Rchr
J-GLOBAL ID：200901017354350309
Update date: Nov. 10, 2024
Itoh Tohru
イトウ トオル | Itoh Tohru
Affiliation and department：
Job title：
Associate Professor
Other affiliations (1)：
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Institute for Quantitative Biosciences, The University of Tokyo
Laboratory of Cell Growth and Differentiation
Research field (3)：
Developmental biology
, Cell biology
, Molecular biology
Research keywords (6)：
tissue remodeling
, biliary epithelial tissue
, bile duct
, シグナル伝達
, 肝臓
, 幹細胞
Research theme for competitive and other funds (15)：
- 2022 - 2025 障害後の肝臓に現れる特殊な胆管細胞が線維化および発癌に寄与する可能性の検証
- 2021 - 2024 ダイナミックに変貌する胆管の上皮組織構造を維持するメカニズムの解明
- 2018 - 2022 Study on the roles and mechanisms of adaptive remodeling of the intrahepatic biliary epithelial tissue that supports liver regeneration
- 2017 - 2019 Cracking the dying code that provokes stem/progenitor cell-dependent liver regeneration
- 2015 - 2017 肝細胞死に応答して肝臓の線維化および再生を誘導・制御する新規ストローマ細胞の解析
- 2014 - 2017 Cellular interaction in liver inflammation and regeneration
- 2014 - 2016 肝臓上皮組織の再生・維持機構の生体内多次元イメージング解析
- 2012 - 2015 Elucidation of the regulatory mechanisms for liver regeneration and pathogenesis based on the intercellular signaling network
- 2010 - 2015 Studies on microenvironment that regulates hematopoietic cells
- 2012 - 2014 新規可視化法を用いた、正常時と障害時における胆管3次元ダイナミクス解析
- 2010 - 2012 Cellular interaction in liver development and pathogenesis
- 2010 - 2011 Investigation of the signal network regulating adult liver progenitor cells(oval cells) involved in liver regeneration
- 2005 - 2009 Mechanism of liver development
- 2006 - 2007 Stat3活性化を制御する新規分子Eziの生体内における機能の解析
- 1998 - 1999 サイトカインレセプターシグナル伝達による細胞増殖・分化の制御機構の解析
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Papers (58)：
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Yasuhiro Nakano, Eiko Saijou, Tohru Itoh, Minoru Tanaka, Atsushi Miyajima, Taketomo Kido. Development of a high throughput system to screen compounds that revert the activated hepatic stellate cells to a quiescent-like state. Scientific Reports. 2024. 14. 1. 8536
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Yasuhiro Nakano, Tohru Itoh, Minoru Tanaka, Atsushi Miyajima, Taketomo Kido. Development of a high throughput system to screen compounds that revert the activated hepatic stellate cells to a quiescent-like state. bioRxiv. 2023
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Nobutaka Takeda, Atsunori Tsuchiya, Masaki Mito, Kazuki Natsui, Yui Natusi, Yohei Koseki, Kei Tomiyoshi, Fusako Yamazaki, Yuki Yoshida, Hiroyuki Abe, et al. Analysis of distribution, collection, and confirmation of capacity dependency of small extracellular vesicles toward a therapy for liver cirrhosis. Inflammation and Regeneration. 2023. 43. 1. 48-48
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Yasuhiro Nakano, Sachie Nakao, Minako Sueoka, Daigo Kasahara, Yuri Tanno, Hideaki Sumiyoshi, Tohru Itoh, Atsushi Miyajima, Katsuto Hozumi, Yutaka Inagaki. Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice. Communications Biology. 2022. 5. 1
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Minami Yamada, Hajime Okada, Masatsugu Ema, Yamato Kikkawa, Atsushi Miyajima, Tohru Itoh. KLF5-regulated extracellular matrix remodeling secures biliary epithelial tissue integrity against cholestatic liver injury. bioRxiv. 2022
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MISC (13)：
Books (2)：
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未来探究2050 : 東大30人の知性が読み解く世界
日経BP日本経済新聞出版本部,日経BPマーケティング (発売) 2021 ISBN:9784532358785
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代謝系臓器(再生医療叢書5)
朝倉書店 2012 ISBN:9784254360752
Lectures and oral presentations (9)：
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Essential Role of KLF5 in Regulating Biliary Epithelial Tissue Remodeling Against Cholestatic Liver Diseases
(SLAM (Summer Liver Academy Meeting) 2024 2024)
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肝臓の病態と再生における胆管組織リモデリングの役割と制御機構
(第96回 日本生化学会大会 2023)
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透明化技術を用いた肝臓の3次元イメージング
(第51回 日本臨床分子形態学会総会・学術集会 (教育講演1) 2019)
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多次元イメージング法による肝内胆管系の動態解析
(平成29年度薬物動態談話会 第40年会 (シンポジウム1) 2017)
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細胞系譜解析による肝幹/前駆細胞の実在と肝再生への寄与の検証
(第23回 肝細胞研究会 (シンポジウム1、 S1-1) 2016)
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Professional career (1)：
Committee career (2)：
- 2023/01 - 現在 Hepatology Communications (AASLD) Editorial Board member
- 2017 - 現在 肝細胞研究会 世話人
Association Membership(s) (5)：
日本再生医療学会
, The American Society for Biochemistry and Molecular Biology (ASBMB)
, 肝細胞研究会
, 日本分子生物学会
, 日本生化学会
