Watanabe Hirohisa

Affiliation and department：

Research field (1)： Neuroscience - general

Research keywords (9)： Dementia , Parkinson's disease , Multiple system atrophy , Frontotemporal lobar degeneration/amyotrophic lateral sclerosis , Aging , Brain network , Cohort and Registry , Information and mathematical neurology , Neuroradiology

Research theme for competitive and other funds (24)：

2022 - 2026 機能的MRIによる痙攣性発声障害の病態解明
2022 - 2025 パーキンソン病における尿酸パラドックスの病態解明
2021 - 2024 Development of diagnosis support system for Parkinson's disease by voice analysis
2021 - 2024 Elucidating the mechanism of sudden death in multiple system atrophy using serotonin imaging
2019 - 2024 A Cross-Sectional Study on Disease and Regional Diversity of Cognitive Impairment in Elderly Using Speech Analysis and Cerebral Blood Flow Activation

2017 - 2020 Pathological elucidation of tremor by various modality and modification by Focal Ultrasounds and Deep Brain Stimulation

2017 - 2020 Connectome map for epilepsy surgery originated by network imaging analysis and its justification by stereotactic electroencephalography (SEEG)

2017 - 2020 Development of new dimensional clinical neuroimaging method based on the waste clearance system of inner ear

2016 - 2019 Development of biomarkers of sleep disturbance in Parkinson's disease using salivary melatonin

2014 - 2019 Visualization of brain protein aging and clarification of the mechanisms of neural circuit breakdown

2015 - 2018 Randomized double blind multi center trial of hydrogen water for Parkinson's disease

2015 - 2018 The inhibitory change using double stimulation somatosensory evoked response in aging and Parkinsonian effects

2015 - 2018 Adult neurogenesis in the mouse models of ALS/FTLD

2015 - 2017 Analysis of temporal and spatial brain circuit using real-time simultaneous electroencephalography and functional magnetic resonance imaging

2014 - 2017 Innovation of novel preoperative planning called connectome map for new generation of subcortically functional surgery

2013 - 2016 To elucidate the pattern of progression in multiple system atrophy

2013 - 2016 Searching for factors associated with progression and prognosis in patients with sporadic amyotrophic lateral sclerosis

2013 - 2015 統合的脳MRIネットワーク解析によるALSの運動機能-前頭葉機能間関連性の解明

2012 - 2015 Efficacy of cholinesterase inhibitor drugs in early Parkinson's disease patients

2012 - 2015 Clarification of the involvement of leptin and ghrelin in cardiovascular dysautonomia and vision for treatment in Parkinson disease.

2012 - 2015 The association between non-motor symptom and visual hallucination in Parkinson disease

2010 - 2012 Establishing the biomarker of multiple system atrophy

2009 - 2011 Impaired pain processing in Parkinson's disease and its relative association with the non-motor symptom

2009 - 2011 Elucidation of the pathogenesis of visual halllucination in Parkinson's disease

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Papers (722)：

Ryunosuke Nagao, Yasuaki Mizutani, Sayuri Shima, Akihiro Ueda, Mizuki Ito, Junichiro Yoshimoto, Hirohisa Watanabe. Correlations between serotonin impairments and clinical indices in multiple system atrophy. European journal of neurology. 2024. 31. 3. e16158
Akihiko Takashima, Riki Koike, Yoshiyuki Soeda, Yusuke Fujioka, Shinsuke Ishigaki, Hirohisa Watanabe. Path integration deficits predict phosphorylated tau accumulation in the entorhinal cortex: Assessment of Braak stage I,II using 3D Virtual reality goggles. Alzheimer's & Dementia. 2023. 19. S22
Yusuke Yoshida, Takamasa Yokoi, Kazuhiro Hara, Hirohisa Watanabe, Hiroshi Yamaguchi, Epifanio Bagarinao, Michihito Masuda, Toshiyasu Kato, Aya Ogura, Reiko Ohdake, et al. <Editors' Choice> Pattern of THK 5351 retention in normal aging involves core regions of resting state networks associated with higher cognitive function. Nagoya journal of medical science. 2023. 85. 4. 758-771
Chisako Iriyama, Kenichiro Murate, Sachiko Iba, Akinao Okamoto, Naoe Goto, Hideyuki Yamamoto, Toshiharu Kato, Keichiro Mihara, Takahiko Miyama, Keiko Hattori, et al. Utility of cerebrospinal fluid liquid biopsy in distinguishing CNS lymphoma from cerebrospinal infectious/demyelinating diseases. Cancer medicine. 2023. 12. 16. 16972-16984
Yasuaki Mizutani, Kazuki Nawashiro, Reiko Ohdake, Harutsugu Tatebe, Sayuri Shima, Akihiro Ueda, Junichiro Yoshimoto, Mizuki Ito, Takahiko Tokuda, Tatsuro Mutoh, et al. Enzymatic properties and clinical associations of serum alpha-galactosidase A in Parkinson's disease. Annals of clinical and translational neurology. 2023

