Kawahara Kazuyoshi

カワハラカズヨシ | Kawahara Kazuyoshi

Homepage URL (1)： http://kougaku.kanto-gakuin.ac.jp/modules/course43/index.php?id=1&tmid=63

Research field (3)： Bacteriology , Applied microbiology , Biochemistry

Research keywords (6)：環境微生物学 , 糖脂質生化学 , 応用微生物学 , Environmental microbiology , Glycolipid biochemistry , Applied microbiology

Research theme for competitive and other funds (13)：

2012 - 2015 乳酸菌糖脂質およびペプチドグリカンの自然免疫活性化における役割
2011 - 2014 酵素を利用したサリン等の神経剤分解法の開発と汚染除去法に関する研究
2006 - 2009 生物化学テロにおける効果的な除染法の開発
2002 - 2005 ペスト菌エンドトキシンの化学構造および感染における役割
1999 - 2002 生物学的ダイオキシン分解技術の開発研究

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Papers (95)：

Kazuyoshi Kawahara. Variation, modification and engineering of lipid a in endotoxin of gram-negative bacteria. International Journal of Molecular Sciences. 2021. 22. 5. 1-15
Kazuyoshi Kawahara, Hirokazu Iida, Akira Yokota. Detection of 2-hydroxy-fatty acids and 2-hydroxy-fatty acid-containing ceramides in a gliding marine bacterium aureispira marina. Journal of General and Applied Microbiology. 2021. 67. 3. 100-105
Chiho Taniguchi, Takehiro Sugawara, Sakura Onoue, Kazuyoshi Kawahara. Structural modification of Escherichia coli lipid A by myristoyltransferase gene from Klebsiella pneumoniae. Microbiology and Immunology. 2019
Kazuyoshi Kawahara. Synthetic chemistry with friendships that unveiled the long-lasting mystery of lipid A. Innate Immunity. 2019. 25. 3. 203-212
Takehiro Sugawara, Sakura Onoue, Hiroaki Takimoto, Kazuyoshi Kawahara. Modification of lipid A structure and activity by the introduction of palmitoyltransferase gene to the acyltransferase-knockout mutant of Escherichia coli. Microbiology and Immunology. 2018. 62. 8. 497-506

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MISC (19)：

Kazuyoshi Kawahara, Sho Noguchi, Sakura Onoue. Preparation of peptidoglycan from Lactobacillus fermentum and abalysis of amino acids contained in it using GC-MS. Journal of Technological Researches (Kanto Gakuin University). 2020. 63. 1-4
K. Kawahara, M. Ito. Analysis of lipid A structure in &It;DB>Escherichia coli(/)-&It;/DB> mutant strains by MALDI-TOF Mass Spectrometry. "jointly worked". The Journal of Technological Researches. The College of Engineering. Kanto Gakuin University. 2012. 55. 2. 125-132
K. Kawahara, J. Yamashita, M. Asai, T. Nozawa, N. Saro. Chemical structure of the glycosphingolipid isolated from &It;DB>Sphingomonas trueperi(/)-&It;/DB>. The Journal of Technological Researches. The College of Engineering. Kanto Gakuin University. 2007. 50. 2. 129-136
Teruo Itoi, Mieko Kataoka, Yasuo Seto, Kazuyoshi Kawahara, Junichi Iijima. on-site method for detectinf bacteria using flow cytometer. Japanese journal of science and technology for identification. 2004. 9. 1. 9-18
K. Kawahara, H. Takimoto, Y. Kumazawa, Y. Kawai. Glycosphingolipids from Sphingomonas(/)- and related bacteria: their structure and potency as immunomodulators "jointly worked". Proceedingd of The 2nd Chanwon International Symposium on Advanced Science and Technology. 2003. 101-105

