Rchr
J-GLOBAL ID：200901015173058867   Update date: Aug. 07, 2024

Tomita Mikio

トミタ ミキオ | Tomita Mikio
Affiliation and department：
Tohoku Medical and Pharmaceutical University School of Pharmacy

About Tohoku Medical and Pharmaceutical University School of Pharmacy


Job title： Professor
Research field  (3)： Pharmacology ,  Medical biochemistry ,  Clinical pharmacy
Research keywords  (6)： 虚血再灌流 ,  敗血症 ,  生物薬剤学 ,  ischemia - reperfusion ,  Sepsis ,  Biopharmaceutics
Research theme for competitive and other funds  (33)：
  • 2013 - 2016 Evaluation of the intestinal secretion of indoxyl sulfate as a possible compensative excretion pathway in chronic kidney disease
  • 2012 - 2015 Improvement of inflammatory bowel diseases based on expression and functional changes of P-glycoprotein by methyl prednisolone and essential unsaturated fatty acids
  • 2009 - 2011 Improvement of inflammatory bowel diseases based on expression and functional changes of P-glycoprotein by methylpredonislone and essential fatty acids
  • 2006 - 2008 New Prediction System of Infective Disease Based on Changes in Expression and Function of ABC Transporter
  • 2003 - 2005 Improvement of intestinal drug absorption based on structural changes of tight junction and functional changes of P-glycoprotein
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Papers (32)：
  • Kaori Morimoto, Makoto Ishii, Yoshikazu Sugimoto, Takuo Ogihara, Mikio Tomita. Inhibitory Effect of Dextran Derivatives on Multidrug Resistance-Related Efflux Transporters <i>in Vitro</i>. Biological and Pharmaceutical Bulletin. 2022. 45. 8. 1036-1042
  • Kaori Morimoto, Momona Sasaki, Erika Oikawa, Maho Abe, Tatsuro Kikuchi, Makoto Ishii, Takuo Ogihara, Mikio Tomita. Intestinal Absorption of Alogliptin Is Mediated by a Fruit-Juice-Sensitive Transporter. Biological and Pharmaceutical Bulletin. 2021. 44. 5. 653-658
  • Maho Kumagai, Makoto Ishii, Kaori Morimoto, Mikio Tomita. Increased membrane permeation and blood concentration of 6-carboxyfluorescein associated with dysfunction of paracellular route barrier in the small intestine of ulcerative colitis model rats. Biopharmaceutics & Drug Disposition. 2020. 41. 3. 91-100
  • Aiko Iida, Shohei Ouchi, Toshio Oda, Jun Aketagawa, Yasuhiko Ito, Yusuke Takizawa, Mikio Tomita, Masahiro Hayashi. RETRACTED ARTICLE: Changes of Absorptive and Secretory Transporting System of (1 → 3) β-D-glucan Based on Efflux Transporter in Indomethacin-induced Rat (European Journal of Drug Metabolism and Pharmacokinetics, (2015), 40, 1, (29-38), 10.1007/s13318-014-0174-0). European Journal of Drug Metabolism and Pharmacokinetics. 2018. 43. 6. 769
  • Aiko Iida, Shohei Ouchi, Toshio Oda, Jun Aketagawa, Yasuhiko Ito, Yusuke Takizawa, Mikio Tomita, Masahiro Hayashi. Changes of Absorptive and Secretory Transporting System of (1 -> 3) beta-D-glucan Based on Efflux Transporter in Indomethacin-induced Rat. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS. 2015. 40. 1. 29-38
ｍore...
MISC (93)：
  • 富永 雄太, 森本 かおり, 宮本 将成, 柏倉 正太, 高橋 昂, 佐野 芳美, 矢野 健太郎, 荻原 琢男, 富田 幹雄. インドキシル硫酸の代償性排泄経路としての消化管分泌の関与. 日本腎臓病薬物療法学会誌. 2015. 4. 2. S170-S170
  • Mikio Tomita, Yusuke Takizawa, Atsushi Kanbayashi, Hiroyuki Murata, Ayako Tanaka, Mariko Nakaike, Megumi Hatanaka, Tomomi Kai, Masahiro Hayashi. Suppression of efflux transporters in the intestines of endotoxin-treated rats (Retraction of vol 428, pg 1, 2012). INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2014. 465. 1-2. 479-479
  • Mikio TOMITA. Impact of Intestinal Drug Absorption Enhancement in Drug Delivery System. 2012. 59. 1-11
  • 土井 信幸, 富田 幹雄, 木村 あおい, 林 正弘. アシルカルニチンの吸収促進作用の腸管部位差. 日本薬剤学会年会講演要旨集. 2011. 26年会. 151-151
  • 木村 あおい, 富田 幹雄, 土井 信幸, 新井 友里, 吉田 未紀, 林 正弘. アシルカルニチンによるTight junctionおよびABCトランスポーター機能変化における濃度依存性と寄与率の変動. 日本薬剤学会年会講演要旨集. 2011. 26年会. 171-171
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Books (7)：
  • 医薬品トキシコロジー
    南江堂 2006
  • 薬の運命、スタンダード薬学シリーズ、薬と疾病
    (東京化学同人)日本薬学会編 2005
  • トランスポーターを介さない消化管吸収
    月刊薬事 2001
  • バィオミメティックスハンドブック(共著)
    株式会社エヌ・ティー・エス 2000
  • 物理化学的視点からみた薬物の吸収
    月刊薬事 2000
ｍore...
Works (1)：
  • 小腸移植を支えるためのドラッグデリバリーシステムを利用した虚血再灌流障害の克服
    2003 -
Education (6)：
  • - 1992 Tokyo University of Pharmacy and Life Sciences Graduate School of Pharmacy
  • - 1992 Tokyo University of Pharmacy and Life Science Graduate School, Division of Pharmaceutical Sciences Biopharmaceuties
  • - 1988 Tokyo University of Pharmacy and Life Sciences Graduate School of Pharmacy
  • - 1986 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
  • - 1986 Tokyo University of Pharmacy and Life Science Faculty of Pharmaceutical Science
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Professional career (1)：
  • Philosophy of Doctor (Tokyo University of Pharmacy and Life Science)
Work history (4)：
  • 1996 - 1998 Harvard Medical School
  • 1988 - 1990 Akita University School of Medicine
  • 1988 - 1990 Research Associate, School of
  • Medicine, Akita University
Committee career (1)：
  • 日本臓器保存生物医学会 評議員
Awards (4)：
  • 2003 - 吉田仲子研究賞
  • 2003 - Yoshida Nakako Memorial Bioscience Study Foundation
  • 2000 - 加藤記念バイオサイエンス研究振興財団
  • 2000 - Kato Memorial Bioscience Study Foundation
Association Membership(s) (7)：
日本薬剤学会 ,  日本炎症・再生医学会 ,  日本臓器保存生物医学会 ,  日本消化吸収学会 ,  日本DDS学会 ,  日本薬物動態学会 ,  日本薬学会
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