Keiji Ueda, Masatoshi Hagiwara. Application of the CDK9 inhibitor FIT-039 for the treatment of KSHV-associated malignancy. BMC Cancer. 2023. 23. 1
Shunsuke Kawai, Junko Sunaga, Sanae Nagata, Megumi Nishio, Masayuki Fukuda, Takeshi Kamakura, Liping Sun, Yonghui Jin, Satoko Sakamoto, Akira Watanabe, et al. 3D osteogenic differentiation of human iPSCs reveals the role of TGFβ signal in the transition from progenitors to osteoblasts and osteoblasts to osteocytes. Scientific reports. 2023. 13. 1. 1094-1094
Tatsuki Ueda, Sara Shiina, Shoichi Iriguchi, Seitaro Terakura, Yohei Kawai, Ryotaro Kabai, Satoko Sakamoto, Akira Watanabe, Kohei Ohara, Bo Wang, et al. Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells. Nature biomedical engineering. 2023. 7. 1. 24-37

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MISC (41)：

Hisato Tatsuoka, Daisuke Yabe, Satoko Sakamoto, Akira Watanabe, Ryota Usui, Shinsuke Tokumoto, Ainur Botagarova, Daisuke Ootani, Hisanori Goto, Muhammad Fauzi, et al. Single Cell RNA-Sequencing Dissects Proliferation of Pancreatic Beta Cells. DIABETES. 2019. 68
龍岡久登, 矢部大介, 坂本智子, 渡辺亮, 徳本信介, ボタガロワ・アイヌラ, 臼井亮太, 後藤久典, ファウジ・ムハンマド, 小倉雅仁, et al. RNAシークエンスとATACシークエンスを用いた,加齢における膵β細胞増殖能低下のメカニズムの解析. 糖尿病. 2019. 62. Suppl.1. S-120
Kazuhisa Chonabayashi, Masahiro Kawahara, Akira Watanabe, Masahiro Nakamura, Masatoshi Nishizawa, Akifumi Takaori-Kondo, Shinya Yamanaka, Yoshinori Yoshida. Ips Technology Revealed the Genetic and Functional Diversity Present in a Secondary AML Patient. BLOOD. 2016. 128. 22
荒木啓充, 三浦史仁, 渡辺亮, 森永千佳子, 北岡文美代, 坂井徳子, 柴田由美子, 寺田基剛, 山中伸弥, 高橋政代, et al. 自家iPS細胞由来網膜色素上皮シートの一塩基解像度メチル化解析. 日本分子生物学会年会プログラム・要旨集(Web). 2016. 39th
Atsushi Hasegawa, Hiroshi Kaneko, Daishi Ishihara, Masahiro Nakamura, Akira Watanabe, Cecelia D. Trainor, Yamamoto Masayuki, Ritsuko Shimizu. GATA1 Changes DNA-Binding Fashion in a Binding-Site-Specific Manner and Alters Transcriptional Activity during Erythropoiesis. BLOOD. 2015. 126. 23

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Patents (2)：

抗ROBO1抗体を用いる癌の診断および治療
DKK1の遺伝子、蛋白質及び抗体を用いた癌の診断・モニター方法及び治療方法

Books (9)：

整形・災害外科「シングルセル解析の最前線」
金原出版 2018
シングルセル解析プロトコール「幹細胞・発生研究とシングルセル解析」
羊土社 2017
実験医学別冊エピジェネティクス解析スタンダード「エピゲノムデータベースの現状と活用」
羊土社 2017
月刊細胞「生物学の方法論を変えるシングルセル遺伝子発現解析」
ニューサイエンス社 2017
医学のあゆみ一細胞遺伝子発現解析「シングルセル発現解析による多能性幹細胞研究」
医歯薬出版社 2016

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Lectures and oral presentations (74)：

細胞治療時代に求められる次世代ゲノム・インテグリティ解析
(第17回再生医療学会 2018)
次世代シングルセル解析技術が支えるシステム生物学
(臨床ゲノムデータサイエンティスト養成講習会 2018)
細胞社会学を明らかにするシングルセルバイオオジー
(がんの病態解明から臨床応用における微量サンプル解析最前線 2018)
Cell Fate Analysis in Oncology Field
(別府がん若手研究者の勉強会 2017)
Single Cell Transcriptome Analysis Dissects Cell Fate Specification
(第12回国際ゲノム会議 2017)

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Professional career (1)：

工学博士 (東京大学)

Work history (2)：

The University of Tokyo Center for Collaborative Research
The University of Tokyo Research Center for Advanced Science and Technology

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