Ueyama Takehiko

ウエヤマタケヒコ | Ueyama Takehiko

Affiliation and department：
Job title： Associate Professor

Research field (3)： Medical biochemistry , Neuroscience - general , Pharmacology

Research keywords (4)： 1103 , 6905 , 6904 , 5805

Research theme for competitive and other funds (25)：

2024 - 2027 活性酸素産生酵素NOX3の発現制御機序解明による後天性及び片側性難聴の治療法開発
2021 - 2024 脊髄小脳変性症でのPKCリン酸化を介した神経保護機構の解明と新規治療法への応用
2021 - 2024 Acquired sensorineural hearing loss caused from Nox3-derived ROS
2019 - 2022 Challenge for establishing the criteria of laterality-based diseases in hearing and vision
2018 - 2021 Investigation for gene transfer therapy in inner ears

2018 - 2021 Development of a novel treatment for Parkinson's disease focusing on the protective effect of CSPa phosphorylation on synaptic terminal

2017 - 2020 Elucidation of amyloid formation mechanism in Spinocerebellar ataxia and its application to drug therapy

2017 - 2020 Mechanism clarification of new symptoms in DFNA1 causing from constitutively active DAI1 mutants

2014 - 2017 Roles of Rho-family small GTPases in establishment and maintenance for hearing and balancing

2014 - 2016 Elucidation of a new differentiation mechanism of beige adipocytes and its application for drug design

2013 - 2016 Determination of PKC substrate involved in neurodegenerative diseases and its application for drug design

2011 - 2012 Roles of p40phox in Crohn disease and its application for drug development

2010 - 2012 Roles of small GTPases and ROS in functions anddiseases of inner ear

2012 - 二国間交流「活性酸素種(ROS)特異的プローブの開発とDuoxによるROSメカニズムの解明」

2010 - 2011 Production and analysis of model animals for neurodegenerative diseases caused by dysfunction of PKC and their use for drug design

2011 - 二国間交流「活性酸素種(ROS)特異的プローブの開発とDuoxによるROSメカニズムの解明」

2008 - 2009 貪食細胞における活性酸素産生トランスポートソームの形成・活性化機構の解明

2007 - 2008 Analysis of activation mechanism of new members of NADPH oxidase family

2007 - 2008 Mechanism and treatment for the disease caused by the impairment of PKC signaling

2006 - 2007 性ホルモンの神経保護作用におけるグリア・ニューロン内情報伝達クロストーク機構

2005 - 2006 非貪食細胞の最終分化による活性酸素産生能の獲得とその制御機構の解明

2005 - 2006 Molecular mechanism of cellular response induced by dynamic metabolism of membrane phospholipid

2005 - 2005 活性酸素産生機構における脂質シグナルのダイナミックイメージング解析

2005 - 核内脂質シグナル及び核移行蛋白質の可視化システムを用いた細胞周期制御機構の解明

2003 - 2004 ファゴサイトーシス時に働くシグナルカスケードのリアルタイム解析

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Papers (66)：

Takashi Sasayama, Takeshi Hamada, Kazuhiro Tanaka, Hiroaki Nagashima, Shunsuke Yamanishi, Takehiko Ueyama. Potential of GSPT1 as a novel target for glioblastoma therapy. Cell Death & Disease. 2024. 15. 8
Takeshi Kaizuka, Takehiro Suzuki, Noriyuki Kishi, Kota Tamada, Manfred W. Kilimann, Takehiko Ueyama, Masahiko Watanabe, Tomomi Shimogori, Hideyuki Okano, Naoshi Dohmae, et al. Remodeling of the postsynaptic proteome in male mice and marmosets during synapse development. Nature Communications. 2024. 15. 1
Shunkou Kurasawa, Hiroaki Mohri, Keiji Tabuchi, Takehiko Ueyama. Loss of synaptic ribbons is an early cause in ROS-induced acquired sensorineural hearing loss. Neurobiology of disease. 2023. 186. 106280-106280
Takashi Nakamura, Hirofumi Sakaguchi, Hiroaki Mohri, Yuzuru Ninoyu, Akihiro Goto, Taro Yamaguchi, Yoshitaka Hishikawa, Michiyuki Matsuda, Naoaki Saito, Takehiko Ueyama. Dispensable role of Rac1 and Rac3 after cochlear hair cell specification. Journal of Molecular Medicine. 2023. 101. 843-854
Yoko Niki, Naoko Adachi, Masaki Fukata, Yuko Fukata, Shinichiro Oku, Chieko Makino-Okamura, Seiji Takeuchi, Kazumasa Wakamatsu, Shosuke Ito, Lieve Declercq, et al. S-Palmitoylation of Tyrosinase at Cysteine500 Regulates Melanogenesis. The Journal of investigative dermatology. 2022. 143. 2. 317-327

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MISC (2)：

坂口博史, 中村高志, 上山健彦. めまい疾患のモデル動物-遺伝子医療・再生医療への扉聴覚・平衡覚の成立におけるRho-GTPaseの関与. Equilibrium Research. 2017. 76. 6. 720-726
中村高志, 坂口博史, 森岡繁文, 久育男, 上山健彦, 齋藤尚亮. Cdc42による蝸牛有毛細胞不動毛の形態維持. 耳鼻咽喉科ニューロサイエンス. 2015. 29. 24-26

Lectures and oral presentations (28)：

NOX由来ROSによる後天性感音難聴の発症機序(標的)と治療法開発戦略
(第96回日本生化学会大会シンポジウム 2023)
アクチン細胞骨格異常が関与する感音難聴の発症機序~Rho-family small GTPasesに注目
(第96回日本生化学会大会シンポジウム 2023)
Acquired hearing loss induced by ROS and challenges for therapy development based on its mechanism
(2022)
遺伝子改変マウスからの疾患病態解明と治療法開発戦略へのフィードバック
(第60回日本組織細胞化学会総会シンポジウム 2019)
Strategy based on knowledge obtained from patients and mice models for development of novel therapy against hereditary sensorineural hearing loss (HSNHL) causing from impaired actin turnover
(2019)

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Education (1)：

Professional career (1)：

Committee career (2)：

Awards (1)：

2005/08 - 広島大学医学部医学科広仁会広島大学医学部医学科広仁会「平成17年度基礎医学研究賞」新規NADPH oxidase (Nox4) の活性化機構と神経膠腫浸潤における役割の解明

Association Membership(s) (5)：

米国免疫学会 , 日本生化学会 , 日本薬理学会 , 北米神経科学会 , 日本脳神経外科学会

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