Rchr
J-GLOBAL ID:200901015795091071
Update date: Oct. 25, 2024
Murohara Toyoaki
Murohara Toyoaki
Affiliation and department:
Job title:
Professor
Research field (1):
Cardiology
Research keywords (11):
代謝異常と循環器疾患
, Renin-Angiotensin System
, Hyperlipidemia
, Hypertension
, Cardiovascular Medicine
, Bone marrow stem cell
, Endothelial cell
, Regenerative Medicine
, Therapeutic Angiogenesis
, Vascular Regenerarion
, Vascular Biology
Research theme for competitive and other funds (70):
- 2022 - 2025 脂肪組織由来間葉系前駆細胞を用いたリンパ浮腫に対するリンパ管新生療法の開発研究
- 2022 - 2025 肺細動脈内皮細胞で特徴的変化を示す分子に着目した肺高血圧症への新規治療戦略の開発
- 2021 - 2024 新規抗炎症性アディポカインによる心臓病、腎臓病制御機構の解明
- 2021 - 2024 劇症型心筋炎における急性期管理法の確立および低侵襲早期診断マーカーの探索と開発
- 2021 - 2024 ホルモン連関とクローン性造血から探る糖尿病性心筋症の原因解析
- 2020 - 2024 Role of myokines in preventing the development of age-related diseases
- 2020 - 2023 脂肪組織由来間葉系前駆細胞を用いた血管新生療法の分子基盤探索
- 2020 - 2023 心臓の硬化を制御するG蛋白質共役受容体の機能解明と心不全治療薬シーズの探索
- 2019 - 2022 Glucagon-dependent autonomic regulatory system and its role in cardiovascular disease
- 2018 - 2021 Role of glucagon in diabetic cardiomyopathy and angiogenesis
- 2017 - 2020 The potential of omentin as therapeutic agents for cardiovascular disease.
- 2017 - 2020 Functions of Nitric Oxide and Endothelium-derived Hyperpolarizing Factor are impaired in Poor Run-off Autogenous Rabbit Arterial Grafts
- 2017 - 2020 Role of the novel myokine myonectin in regulation of ischemic heart disease
- 2017 - 2020 Role of VEGF165b, an inhibitory vascular endothelial growth factor splice variant, in pulmonary hypertension
- 2016 - 2020 Pathophysiological significance of the Klotho-FGF system in myocardial diseases
- 2017 - 2019 脂肪組織由来間葉系前駆細胞を用いた誘導心筋細胞による心筋再生療法の開発
- 2016 - 2019 Regulation of pathological vascular remodeling by a novel adipocytokines
- 2016 - 2019 Role of aging regulatory protein WRN in cardiac fibrosis
- 2015 - 2018 Evaluation by Frequency Analysis of Surface Electrocardiogram and Rotor Mapping in Left Atrum
- 2014 - 2017 The role of omentin in the vascualr disease
- 2014 - 2017 Novel molecular mechanism of Rho related kinase modifying heart failure condition and development of therapeutic drug
- 2014 - 2017 Role of the novel adipocytokine in regulation of cardiovascular disease
- 2014 - 2017 自己脂肪組織由来幹細胞を用いた心血管系再生医療の総合的開発研究
- 2015 - 2016 Role of C1q/TNF-related protein 1 in ischemic heart disease
- 2015 - 2016 細胞移植による劇症型心筋炎に対する心筋保護療法の試み
- 2013 - 2016 Pathophysiological significance of cathepsin K in dilated cardiomyopathy
- 2013 - 2016 Regulation of Notch signal pathway in adipogenesis
- 2013 - 2016 Cardiac myocyte-derived follistatin like 1 protects the kidney after subtotal nephrectomy
- 2013 - 2016 New therapeutic approach for targeting endothelium-derived hyper polarizing factor in the intimal hyperplasia of vein and artery grafts.
- 2012 - 2016 Therapeutic approach for diastolic heart failure through regenerative medicine
- 2012 - 2016 Impact of myocardial gene expression and exercise capacity in cardiomyopathy
- 2012 - 2014 The novel fat-derived hormone as a therapeutic target for acute coronary syndrome
- 2011 - 2014 Establishment of therapeutic lymphangiogenesis for lymphedema
- 2011 - 2014 Role of the myocyte-derived secreted factor in ischemic heart disease
- 2008 - 2013 Development of angiogenic cell therapy using iPS cell-derived vascular progenitor cells
- 2011 - 2013 Comprehensive And Therapeutic Strategy for Heart Failure Via Dipepidylpepidase-4 (DPP-4) Axis.
