Kishihara Kenji

キシハラケンジ | Kishihara Kenji

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://immunology.hosp.med.tokushima-u.ac.jp/immunology/system/top/index.php

Research field (2)： Immunology , Parasitology

Research keywords (9)：感染防御 , シグナル伝達 , 自然免疫 , 生体防御 , 免疫学 , Infection , Signal transduction , Immune response , Immunology

Research theme for competitive and other funds (31)：

2008 - 2010 Development of a culture system to selectively induceγ δT-lymphocytes from embryonic and hematopoietic stem cells
2006 - 2007 Establishment of the system to control T lymphocyte functions using Notch ligands
1994 - 2007 発生工学的手法による生体防御系の解析に関する研究
1994 - 2007 Study on Analysis of host defense system by transgenic and gene trageting technology
2004 - 2005 Notchレセプター糖鎖転移酵素フリンジのTリンパ球特異的ジーン・ターゲティング

2004 - 2005 Notch分子によるヘルパーTリンパ球分化・活性化制御機構の解明

2001 - 2005 サイトカインのシグナル制御機構とその破綻

2003 - 2004 Jagged1を制御することによる癌免疫の増強に関する研究

1999 - 2004 生体防御系におけるγδT細胞の役割に関する研究

1999 - 2004 Study on roles of γδT cells in host defense system

2002 - 2003 Tリンパ球の生死を規定する分子機構の解明

2001 - 2003 Analysis of pathogenesis and establishment of novel diagnostic strategy of oral mucosal diseases by T cell receptorbased analysis

2000 - 2002 Identification of oral squamous cell carcinoma-associated antigens recognized by T cells

2000 - 2001 SELECTIVE GENE TRGETING OF TCR Vδ GENES AND ANALYSIS OF THE KNOCKOUT MICE

1998 - 1999 GENE TARGETING OF PROTEIN TYROSINE PHOSPHATASE PTP-J

1997 - 1999 Elucidation of the immunological mechanism in tubulointerstitial damage. - investigation with knockout mouse

1997 - 1999 Identification of oral squamous cell carcinoma-associated antigens recognized by T cells

1997 - 1998 THE ANALYSIS OF THE MECHANISM OF ALLOGRAFT REJECTION USING KNOCK OUT MICES

1994 - 1998 免疫細胞の分化・機能におけるチロシンホスファターゼの役割に関する研究

1996 - 1997 T細胞に発現される新しいチロシンホスファターゼの遺伝子と機能の解析

1996 - 1997 A study of defense mechanism against the infection of intestinal nematode by using knockout mice

1996 - 1996 T細胞活性化のシグナル伝達

1995 - 1995 T細胞活性化のシグナル伝達

1995 - 1995 遺伝子ターゲティングマウスにおける免疫応答異常の解析

1994 - 1995 SUBTRACTION PCR CLONING OF NOVEL LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE PHOSPHATASE GENES

1994 - 1995 The Role of CD45 in Leukocyte Differentiation and Function

1994 - 1994 T細胞活性化のシグナル伝達

1994 - 1994 特異遺伝子欠損マウスにおける免疫応答異常の解析

1994 - Study on roles of protein tyrosine phosphatases in immune cells

健康食品(機能性食品)の開発・評価

Development and estimation of health care foods

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Papers (22)：

Paulina Kulig, Stephanie Musiol, Sandra Nicole Freiberger, Bettina Schreiner, Gabor Gyulveszi, Giancarlo Russo, Stanislav Pantelyushin, Kenji Kishihara, Francesca Alessandrini, Thomas Kundig, et al. IL-12 protects from psoriasiform skin inflammation. NATURE COMMUNICATIONS. 2016. 7
Ishifune C, Maruyama S, Sasaki Y, Yagita H, Hozumi K, Tomita T, Kishihara K, Yasutomo K. Differentiation of CD11c+ CX3CR1+ cells in the small intestine requires Notch signaling. Proceedings of the National Academy of Sciences of the United States of America. 2014. 111. 16. 5986-5991
Takuhiro Uto, Ayana Sakamoto, Nguyen Huu Tung, Tsukasa Fujiki, Kenji Kishihara, Shigeru Oiso, Hiroko Kariyazono, Osamu Morinaga, Yukihiro Shoyama. Anti-Proliferative Activities and Apoptosis Induction by Triterpenes Derived from Eriobotrya japonica in Human Leukemia Cell Lines. International journal of molecular sciences. 2013. 14. 2. 4106-20
Takuhiro Uto, Ayana Sakamoto, Nguyen Huu Tung, Tsukasa Fujiki, Kenji Kishihara, Shigeru Oiso, Hiroko Kariyazono, Osamu Morinaga, Yukihiro Shoyama. Anti-Proliferative Activities and Apoptosis Induction by Triterpenes Derived from Eriobotrya japonica in Human Leukemia Cell Lines. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2013. 14. 2. 4106-4120
Lian Gaojian, Arimochi Hideki, Kitamura Akiko, Nishida Jun, Li Shigen, Kishihara Kenji, Maekawa Yoichi, Yasutomo Koji. Manipulation of CD98 resolves type 1 diabetes in nonobese diabetic mice. Journal of immunology (Baltimore, Md. : 1950). 2012. 188. 5. 2227-34

