Rchr

J-GLOBAL ID：200901015160261469 Update date: Oct. 01, 2024

Tanaka Yoshimasa

タナカヨシマサ | Tanaka Yoshimasa

Affiliation and department：
Job title：教授
Homepage URL (1)： http://www.numic.nagasaki-u.ac.jp/

Research field (1)： Immunology

Research keywords (6)： Immunology , Gamma delta T cell , IL-18 , PD-1 immune checkpoint , NK cell , Nanobody

Research theme for competitive and other funds (57)：

2023 - 2027 プラスチックの吸入による肺や全身への健康影響
2022 - 2027 Support and development of mid-sized molecule drugs harnessing a marine microbial extract library
2023 - 2026 Elucidation of the mechanism of pneumonia exacerbated by Prevotella species and the development of brand-new treatments
2023 - 2026 Development of a new treatment strategy for pulmonary aspergillosis by innate immune effector cells
2023 - 2026 ヒトにおけるPD-1免疫チェックポイント阻害剤併用療法の作用機序解析

2023 - 2026 ライソゾーム栄養感知機構を標的としたNASH肝がん抑止を目指した創薬研究

2022 - 2025 ワクチン開発のための世界トップレベル研究開発拠点群⻑崎シナジーキャンパス(出島特区)

2022 - 2025 家族性地中海熱の病態における免疫老化の意義を明らかにする研究

2022 - 2025 Supply of drug library, drug optimization and a nonclinical trial of immunotherapy

2020 - 2024 細胞壁構成全成分の分子特性に関する統合的研究 -バイオマスの高機能化のために-

2020 - 2023 HSP47をターゲットとした肺線維症治療薬の開発

2020 - 2023 肺線維症におけるγδ細胞の役割解明と治療応用に向けた基盤研究

2022 - 2023 Development of a method for culturing immune effector cells harnessing highly active human interleukin-18 mutants

2019 - 2022 Elucidation and Overcoming Multidrug Resistance Mechanisms in the Pathogenic Fungus Candida

2019 - 2022 Development of biomarkers for "early diagnosis" and "realization of precision medicine" of familial Mediterranean fever

2020 - 2022 Development of a platform for next generation antibody therapeutics

2017 - 2022 実用化に向けたB型肝炎新規治療薬の探索及び最適化

2017 - 2022 実践創薬ナレッジとイノベーションで拓くリード創出

2020 - 2021 COVID-19に対するワクチンの開発

2017 - 2020 家族性地中海熱(FMF)インフラマソームシグナル伝達異常をゲノム創薬で解決する開発研究

2017 - 2020 薬剤耐性RNAウイルス出現予測法の確立と迅速制御のためのインシリコ創薬

2016 - 2019 Development of cell preparations and high/low molecular-weight therapeutics that exhibit synergistic effects with PD-1 immune checkpoint antibodies

2015 - 2019 Development of biomedical materials based on limited-degradation, separation, and reconjugation of biomass

2017 - 2018 IL-18誘導体による新規がん免疫療法の開発

2015 - 2018 多発性硬化症における革新的な医薬品等の開発を促進させる研究

2014 - 2017 Reproduction of chronic pain model through a reconstitution of neuronal circuit components including LPA priming and iPS cells, and its application for drug discovery

2013 - 2016 Innate immunity regulation by prothymosin alpha -mimetics

2015 - 2016 新規第四世代ビスホスホン酸を用いた抗腫瘍免疫治療法の開発

2011 - 2016 次世代免疫制御を目指す創薬医学融合拠点

2012 - 2015 Development and new functions of biomass hybrid materials with supramolecular structures

2012 - 2015 Analyses of interaction between IL-18-induced helper NK cells and cytotoxic gamma delta T cells

2011 - 2014 非ペプチド性低分子化合物を用いた低侵襲性がん免疫療法の確立

2009 - 2014 γδ型T細胞を標的とした癌免疫療法の開発

2009 - 2011 Precise synthesis of cellulosicblock copolymers with novel functions based on the irsupramolecular structure

2008 - 2010 Structural analysis of costimulatory molecules expressed on human γδ T cells

2004 - 2009 結核菌抗原類縁体を利用した癌標的免疫療法の確立 -γδ型T細胞の示す抗腫瘍作用の臨床応用-

2008 - 2009 PD-1/PD-L1系のシグナル遮断による新規がん免疫療法の開発

2007 - 2008 MicroRNA profiling of human lupus nephritis and murine lupus-like nephritis.

2006 - 2007 Identification of tumor antigens by the use of human γδ TCR tetramers

2004 - 2006 免疫細胞の非ペプチド性抗原認識機構における構造・機能相関解析

2005 - 2006 Study on the second immune response by using SPA-1-deficient mice.

2003 - 2006 Regulation and Control of Immune Surveillance

2001 - 2005 感染及び抗腫瘍免疫における交差性生体制御の意義

2004 - 2005 Analysis of mechanism for nonpeptide antigen recognition by structural determination of mutated human γδ T cell receptor

2004 - 2004 窒素含有型ビスホスホン酸によるがん標識免疫療法の基盤解析

2003 - 2004 A new model mice for human chronic myelogenous leukemia by the disruption of SPA-1 gene.

