Rchr
J-GLOBAL ID：200901014318437784   Update date: Mar. 19, 2024

Nagasawa Takashi

ナガサワ タカシ | Nagasawa Takashi
Affiliation and department：
Osaka University Institute for Frontier Medical SciencesField of Medical Systems Engineering Department of Medical Systems Control

About Osaka University Institute for Frontier Medical SciencesField of Medical Systems Engineering Department of Medical Systems Control


Job title： Professor
Homepage URL  (1)： http://www.fbs.osaka-u.ac.jp/jpn/general/lab/132/
Research field  (3)： Immunology ,  Developmental biology ,  Hematology and oncology
Research keywords  (11)： microenvironment ,  hematopoietic stem cell ,  niche ,  ケモカイン ,  サイトカイン ,  造血 ,  免疫学 ,  Chemokine ,  Cytokine ,  Hematopoiesis ,  immunology
Research theme for competitive and other funds  (33)：
  • 2022 - 2026 免疫系を維持、調節する微小環境(ニッチ)の形成と機能の分子機構の解明
  • 2018 - 2022 Molecular mechanisms underlining regulation of HSC niche formation and maintenance
  • 2017 - 2019 造血幹細胞ニッチを構成する骨髄間葉系前駆細胞の老化とその分子機構の解明
  • 2016 - 2019 Analysis of immune microenvironment essential for ILC2 development
  • 2012 - 2017 Molecular mechanisms by which microenvironmental niches regulate production of immune cells.
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Papers (90)：
  • Yoshiki Omatsu, Shota Aiba, Tomonori Maeta, Kei Higaki, Kazunari Aoki, Hitomi Watanabe, Gen Kondoh, Riko Nishimura, Shu Takeda, Ung-il Chung, et al. Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells. Nature Communications. 2022. 13. 1
  • 倉重 真沙子, 杉山 立樹, 大島 健司, 田原 紳一郎, 松井 崇浩, 藤野 雅彦, 伊藤 雅文, 長澤 丘司, 森井 英一. MPN関連骨髄線維症においてCAR細胞より分化した線維芽細胞は造血幹細胞移植後早期にCXCL12産生能を回復する. 日本病理学会会誌. 2022. 111. 1. 251-251
  • Isringhausen S, Mun Y, Kovtonyuk L, Kräutler NJ, Suessbier U, Gomariz A, Spaltro G, Helbling PM, Wong HC, Nagasawa T, et al. Chronic viral infections persistently alter marrow stroma and impair hematopoietic stem cell fitness. 2021. 218. e20192070
  • Nakagawa T, Jörg DJ, Watanabe H, Mizuno S, Han S, Ikeda T, Omatsu Y, Nishimura K, Fujita M, Takahashi S, et al. A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis. Cell Reports. 2021. 37. 3. 109875-109875
  • Takao Sudo, Yasutaka Motomura, Daisuke Okuzaki, Tetsuo Hasegawa, Takafumi Yokota, Junichi Kikuta, Tomoka Ao, Hiroki Mizuno, Takahiro Matsui, Daisuke Motooka, et al. Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions. Journal of Experimental Medicine. 2021. 218. 5
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MISC (26)：
  • 倉重真沙子, 杉山立樹, 大島健司, 田原紳一郎, 松井崇浩, 藤野雅彦, 伊藤雅文, 伊藤雅文, 長澤丘司, 森井英一. CAR cell-derived fibroblasts regain CXCL12 production early after HSCT in MPN-related myelofibrosis. 日本病理学会会誌. 2022. 111. 1
  • Yoshiki Omatsu, Yoshiki Omatsu, Takashi Nagasawa. Identification of microenvironmental niches for hematopoietic stem cells and lymphoid progenitors-bone marrow fibroblastic reticular cells with salient features. International Immunology. 2021. 33. 12. 821-826
  • Yoshiki Omatsu, Yoshiki Omatsu, Kei Higaki, Takashi Nagasawa. Cellular Niches for Hematopoietic Stem Cells and Lympho-Hematopoiesis in Bone Marrow During Homeostasis and Blood Cancers. Current Topics in Microbiology and Immunology. 2021. 33-54
  • 倉重 真沙子, 伊藤 雅文, 長澤 丘司, 森井 英一. 骨髄の病理とゲノム異常 造血幹細胞移植における骨髄再構築過程の病理 骨髄微小環境に着目して. 日本病理学会会誌. 2020. 109. 1. 211-211
  • Keisuke Omori, Nanae Nagata, Kaori Kurata, Yoko Fukushima, Erika Sekihachi, Nobutaka Fujii, Tomoko Namba-Hamano, Yoshitsugu Takabatake, Marcus Fruttiger, Takashi Nagasawa, et al. Inhibition of stromal cell-derived factor-1α/CXCR4 signaling restores the blood-retina barrier in pericyte-deficient mouse retinas. JCI insight. 2018. 3. 23
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Lectures and oral presentations  (8)：
  • “Adipo-osteogenic progenitors function as niches for hematopoietic stem and progenitor cells in the \nmarrow”
    (The 9th Nikko International Symposium 2012,(2012.10.12.Tochigi) 2012)
  • Bone inflammation, “Bone marrow niches for hematopoietic \nstem and progenitor cells”
    (第32回 日本炎症・再生医学会、シンポジウム(2011/06/03 国立京都国際会館 京都) 2011)
  • “Adipo-osteogenic progenitors constitute reticular niches for hematopoietic stem \nand progenitor cells”
    (The 23th Korean Sciety of Bone Metabolism Autumn Scientific Congress, Satellite Symposium:Bone and Hematopoietic System.November 19, 2011, Seoul, Korea 2011)
  • The chemokine CXCL \n12 and niches for hematopoietic stem cells and immune cells”
    (14th International Congress of Immunology. Symposium : cellular trafficking.(August 24 (23-27), 2010, Kobe, Japan) 2010)
  • “The chemokine CXCL12 and bone marrow \nniches for hematopoietic stem cells (HSCs) and immune cells.”
    (3rd International Conference on Osteoimmunology.(June 21-25, 2010, Fira, Santorini, Greece) 2010)
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Education (2)：
  • - 1993 Osaka University
  • - 1987 Nagoya University School of Medicine
Professional career (1)：
  • 医学博士 (大阪大学)
Work history (3)：
  • 2016 - 現在 Osaka University Graduate School of Frontier Biosciences
  • 2002 - 2015 Kyoto University Institute for Frontier Medical Sciences
  • 1995 - 2002 Osaka Women's and Children's Hospital Research Institute
Awards (3)：
  • 2019 - The Japan Academy Japan Academy Prize
  • 2014 - Takeda Prize for Medical Science
  • 1998/12 - The Japanese Society for Immunology Prize
Association Membership(s) (2)：
日本免疫学会 ,  日本骨免疫学会
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