Rchr
J-GLOBAL ID：200901013439684545
Update date: Jul. 19, 2024
NARIYA HIROFUMI
ナリヤ ヒロフミ | NARIYA HIROFUMI
Affiliation and department：
Job title：
教授
Research field (1)：
Applied microbiology
Research keywords (1)：
Pathogenic bacteria, Food poisoning bacteria, Clostridia, Clostridium perfringens, Signal transduction systems, Protein kinases and phosphatases, Cell-wall lytic enzymes, Endolysins
Research theme for competitive and other funds (13)：
- 2018 - 2021 Analysis of the regulatory mechanism of virulence expression by the retron containing reverse transcriptase gene in Vibrio cholerae
- 2018 - 2021 Research on Physiological and Molecular mechanism of Eukaryotic Protein Kinase - Phosphatase System that Regulates Morphology of Clostridium perfringens
- 2018 - 2021 ウエルシュ菌溶菌酵素の種特異性機構の解明と応用研究
- 2018 - 2020 ウエルシュ菌真核型プロテインキナーゼによる形態形成調節機構の解明
- 2015 - 2019 Research on factors regulating sporulation and enterotoxin production in Clostridium perfringens causing food-borne illness
- 2015 - 2018 Analysis of the species-specific molecular mechanism of C. perfringens-specific lytic enzyme Psm and its application
- 2013 - 2016 Study on Function of Eukaryotic Protein Kinase and Phosphatase in Firmicutes
- 2012 - 2015 Functional and pathogenic analysis of carbohydrate-active enzymes from Clostridium perfirngens
- 2009 - 2011 Study on Function of Eukaryotic Protein Kinase and Phosphatase in Firmicutes
- 2009 - 2011 A mechanism for regulation of clostripain activity and modification of inflammatory response by the enzyme.
- 2008 - 2010 Bent promoter of epsilon-toxin gene from Clostridium perfringens : analysis and application to protein expressions.
- 2006 - 2007 A study on a mechanism for the transcriptional regulation of an epsilon-toxin gene by a novel type of bent DNA
- 1997 - 1998 The mechanism of leukocytolysis and hemolysis of the Staphylococcal leukocidin and gamma-hemolysin
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Papers (94)：
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Riyo Aono, Shogo Emi, Kanako Okabe-Watanabe, Hirofumi Nariya, Nozomu Matsunaga, Yasuo Hitsumoto, Seiichi Katayama. Autolysin as a fibronectin receptor on the cell surface of Clostridium perfringens. Anaerobe. 2023. 83. 102769-102769
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Hiroshi Sekiya, Shigehiro Kamitori, Hirofumi Nariya, Risa Matsunami, Eiji Tamai. Structural and biochemical characterization of the Clostridium perfringens-specific Zn2+-dependent amidase endolysin, Psa, catalytic domain. Biochemical and biophysical research communications. 2021. 576. 66-72
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Eiji Tamai, Hiroshi Sekiya, Hirofumi Nariya, Seiichi Katayama, Shigehiro Kamitori. X-ray structures of Clostridium perfringens sortase C with C-terminal cell wall sorting motif of LPST demonstrate role of subsite for substrate-binding and structural variations of catalytic site. Biochemical and biophysical research communications. 2021. 554. 138-144
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Ahmed M Soliman, Hirofumi Nariya, Daiki Tanaka, Liansheng Yu, Junzo Hisatsune, Shizuo Kayama, Kohei Kondo, Motoyuki Sugai, Toshi Shimamoto, Tadashi Shimamoto. Vegetable-derived carbapenemase-producing high-risk Klebsiella pneumoniae ST15 and Acinetobacter baumannii ST2 clones in Japan: co-existence of blaNDM-1, blaOXA-66, blaOXA-72, and AbaR4-like resistance island from the same sample. Applied and environmental microbiology. 2021
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Hiroshi Sekiya, Maho Okada, Eiji Tamai, Toshi Shimamoto, Tadashi Shimamoto, Hirofumi Nariya. A Putative Amidase Endolysin Encoded by Clostridium perfringens St13 Exhibits Specific Lytic Activity and Synergizes with the Muramidase Endolysin Psm. Antibiotics (Basel, Switzerland). 2021. 10. 3
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MISC (9)：
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神鳥成弘, 玉井栄治, 玉井栄治, 関谷洋志, 成谷宏文, 片山誠一. ウェルシュ菌線毛タンパク質CppAとSortaseCのX線結晶構造解析. 日本生化学会大会(Web). 2019. 92nd
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神鳥成弘, 玉井栄治, 関谷洋志, 牧純, 成谷宏文. ウェルシュ菌線毛タンパク質CppAのX線結晶解析. 日本生化学会大会(Web). 2017. 90th