2003 - 2003 PD-1/PD-L1システム遮断と非ペプチド性抗原を用いた新規抗腫瘍免疫療法の開発

2002 - 2003 変異型γδ型TCRのX線結晶解析構造と抗原認識能との相関解析

2001 - 2002 非ペプチド性抗原を用いた新規がん免疫療法の開発

2001 - 2002 Mechanism for autoimmune dilated cardiomyopathy in PD-1-deficient mice

2001 - 2001 ピロリン酸モノエステル類縁体を用いた新規がん標的治療法の開発

2000 - 2001 Pattern recognition by human γδ T cells and innate immunity.

2000 - 2000 ヒトγδ型T細胞を用いた特異的癌免疫療法の開発

1998 - 2000 Studies on differentiation, maturation and activation of human T cells

1997 - 1999 Role of a new T cell marker, H4, on the differentiation and selection of T cells in the thymus

1997 - 1998 ヒトγδT細胞の認識する細菌性ピロリン酸系抗原の改変とその認識機構の解析

1996 - 1996 ヒトγδT細胞による非ペプチド抗原の認識機構

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Papers (158)：

Naoki Iwanaga, Ayaka Ota, Hiroki Ashizawa, Yuya Ito, Tatsuro Hirayama, Masataka Yoshida, Kazuaki Takeda, Shotaro Ide, Masato Tashiro, Naoki Hosogaya, et al. Clarithromycin Modulates Neutrophilic Inflammation Induced by Prevotella intermedia in Human Airway Epithelial Cells. Antibiotics (Basel, Switzerland). 2024. 13. 9
Wen Li, Denan Jin, Shinji Takai, Natsuko Inoue, Kyosuke Yamanishi, Yoshimasa Tanaka, Haruki Okamura. IL-18 primes T cells with an antigen-inexperienced memory phenotype for proliferation and differentiation into effector cells through Notch signaling. Journal of Leukocyte Biology. 2024
Hideki Hayashi, Tak Wah Mak, Yoshimasa Tanaka, Yoshinao Kubo, Mai Izumida, Ryuji Urae, Toshifumi Matsuyama. Development of a highly sensitive platform for protein-protein interaction detection and regulation of T cell function. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 33. e2318190121
Inthuon Kulma, Kesara Na-Bangchang, Andrea Carvallo Herrera, Ifeanyi Theodora Ndubuisi, Masashi Iwasaki, Hiromi Tomono, Craig T Morita, Haruki Okamura, Hiroshi Mukae, Yoshimasa Tanaka. Analysis of the Effector Functions of Vδ2 γδ T Cells and NK Cells against Cholangiocarcinoma Cells. Cells. 2024. 13. 16
Yoshimasa Tanaka. IL-4 within the bone marrow: a key driver of lung tumorigenesis. Journal of Leukocyte Biology. 2024

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MISC (106)：

宮下律子, 城戸貴志, 坂本憲穂, 城戸久美子, 野口康子, 小笹睦, 時任高諄, 奥野大輔, 由良博一, 石本裕士, et al. BEAT PCD TEM Criteriaの有用性の検証. 日本呼吸器学会誌. 2024. 13. 増刊. 244-244
Design principles of lipid nanoparticles. PHARM STAGE. 2023. 23. 6. 9-13
芦澤博貴, 岩永直樹, 伊藤裕也, 芦澤信之, 芦澤信之, 武田和明, 高園貴弘, 高園貴弘, 内藤真理子, 田中義正, et al. Prevotella intermediaがStreptococcus spp.による肺炎を増悪させる機序の探索. 日本嫌気性菌感染症学会雑誌. 2023. 53. 1
Yoshimasa Tanaka, Susumu Tanimura, Nao Yamaguchi, Ryuichi Kuroiwa, Kohsuke Takeda. Nanobody. 2022. 77. 6. 724-730
千住博明, 迎寛, 田中義正. γδT細胞による腫瘍制御. 炎症と免疫. 2022. 30. 3. 215-219

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Patents (14)：

新規ビスホスホン酸誘導体及びその用途
抗ウィルス薬
非RI系における細胞傷害能迅速測定法
新規オートファジー阻害剤としてのAtg4B阻害剤
免疫チェックポイント阻害剤の効果予測方法

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Lectures and oral presentations (178)：

BEAT PCD TEM Criteriaの有用性の検証
(日本呼吸器学会誌 2024)
Evaluation of the anti-fungal activity of ex-vivo-expanded human Vγ9Vδ2 T cells against Aspergillus species
(IDWeek2023 2023)
Early memory T細胞を標的とした肝細胞がんに対する新規治療法の開発
(第82回日本癌学会学術総会 2023)
γδT細胞にαβTCRを遺伝子導入するとミトコンドリア機能が亢進する
(第27回日本がん免疫学会総会 2023)
底生ザメ重鎖抗体IgNARの検出系構築と発現解析
(令和5年度日本生化学会九州支部例会 2023)

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Work history (9)：

2019 - 現在 Nagasaki University Cneter for Medical Innovation Professor
2017 - 2019 Hyogo College of Medicine Hyogo College of Medicine Research Professor
2012 - 2019 Nagasaki University Graduate School of Biomedical Sciences Associate Professor
2008 - 2012 Kyoto University Graduate School of Medicine Associate Professor
1999 - 2008 Kyoto University Graduate School of Biostudies Assistant Professor

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Awards (2)：

2022/11 - BRAVE FRONTIER Beyond Next Ventures Grand Prize
2004/04 - 稲盛財団伯楽賞免疫細胞の非ペプチド性抗原認識機構における構造・機能相関解析

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