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Patents (7)：

NKT細胞活性化用組成物、IL-4産生促進用組成物及びIFN-γ産生促進用組成物、出願人:(株)紀文フードケミファ、熊沢義雄、発明者:熊沢義雄、村田克巳、川原一芳、滝本博明
分解方法、浄化方法および分解菌、出願人:オルガノ(株)、(社)北里研究所、平石明、発明者:江口正浩、長谷部吉昭、川原一芳、平石明
Glycosphingolipids (USA, Canada, EU)
スフィンゴ糖脂質
スフィンゴ糖脂質、出願人:(株)紀文フードケミファ、(社)北里研究所発明者:川原一芳、村田克巳

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Books (22)：

Endotoxin and Innate Immunity 22
2019
Endotoxin and Innate Immunity 22
2019
Endotoxin and Innate Immunity 21
2018
Lipid A in cancer therapy (Ed: J.-F. Jeannin)
Landes Bioscience/Springer 2009
基礎病原微生物学(編集: 檀原宏文、田口文章)
廣川書店 2005

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Lectures and oral presentations (7)：

Modification of lipid A structure and immunological activity by the introduction of foreign fatty acid transferase genes
(15th International Congress of Bacteriology and Applied Microbiology, IUMS 2017 2017)
Construction of a mutant strain of Escherichia coli with lipid A lacking non-polar fatty acids and creation of novel acyloxyacyl structures in lipid A
(International Endotoxin and Innate Immunity Society 14th Biennial Meeting 2016)
Improvement of activity and immobilization of organophosphorus hydrolase for the decontamination of nerve agents
(International Union of Microbiological Societies Congress: XIVth International Congress of Bacteriology and Applied Microbiology 2014)
Chemical characterization of the carbohydrate portion of LPS from a marine isolate of Pseudomonas aeruginosa
(The 12th Biennial International Endotoxin & Innate Immunity Society Meeting 2012)
Decomposition of nerve agents by organophosphorus hydrolase
(The 50th Annual Meeting of the International Association of Forensic Toxicologists 2012)

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Works (6)：

有用スフィンゴ糖脂質の探索とその工業生産に関する基礎研究(紀文フードケミファ委託研究)
川原一芳 2004 - 2007
Study on <i>Yersinia pestis</i> lipopolysaccharide
2002 - 2004
Study on biological degradation of dioxins
1999 - 2002
スフィンゴ糖脂質生産菌及び利用に関する研究(紀文フードケミファ共同開発研究)
川原一芳 1998 - 2001
Study on bacterial glycosphingolipids
1998 - 2001

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Education (2)：

1977 - 1982 Graduate School, The University of Tokyo Graduate School, Division of Agricultural Science Agricultural Chemistry
1973 - 1977 The University of Tokyo Faculty of Agriculture Department of Agricultural Chemistry

Professional career (1)：

Doctor of Agriculture (The University of Tokyo)

Work history (4)：

2013/04 - 現在 Kanto Gakuin University College of Science and Rngineering Professor
2004/04 - 2013/03 Kanto Gakuin University College of Engineering Professor
1986/07 - 2004/03 The Kitasato Institute Researcher
1984/02 - 1986/06 Research Institute Borstel Division of Immunochemistry Guest Researcher

Committee career (7)：

2015/09 - 現在日本獣医学会評議委員
2015/01 - 現在日本エンドトキシン・自然免疫研究会理事
2015/01 - 現在日本細菌学会理事、評議員
2010 - 現在内毒素・LPS研究会事務局
2010 - 現在日本エンドトキシン・自然免疫研究会代議員

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Association Membership(s) (16)：

日本エンドトキシン研究会 , 日本糖質学会 , 日本獣医学会 , 日本生化学会 , 国際内毒素学会(International Endotoxin Society) , 日本細菌学会 , 日本農芸化学会 , Japan Endotoxin Society , The Japanese Society of Carbohydrate Research , The Japanese Society of Veterinary Science , The Japanese Biochemical Society , and Agrochemistry , Biotechnology , Japan Society for Bioscience , Japanese Society for Bacteriology , International Endotoxin Society

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