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MISC (103)：

渡辺宏久, 島さゆり, 水谷泰彰, 植田晃広, 伊藤瑞規. 病態と対策-Long COVID : Pathogenesis and Therapeutic Approach-特集 COVID-19 : 脳神経内科医が診るための最新知識2022 ; Long COVID. Brain and nerve. 2022. 74. 7. 879-884
伊藤瑞規, 水谷泰彰, 植田晃広, 渡辺宏久. パーキンソン病関連疾患と鑑別. 難病と在宅ケア. 2022. 27. 10. 51-55
Akihiro Ueda, Mayumi Senda, Kunihisa Kato, Syunske Adachi, Konoka Esaka, Yuji Tsujimura, Syuko Nakano, Kazutaka Hayashi, Fumihiko Banno, Koichi Kikuchi, et al. Long duration prognosis of hypertrophic pachymeningitis. JOURNAL OF THE NEUROLOGICAL SCIENCES. 2021. 429
長尾龍之介, 中野頌子, 林和孝, 加藤邦尚, 坂野文彦, 菊池洸一, 東篤宏, 前田利樹, 村手健一郎, 廣田政古, et al. 多系統萎縮症におけるセロトニントランスポーター可視化. 臨床神経学. 2021. 61. Suppl. S304-S304
前田利樹, 坂野文彦, 水谷泰彰, 長尾龍之介, 新美芳樹, 島さゆり, 植田晃広, 乾好貴, 武藤多津郎, 外山宏, et al. パーキンソン病における一次視覚野の血流低下には舌状回を中心とした視覚関連領域の血流低下が影響する. パーキンソン病・運動障害疾患コングレスプログラム・抄録集. 2021. 14th

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Books (6)：

Clinical Assessment of the Autonomic Nervous System. Findings of MIBG Cardiac Scintigraphy: Dementia with Lewy Bodies and Related Dementia.
Springer 2016
Clinical Assessment of the Autonomic Nervous System. Technical Considerations for MIBG Cardiac Scintigraphy.
Springer 2016
渡辺宏久、中村友彦、勝野雅央、祖父江元
MEDICAL VIEW 2016
神経内科外来シリーズ、多系統萎縮症
MEDICAL VIEW 2016
薬学生のための新臨床医学
廣川書店 2008

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Professional career (1)：

博士(医学) (名古屋大学)

Work history (6)：

2019/04 - 現在 Fujita Health University Department of Neurology Professor
2013/12 - 2019/03 Nagoya University Brain and Mind Research Center Division Designated professor
2013/06 - 2013/11 Nagoya University Graduate School of Medicine Designated professor
2009/01/01 - 2013/05/31 Nagoya University Nagoya University Hospital Neurology Lecturer
2007/04/01 - 2008/12/31 Nagoya University Nagoya University Hospital Neurology Assistant Professor

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Association Membership(s) (13)：

Movement Disorders Society , MDS-J , America Academy of Neurology , Japan Society for Dementia Research , 日本内科学会 , 自律神経学会 , 脳卒中学会 , 神経治療学会 , 日本神経学会 , 日本核医学会 , 日本神経感染症学会 , 日本神経摂食嚥下・栄養学会 , 日本神経精神医学会

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