Nakano Michiyo

ナカノミチヨ | Nakano Michiyo

Affiliation and department：
Job title： Professor

Research field (1)： Community dentistry

Research theme for competitive and other funds (31)：

2023 - 2026 歯科・腎臓内科コラボレーション:口腔細菌によるIgA腎症発症メカニズムの追求
2023 - 2026 口腔バイオフィルム感染症制御法確立のための新規ターゲットタンパクの解析
2023 - 2026 S. mutans コラーゲン結合タンパクに着目した IgA 腎症発症機構の解明
2022 - 2025 S. mutans 口腔バイオフィルム形成における新たな分子シャペロンの機能解明
2021 - 2025 う蝕原性細菌のコラーゲン結合能に着目した低中所得国の全身疾患低減に向けた新戦略

2021 - 2024 口腔細菌叢のメタゲノム解析による非アルコール性脂肪肝炎発症機序解明と新規予防戦略

2021 - 2024 歯周病レッドコンプレックスとIgA腎症発症進展機序解明と新規治療法の開発

2021 - 2024 骨系統疾患患者の歯科病態の包括的検証と新規治療薬の歯科領域における評価

2021 - 2024 口腔内細菌叢の網羅的解析による口腔粘膜障害への臨床アプローチ

2020 - 2023 膜タンパクをターゲットとした新たな口腔バイオフィルム制御法の確立

2020 - 2023 歯科領域からの革新的治療法の開発を目指した口腔細菌に起因するIgA腎症の病態解明

2019 - 2022 Association of dental disease and kidney disease: Examination of oral specimens and renal biopsy / tonsil specimens of IgA nephropathy patients

2017 - 2020 Elucidation of the relationship between P. gulae infection and periodontitis onset mechanism

2017 - 2020 Dental caries prevention methods using GbpC glucan-binding domain in S. mutans.

2016 - 2019 ABC transporter function in biofilm formation and its application for dental caries prevention

2016 - 2018 Clinical and basic investigations for proposal regarding chemotherapy use in pediatric dentistry

2015 - 2018 Construction of global standard molecular epidemiological method for identification of the children at risk for severe dental caries

2015 - 2018 Basic and clinical approaches for dental problems associated with skeletal diseases

2015 - 2018 Clinical effects of hematopoietic stem cell transplantation on oral microflora using microbiological analysis

2015 - 2017 乳酸菌による新たな齲蝕発生メカニズムの解析

2013 - 2016 Establishment of evidence of effectiveness of amoxicillin in the subjects at risk for infective endocarditis

2013 - 2016 Relationship of Streptococcus mutans bacteriocin production with formation of biofilm

2013 - 2015 Mechanism of aggravation of periodontitis caused by periodontitis-related bacteria transmitted from companion animals

2013 - 2015 Development of substrate with recombinase A to prevent dental caries

2012 - 2015 Functional analyses of expression and regulation of glucan-binding protein B in Streptococcus mutans

2011 - 2014 Functional analysis of signal transduction system involving membrane transporters in Streptococcus mutans

2011 - 2013 Study on canine periodontal disease as zoonosis

2010 - 2012 Analysis of biological function of recombinase A in Streptococcus mutansquorum sensing

2008 - 2010 Analysis of mutans streptococci signal transduction system in biofilm formation

2006 - 2007 Molecular analysis of gloom-binding Protein in canes Pathogenesis of S. mutans

2003 - 2004 植物ポリフェノールのう蝕抑制効果に関する分子生物学的解明

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Papers (116)：

Jinthana Lapirattanakul, Ryota Nomura, Rena Okawa, Pornpen Tantivitayakul, Rattiporn Kaypetch, Anna Lehrkinder, Peter Lingström, Dowen Birkhed, Michiyo Matsumoto-Nakano, Kazuhiko Nakano. Multilocus sequence typing and phenotypic properties of Streptococcus mutans from Thai children with different caries statuses. BMC Oral Health. 2024. 24. 1
Masakazu Hamada, Kyoko Nishiyama, Ryota Nomura, Tatsuya Akitomo, Chieko Mitsuhata, Yoshiaki Yura, Kazuhiko Nakano, Michiyo Matsumoto-Nakano, Narikazu Uzawa, Hiroaki Inaba. Clinical relationships between the intratumoral microbiome and risk factors for head and neck cancer. Heliyon. 2024. 10. 20. e39284
Shuhei Naka, Daiki Matsuoka, Taro Misaki, Yasuyuki Nagasawa, Seigo Ito, Ryota Nomura, Kazuhiko Nakano, Michiyo Matsumoto-Nakano. Contribution of collagen-binding protein Cnm of Streptococcus mutans to induced IgA nephropathy-like nephritis in rats. Communications biology. 2024. 7. 1. 1141-1141
Sho Yoshida, Hiroaki Inaba, Ryota Nomura, Kazuhiko Nakano, Michiyo Matsumoto-Nakano. Role of fimbriae variations in Porphyromonas gulae biofilm formation. Journal of oral biosciences. 2024
Tatsuya Akitomo, Satoru Kusaka, Mariko Kametani, Chieko Mitsuhata, Shuhei Naka, Michiyo Matsumoto-Nakano, Kazuhiko Nakano, Ryota Nomura. High-performance silica-containing professional mechanical tooth-cleaning paste that effectively adsorbs pigments. Pediatric Dental Journal. 2024. 34. 2. 62-69

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MISC (242)：

宮井由記子, 仲周平, 仲野道代. 侵襲性歯周炎を疑う小児から得たActinomyces naeslundiiのバイオフィルム形成能の検討. 小児歯科学雑誌. 2024. 62
伊藤誓悟, 三崎太郎, 長澤康行, 松岡大貴, 仲周平, 野村良太, 仲野道代, 仲野和彦. う蝕原性細菌cnm陽性Streptococcus mutansは扁桃を介してIgA腎症を増悪させる. 日本腎臓学会誌(Web). 2024. 66. 4
仲周平, 吉田翔, 松三友紀, 稲葉裕朗, 仲野道代. 多嚢胞性脳軟化症患児口腔内における多数埋伏歯の1例. 小児歯科学雑誌. 2023. 61
後藤花奈, 仲周平, 仲野道代. 歯牙腫による下顎右側側切歯および犬歯の萌出不全を認めた1例. 小児歯科学雑誌. 2023. 61
臼田桃子, 亀谷茉莉子, 秋友達哉, 末廣雄登, 又吉紗綾, 中野将志, 光畑智恵子, 仲周平, 仲野道代, 仲野和彦, et al. ホタテ貝由来アパタイトのStreptococcus mutansに対する齲蝕予防効果の分析. 小児歯科学雑誌. 2023. 61

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Lectures and oral presentations (2)：

乳⻭の早期脱落が認められた小児と健常児の口腔細菌叢の比較
(第 42 回岡山⻭学会総会・学術集会 2021)
Porphyromonas gulae 線毛のバイオフィルム形成能と遺伝子多型の関連
(第 42 回岡山⻭学会総会・学術集会 2021)

Professional career (1)：

PhD (Osaka University)

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