- 2010 - 2012 Individualized indication for Cardiac resynchronization therapy
- 2008 - 2011 血管再生障害からみた糖尿病性心筋症の基礎解析と新規治療法の開発
- 2009 - 2011 Therapeutic angiogenesis using adipose-derived regenerative cells
- 2009 - 2011 Identification and function analysis of micro RNAs in progression of heart failure
- 2009 - 2011 Adipocytokine is the new target of the strategy for the prevention of intimal hyperplasia
- 2006 - 2008 前駆細胞移植による血管再生療法の分子基盤探索と新規臨床応用に向けた展開研究
- 2007 - 2008 Development of angiogenetic and regenerative therapy with regulation of Notch signaling
- 2007 - 2008 Analysis for the association between mobilization of endothelial progenitor cells and prognosis in patients with acute myocardial infarction
- 2007 - 2008 To detect non-coding RNA related to heart failure
- 2006 - 2008 A role for the aryl hydrocarbon receptor in regulation of ischemia-induced angiogenesis
- 2006 - 2008 New Gene Therapy-Controlled Release of siRNA as to Midkine Inhibits the Intimal Hyperplasia in Vein Grafts
- 2006 - 2007 Pioglitazone, a peroxisome proliferator-activated receptor-gamma activator, attenuates atrial fibrosis and atrial fibrillation-promotion
- 2007 - 磁場と磁気ナノ粒子を用いた細胞シート工学とその再生医療への応用開発研究
- 2003 - 2005 バイオペースメーカー細胞の樹立と徐脈性不整脈の細胞治療
- 2000 - 2005 内皮前駆細胞移植を応用した虚血心筋の血管新生療法の開発
- 2004 - 2005 Therapeutic angiogenesis using noble human VEGF-E chimeric genes and autologous bone marrow mononuclear cells
- 2004 - 2005 Basic Research for Biological Pacemaker
- 2003 - 2005 Research on Establishment of Supporting System for In-Home Cardiovascular Medicine
- 2000 - 2005 Molecular Mechanisms of Heat Failure and Its Novel Therapeutic Strategies
- 2003 - 2004 Relationshio pregenitor cells derived from bone marrow and graft intimal hyperplasia
- 2003 - 2004 造血器腫瘍の病態に関わる癌遺伝子、癌抑制遺伝子変異の解析
- 2003 - 2004 造血器腫瘍の病態に関わる癌遺伝子、癌抑制遺伝子変異の解析
- 2002 - 2004 NEW TREATMENT FOR PULMONAY HYPERTENSION
- 2000 - 2004 血管新生と血管保護療法の開発に関する研究
- 2002 - 2003 細胞移植による血管新生療法の改良型開発のための基礎研究
- 2000 - 2002 末梢血幹細胞移植を応用した新しい虚血部血管新生療法の開発
- 2001 - 2002 Study of inhibitory effects of HMG Co A reductase inhibitor on in-vivo thrombus formation
- 2000 - 2001 コロニー刺激因子を用いた新しい虚血部血管新生療法の開発-内皮前駆細胞動員療法-
- 1999 - 2001 ヒト臍帯血からの内皮前駆細胞単離および分化誘導と血管新生療法への応用
- 2000 - 2001 Vascular remodeling in Kawasaki disease
- 2000 - 2001 Role of matrix metalloproteinase during arterial thrombus formation
- 1999 - 2000 自己骨髄単核細胞移植による心筋梗塞後血管新生療法の実験的試み
- 1998 - 2000 Pathophysiology in platelet-mediated thrombus model
- 1998 - 1999 高脂血症における組織虚血後の血管新生に関する研究
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Papers (1,070):
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Satoya Yoshida, Tatsuya Yoshida, Kohei Inukai, Katsuhiro Kato, Yoshimitsu Yura, Tomoki Hattori, Atsushi Enomoto, Koji Ohashi, Takahiro Okumura, Noriyuki Ouchi, et al. Protein kinase N promotes cardiac fibrosis in heart failure by fibroblast-to-myofibroblast conversion. Nature communications. 2024. 15. 1. 7638-7638
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Tomoya Iwawaki, Yasuya Inden, Satoshi Yanagisawa, Takayuki Goto, Shun Kondo, Masaya Tachi, Kei Hiramatsu, Ryota Yamauchi, Masafumi Shimojo, Yukiomi Tsuji, et al. A Novel Liver Fibrosis Marker FIB-5 Index Predicted Response to Cardiac Resynchronization Therapy and Prognostic Outcomes in Patients With Heart Failure. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc. 2024. 29. 5. e70004
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Yusuke Fujikawa, Katsuhiro Kato, Kazumasa Unno, Shingo Narita, Yusuke Okuno, Yoshitaka Sato, Mikito Takefuji, Toyoaki Murohara. Dynamic upregulation of retinoic acid signal in the early postnatal murine heart promotes cardiomyocyte cell cycle exit and maturation. Scientific reports. 2024. 14. 1. 20222-20222