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神鳥成弘, 吉田裕美, 玉井栄治, 関谷洋志, 牧純, 成谷宏文. ウェルシュ菌Sortase BのX線結晶解析. 日本生化学会大会(Web). 2016. 89th
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片山 誠一, 加藤 早苗, 山先 歩武, 相谷 佳奈, 山崎 勤, 波多野 直哉, 成谷 宏文, 櫃本 泰雄. ウェルシュ菌の菌体表層にみられたフィブロネクチン結合蛋白質(FbpC、FbpD)の遺伝子同定と機能解析. 生物試料分析. 2015. 38. 1. 35-35
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加藤 早苗, 山崎 勤, 成谷 宏文, 櫃本 泰雄, 片山 誠一, 相谷 佳奈, 渡邊 真理子, 波多野 直哉. ウェルシュ菌の菌体表層にみられたフィブロネクチン結合タンパク質をコードする遺伝子の同定. 日本細菌学雑誌. 2014. 69. 1. 214-214
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Books (2)：
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Inouye S and Nariya H: Dual regulation with Ser/Thr kinase cascade and a His/Asp TCS in Myxococcus xanthus.In “Bacterial Signal Transduction: Networks and Drug Targets” (Edi.) Utsumi, Ryutaro, pp 111-121/242, Springer-Verlag, New York, 2008
2008
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Inouye S, Nariya H and Munoz-Dorado J: Protein Ser/Thr kinases and phosphatases in M. xanthus. Chapter 11 In “Myxobacteria: Multicellularity and Differentiation” (Edi.) Whitworth D, pp 191-210/552, ASM Press, Washington DC, 2007
2007
Lectures and oral presentations (46)：
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Biochemical and structural analysis of Clostridium perfringens Cell wall lytic enzyme CPE1138
(The 139th Annual Meeting of the Pharmaceutical Society of Japan (AMPSJ) 2019)
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A Novel Approach to Bio-control Food Poisoning Bacteria using Specific Phage-derived Endolysins
(The 6th Annual Meeting for Structural and Molecular Microbiology 2019)
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国産食肉より分離したカルバペネマーゼ(NDM-1, VIM-1)産生肺炎桿菌の解析
(日本食品衛生学会 第114回学術講演会 2018)
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qRT-PCR法を利用したウイルスゲノム測定による抗ノロウイルス剤の効果検定における注意点
(日本防菌防黴学会第45回年次大会 2018)
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Vibrio mimicusのレトロンの構造と機能解析
(第52回 ビブリオシンポジウム 2018)
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Education (1)：
- - 1997 Tohoku university Department of Applied Microbiology, Graduate School of Agricultural Science Bioscience, Biotechnology, and Agrochemistry, Ph.D.
Professional career (1)：
Work history (8)：
- 2020/04 - 現在 Jumonji University
- 2016/10 - 2020/03 Laboratory of Food Microbiology and Hygiene, Graduate School of Biosphere Science, Hiroshima University Associate Professor
- 2007/02/16 - 2016/09/30 Department of Microbiology, Faculty of Medicine, Kagawa University Assistant Professor
- 2006/05 - 2007/01 Department of Biochemistry, UMDNJ-RWJMS, USA Adjunct Assistant Professor
- 2001/04 - 2006/05 Department of Biochemistry, UMDNJ-RWJMS, USA Research Teaching Specialist III
- 1998/05 - 2001/04 Department of Biochemistry, University of Medicine and Dentistry of New Jersey (UMDNJ)-Robert Wood Johnson Medical School (RWJMS), USA Postdoctoral Fellow
- 1997/04 - 1998/03 Department of Applied Microbiology, Graduate School of Agricultural Science, Tohoku University Research Fellow of the Japan Society for the Promotion of Science (PD)
- 1996/04 - 1997/03 Department of Applied Microbiology, Graduate School of Agricultural Science, Tohoku University Research Fellow of the Japan Society for the Promotion of Science (DC)
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Awards (3)：
- 2018/03/28 - The 91st Annual Meeting of Japanese Society for Bacteriology, Best Presentation Award Biocontrol of Clostridium perfringens by using two types of specific endolysins
- 2017/03/20 - The 90th Annual Meeting of Japanese Society for Bacteriology, Best Presentation Award Development of novel expression system using codonmodified T7 RNAP and Xyl-uptake system for clostridial gene
- 1998/04/01 - JSBBA, Award for Young Scientists 1998 Study on the two Staphylococcal bi-component toxins, leukocidin and gamma-hemolysin
Association Membership(s) (1)：
The Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA), Japanese Society for Bacteriology (JSB), The American Society For Microbiology (ASM)
