Yada Toshihiko

Affiliation and department：
Job title：センター長
Homepage URL (1)： http://kaken.nii.ac.jp/ja/r/60166527

Research field (9)： Clinical pharmacy , Physiology , Metabolism and endocrinology , Neuroanatomy and physiology , Pharmacology , Psychiatry , Orthopedics , Medical biochemistry , Neurology

Research keywords (28)：包括脳ネットワーク , 糖尿病 , インスリン分泌 , 膵β細胞 , グルコース , PACAP , Ca^<2+> , グレリン , レプチン , β細胞 , 膵島 , 摂食中枢 , NPYニューロン , 免疫組織化学 , 脂肪細胞 , 弓状核 , 摂食 , インスリン , サイクリックAMP , 細胞内カルシウム , オ-トクリン , パッチクランプ , 肥満 , GKラット , 小胞体 , ランゲルハンス島 , 視床下部 , cAMP

Research theme for competitive and other funds (44)：

2019 - 2022 Establishing appetitive vagal afferent nerve for ameliorating anorexia, frailty, cancer and depression
2019 - 2022 Central and organ mechanisms for anti-obesity/diabetes effects of rare sugar allulose
2016 - 2018 Molecular mechanism for highly sensitive response to peripheral hormones in hypothalamic neurons and homeostatic role
2014 - 2017 GLP-1 and insulin synergize to activate vagal afferent nerves leading to central regulation of metabolism, feeding and blood pressure
2012 - 2014 Regulation by Na-K pump of glucose-sensitive NPY neurons and feeding behavior, and its dysfunction in hyperphagia and obesity

2011 - 2013 Glucose metabolism in ghrelin conditional KO mice

2010 - 2012 Studies on signal activating systems induced by an anorexigenicappetitekine, Nesfatin-1

2011 - 2011 Regulation by nesfatin and oxytocin of feeding, metabolism and circadian rhythm, as a basis for treating life style-related diseases

2011 - 2011 摂食行動を創出する新規分子と神経回路の解明

2010 - 2011 Novel function of oxytocin : its anorectic neuronal pathway and(patho) physiological role in regulating feeding

2009 - 2010 グルコースとホルモン情報を統合する膵β細胞Kv・TRPチャネルのセンサー機構

2008 - 2010 IKdelay is related to a novel GLP-1 pathway that is KATP-independent insulin secretion.

2008 - 2010 Effective strategy to treat type 2 diabetes by blockade of ghrelin signaling in islet β-cells

2008 - 2010 Ghrelin : its status as a pancreatic hormone, mechanisms by which it regulates insulin release and glucose metabolism, and its application for treating diabetes.

2007 - 2008 TRP・Kvチャネルを介した新規グルコースセンシング-インスリン分泌連関

2006 - 2008 Molecular basis on function and clinical implication of neuropeptide PACAP

2006 - 2007 Analysis of the relationship between cannabinoid system inpancreatic islets and hyperinsulinemia

2006 - 2007 Inputs and outputs of NPY and BDNF neurons in the hypothalamus and their implication in feeding and metabolic regulation

2003 - 2007 Novel signaling function of adipocytes

2004 - 2005 Identification of the impaired sites of cAMP pathways in sulfonylurea receptor 1 knockout islets.

2004 - 2005 Regulation by endogenous ghrelin of insulin release, feeding and glucose metabolism

2003 - 2005 Molecular pharmacological aspects of the neuropeptide PACAP in brain and pancreas

2002 - 2004 Prevention of delayed neuronal cell death by PACAP and its molecular mechanism

2002 - 2003 Study on multimolecular modulations of ATP-sensitive K^+ channels in pancreatic β-cells and their disharmony in diabetes.

2000 - 2002 Studies of cellular physiology and molecular endocrinology of orexin and MCH.

2000 - 2002 Regulation by glucose and insulin of the neurons in feeding-regulatory centers and its alteration in obesity and diabetes

2000 - 2001 Studies on multimolecular modulation of ATP-sensitive K^+ channels in pancreatic β-cells

1999 - 1999 食欲・代謝中枢の単一ニューロン活動計測と調節因子同定・作用機構解析の実験法の確立

1998 - 1999 覚醒剤・コカイン・PCPによる薬物依存:A10神経を用いた分子細胞生理学的研究

1998 - 1999 Functional significance of PACAP receptors in regulating secretion and synthesis of vasopressi

1998 - 1999 FACTORS OF STRUCTURE AND FUNCTION COUPLING BETWEEN SUR/KIR6.2IN PANCREATIC B-CEELS

1997 - 1999 Functional significance of PACAP in inhibiting neuronal cell death by using gene targeting method

1997 - 1998 Control of glucose metabolism by PACAP : stimulation of insulin secretion and potentiation of insulin action

1997 - 1997 ATP-活性化K^+チャネルを介した新規インスリン分泌制御機構についての研究

1995 - 1997 Cell Biological Study for the Mechanism of Osteogenesis by Electromagnetic Fields.