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MISC (209)：

S. Musiol, P. Kulig, S. Freiberger, B. Schreiner, G. Gyulveszi, G. Russo, K. Kishihara, F. Alessandrini, B. Becher, S. Haak. The Ying & Yang of IL23p40 in psoriatic plaque formation. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2016. 136. 9. S261-S261
Gaojian Lian, Hideki Arimochi, Akiko Kitamura, Jun Nishida, Shigen Li, Kenji Kishihara, Yoichi Maekawa, Koji Yasutomo. Manipulation of CD98 resolves type 1 diabetes in nonobese diabetic mice. Journal of Immunology. 2012. 188. 2227-2234
Muhammad Shamsul Alam, Yoichi Maekawa, Akiko Kitamura, Kenji Tanigaki, Takayuki Yoshimoto, Kenji Kishihara, Kenji Kishihara, Koji Yasutomo. Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor. Proceedings of the National Academy of Sciences of the United States of America. 2010. 107. 13. 5943-5948
Watanabe, K, Kishihara, K, Hamano, S, Koga, M, Nomoto, K, Tada, I. Strongyloides ratti: implication of mast cell-mediated expulsion through FcεRI-independent mechanisms. Parasite. 2009. 16. 3. 209-214
浜田聡, 梅村正幸, 塩野健, 原博満, 岸原健二, 田中健照, 黛宏和, 松崎吾朗. Listeria monocytogenes感染に対するVδ1+γδ型T細胞の感染防御機構. 補体シンポジウム講演集. 2008. 45. 109-109

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Books (9)：

Control Mechaism of Stress and Emotion
Neuroendvrine-Based Studies Elsevies 1999
Control Mechaism of Stress and Emotion
Neuroendvrine-Based Studies Elsevies 1999
ノックアウトマウス・データブック
中山書店 1997
KEY WORD 1996-'97 炎症・免疫系
先端医学社 1996
食物アレルギー
光生館 1995

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Works (2)：

免疫ミルクの抗炎症作用に関する共同研究
1997 - 2002
Joint Research on anti-inflammatory activity of immune milk
1997 - 2002

Education (4)：

- 1989 Kyushu University
- 1989 Kyushu University Graduate School, Division of Medical Sciences Immunology
- 1984 Kyushu University School of Agriculture
- 1984 Kyushu University Faculty of Agriculture Department of Agricultual Chemistry

Professional career (1)：

Doctor (Medical Science) (Kyushu University)

Work history (9)：

2008/04 - 現在 Nagasaki International University Division of Immunology, Department of Pharmacy, Faculty of Pharmaceutical Sciences Professor
2003/10 - 2008/03 The University of Tokushima Institute of Health Biosciences The University of Tokushima Graduate School Assoc. Prof.
2002 - 2003 The University of Tokushima Faculty of Medicine
2002 - 2003 Assistant Professor, School of Medicine,
2003 - - 同助教授

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Committee career (1)：

1996 - 現在日本免疫学会評議員

Association Membership(s) (11)：

日本寄生虫学会 , 米国免疫学会 (AAI) , 日本生体防御学会 , 日本分子生物学会 , 日本細菌学会 , 日本免疫学会 , The American Assosiation of immunologists , Japanese Society for Bio-Defense Research , The Molecular Biology Society of Japan , Japanese Society for Bacteriology , The Japanese Society for Immunology

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