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Toshikazu Ishihara, Katsuhiro Kato, Kotaro Matsumoto, Miyako Tanaka, Akitoshi Hara, Yukihiro Shiraki, Hidenori Morisaki, Yuya Urano, Ryota Ando, Kisuke Ito, et al. Meflin/ISLR is a marker of adipose stem and progenitor cells in mice and humans that suppresses white adipose tissue remodeling and fibrosis. Genes to cells : devoted to molecular & cellular mechanisms. 2024
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Ryo Watanabe, Hiroyuki Kato, Satoshi Yanagisawa, Taku Sakurai, Ryusuke Ota, Hisashi Murakami, Kenji Kada, Naoya Tsuboi, Yasuya Inden, Rei Shibata, et al. Long-Term Outcomes in Patients With Relatively High His-Bundle Capture Threshold After Permanent His-Bundle Pacing - A Multicenter Clinical Study. Circulation reports. 2024. 6. 8. 294-302
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MISC (1,149):
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中野 嘉久, 足立 史郎, 廣瀬 未来, 安達 健, 西山 軼群, 安田 健一郎, 吉田 雅博, 岩野 信吾, 八谷 寛, 近藤 隆久, et al. Refined CTプロトコールによる急性肺塞栓症1年後の残存血栓の検出. 日本肺高血圧・肺循環学会学術集会・日本小児肺循環研究会プログラム・抄録集. 2022. 7回・28回. 126-126
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西山 軼群, 足立 史郎, 安田 健一郎, 吉田 雅博, 中野 嘉久, 近藤 隆久, 室原 豊明. 肺動脈血栓内膜摘除術数年後に収縮性心内膜炎を発症した一例. 日本肺高血圧・肺循環学会学術集会・日本小児肺循環研究会プログラム・抄録集. 2022. 7回・28回. 139-139
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小林聖典, 六鹿雅登, 六鹿雅登, 奥村貴裕, 奥村貴裕, 平岩宏章, 平岩宏章, 近藤徹, 近藤徹, 室原豊明, et al. 高齢植込み型補助人工心臓装着患者の運動機能に関する検討. 人工臓器(日本人工臓器学会). 2020. 49. 2
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小林聖典, 奥村貴裕, 奥村貴裕, 平岩宏章, 平岩宏章, 近藤徹, 近藤徹, 六鹿雅登, 六鹿雅登, 藤本和朗, et al. LVAD装着術後患者の退院時下肢筋力は再入院と関連する. 日本心不全学会学術集会プログラム・抄録集. 2020. 24th (CD-ROM)
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大石英生, 奥村貴裕, 清水美帆, 竹内晴美, 荒尾嘉人, 加藤宏雄, 桑山輔, 羽賀智明, 山口尚悟, 横井剛, et al. Exercise and Nutritional Intervention in the Acute Phase of Cardiac/Intensive Care in Patients with Advanced Heart Failure. 日本循環器学会学術集会(Web). 2019. 83rd
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Patents (1):
-
Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue.
Professional career (2):
- 医学博士 (熊本大学)
- Medical Doctor (Kumamoto University)
Work history (12):
- 2004/10/01 - 現在 Nagoya University Program in Integrated Molecular Medicine Professor
- 2002/06/01 - Department of Cardiology, Nagoya University Graduate School of Medicine
- 1997/07/01 - 2002/05/31 Department of Internal Medicine III, Kurume University School of Medicine
- 1996/03/01 - 1997/06/30 Department of Cardiology, St. Elizabeth's Medical Center, Tufts University School of Medicine
- 1993/09/01 - 1996/02/28 Department of Physiology, Jefferson Medical School of Thomas Jefferson University
- 1992/07/01 - 1993/08/31 Saiseikai Kumamoto Hospital
- 1992/04/01 - 1992/06/30 Department of Cardiology, Kumamoto University Medical School
- 1987/04/01 - 1988/03/31 National Kumamoto Hospital
- 1986/10/01 - 1987/03/31 Department of Cardiology, Kumamoto University Medical School
- 1986/04/01 - 1986/09/30 Kumamoto Chuou Hospital
- 1985/12/01 - 1986/03/31 Miyazaki Prefectural Nobeoka Hospital
- 1985/05/01 - 1985/11/30 Department of Cardiology, Kumamoto University Medical School
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Association Membership(s) (8):
European Society of Cardiology
, 日本血管生物医学会
, 日本動脈硬化学会
, 日本心不全学会
, 日本高血圧学会
, Japanese Society of Internal Medicine
, American Heart Association
, Japanese Circulation Society
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