1996 - 1996 膵β細胞小胞体Ca^<2+>ポンプとCa^<2+>放出チャネルの機能協関とインスリン分泌制御

1995 - 1995 筋細胞壊死におけるCa^<2+>依存性機構の解明

1995 - 1995 膵β細胞小胞体Ca^<2+>ポンプとCa^<2+>放出チャネルの機能協関とインスリン分泌制御

1994 - 1995 Extraordinarily Potent Insulinotropin PACAP : Its Characterization as a Pancreatic Peptide and Action Mechanisms in Islet beta-Cells

1993 - 1993 新しいインスリン分泌調節ペプチドとしてのPACAPの役割と膵beta細胞作用機構

1991 - 1992 Argininosuccinate as a possible neuromodulator and localization of its metabolizing enzymes

1990 - 1991 Characteristics of the Ca channel from pancreatic B-cells and its modulation by glucose

1990 - 1990 膵β細胞におけるグルコ-ス刺激に対する細胞内Ca応答の解析

1989 - 1990 単一細胞の分泌・収縮と細胞内機能制御因子群の電気的光学的同時測定装置の試作

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Papers (177)：

Masanori Nakata, Yuto Yamaguchi, Hikaru Monnkawa, Midori Takahashi, Boyang Zhang, Putra Santoso, Toshihiko Yada, Ikuro Maruyama. 1,5-Anhydro-D-Fructose Exhibits Satiety Effects via the Activation of Oxytocin Neurons in the Paraventricular Nucleus. International journal of molecular sciences. 2023. 24. 9
Wanxin Han, Lei Wang, Kento Ohbayashi, Masakazu Takeuchi, Libbey O'Farrell, Tamer Coskun, Yermek Rakhat, Daisuke Yabe, Yusaku Iwasaki, Yutaka Seino, et al. Glucose-dependent insulinotropic polypeptide counteracts diet-induced obesity along with reduced feeding, elevated plasma leptin and activation of leptin-responsive and proopiomelanocortin neurons in the arcuate nucleus. Diabetes, Obesity and Metabolism. 2023. 25. 6. 1534-1546
Lei Wang, Shigetomo Suyama, Samantha A. Lee, Yoichi Ueta, Yutaka Seino, Geoffrey W. G. Sharp, Toshihiko Yada. Fasting inhibits excitatory synaptic input on paraventricular oxytocin neurons via neuropeptide Y and Y1 receptor, inducing rebound hyperphagia, and weight gain. Frontiers in Nutrition. 2022. 9
Yermek Rakhat, Kentaro Kaneko, Lei Wang, Wanxin Han, Yutaka Seino, Daisuke Yabe, Toshihiko Yada. d-Allulose Inhibits Ghrelin-Responsive, Glucose-Sensitive and Neuropeptide Y Neurons in the Arcuate Nucleus and Central Injection Suppresses Appetite-Associated Food Intake in Mice. Nutrients. 2022. 14. 15
Rakhat Yermek, Lei Wang, Kentaro Kaneko, Wanxin Han, Yutaka Seino, Daisuke Yabe, Toshihiko Yada. D-Allulose cooperates with glucagon-like peptide-1 and activates proopiomelanocortin neurons in the arcuate nucleus and central injection inhibits feeding in mice. Biochemical and biophysical research communications. 2022. 613. 159-165

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MISC (17)：

Shigetomo Suyama, Toshihiko Yada. New insight into GABAergic neurons in the hypothalamic feeding regulation. Journal of Physiological Sciences. 2018. 68. 6. 717-722
木村博昭, 臼井文武, 唐澤直義, 川島晃, 笠原忠, 鈴木幸一, 岩崎有作, 矢田俊彦, 高橋将文. 高脂肪食による肥満・メタボリック病態における免疫プロテアソーム欠損の有益な効果. 日本内分泌学会雑誌. 2016. 92. 1. 215-215
Kohno, Daisuke, Koike, Miho, Ninomiya, Yuzo, Kojima, Itaru, Kitamura, Tadahiro, Yada, Toshihiko. Sweet Taste Receptor Serves to Activate Glucose- and Leptin-Responsive Neurons in the Hypothalamic Arcuate Nucleus and Participates in Glucose Responsiveness. FRONTIERS IN NEUROSCIENCE. 2016. 10. 502
木村博昭, 臼井文武, 唐澤直義, 川島晃, 笠原忠, 岩崎有作, 矢田俊彦, 高橋将文. 免疫プロテアソーム欠損は高脂肪食による肥満を抑制する. 肥満研究. 2015. 21. Suppl. 204-204
Central action of oxytocin. 2014. 39. 1. 20-25

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Work history (7)：

2022/04 - 現在岐阜大学大学院医学系研究科糖尿病・内分泌代謝内科学客員教授
2018/04 - 現在鹿児島大学大学院医学研究科漢方薬理学客員教授
2018/04 - 現在神戸大学大学院医学研究科糖尿病・内分泌内科学客員教授
2018/04 - 現在関西電力医学研究所統合生理学研究センター統合生理学研究部センター長部長
2018/04 - 現在 Jichi Medical University School of Medicine

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