Takahashi Ken

タカハシケン | Takahashi Ken

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： https://ken-takahashi.net/

Research field (6)： Physiology , Biomaterials , Biomedical engineering , Bio-, chemical, and soft-matter physics , Clinical pharmacy , Physiology

Research keywords (10)： organ on a chip , ischemia-reperfusion injury , myocardial infarction , Cardiovascular diseases , Biomedical Engineering , Space Medicine , Mechanobiology , Regenerative Medicine , Biophysics , Physiology

Research theme for competitive and other funds (19)：

2023 - 2026 Roles of cancer extracellular vesicles in hijacking macrophages and metastatic niche formation
2023 - 2026 Roles of cancer extracellular vesicles in hijacking macrophages and metastatic niche formation
2024 - 2025 抗炎症食品としてのSAC高含有ニンニク粉末の開発
2023 - 2025 Verification and Mechanism Elucidation of Blood-Brain Barrier Permeability of Food-Derived Functional Compounds Using Organ-on-a-Chip Systems
2021 - 2024 Next-generation mechanomedicine through the development of new mechanical load devices

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Papers (76)：

Hiroshi Yamada, Hirona Osaka, Nanami Tatsumi, Miu Araki, Tadashi Abe, Keiko Kaihara, Ken Takahashi, Eizo Takashima, Takayuki Uchihashi, Keiji Naruse, et al. Direct Binding of Synaptopodin 2-Like Protein to Alpha-Actinin Contributes to Actin Bundle Formation in Cardiomyocytes. Cells. 2024. 13. 16. 1373-1373
Yun Liu, Rumaisa Kamran, Xiaoxia Han, Mengxue Wang, Qiang Li, Daoyue Lai, Keiji Naruse, Ken Takahashi. Human heart-on-a-chip microphysiological system comprising endothelial cells, fibroblasts, and iPSC-derived cardiomyocytes. Scientific Reports. 2024. 14. 1. 18063-18063
Mengxue Wang, Yun Liu, Rumaisa Kamran, Xiaoxia Han, Keiji Naruse, Ken Takahashi. Reconstructing heart functions on a microfuidic chip. The Journal of Physiological Sciences. 2024. 74. Suppl 2. 231-231
Mengxue Wang, Harumi Idei, Chen Wang, Yin Liang, Yun Liu, Yusuke Matsuda, Ken Takahashi, Hiroshi Kamioka, Keiji Naruse. Effect of mechanical stretching stimulation on maturation of human iPS cell-derived cardiomyocytes co-cultured with human gingival fibroblasts. bioRxiv. 2023
Yun Liu, Rumaisa Kamran, Xiaoxia Han, Mengxue Wang, Qiang Li, Daoyue Lai, Keiji Naruse, Ken Takahashi. Development of a human heart-on-a-chip model using induced pluripotent stem cells, fibroblasts and endothelial cells. bioRxiv. 2023

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MISC (28)：

Chengyu Shi, Ken Takahashi. Recapitulation and Application of Cardiac Function on Heart-on-a-Chip. Circulation Control. 2024
Takahashi K, Sasanami M, Osada H, Naruse K. Cellular mechanism of gravity sensing. 2018. 69. 2. 106-109
Takahashi K, Oh H, Iribe G, Matsuura K, Naruse K. Application of mechanobiological engineering to regenerative and reproductive medicine. Trans JSMBE. 2017. 55. 4PM-Abstract. 340-340
Takahashi K, Naruse K. Response to mechanical stimulus and cardiovascular homeostasis. Clinical Calcium. 2016. 26. 12. 1671-1676
Takahashi K. Mechanosensor. Okayama Igakkai Zasshi (Journal of Okayama Medical Association). 2016. 128. 1. 61-62

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Patents (4)：

Method for producing cardiomyocytes
Centrifugal microscope
Cell incubator
Preventive/therapeutic reagent for ischemic heart diseases

Books (7)：

エネルギー代謝・生体エネルギー代謝
日本生体医工学会 2022
感覚受容器
日本生体医工学会 2022
Dynamic remodeling of the heart and blood vessels: implications of health and disease
Wiley-Blackwell 2016 ISBN:9781118966143
Innovation of vascular engineering by mechano-medicine
Springer Japan 2016 ISBN:9784431548
Guyton and Hall Textbook of Medical Physiology, 11th Edition
Elsevier Japan 2010 ISBN:9784860347246

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Lectures and oral presentations (107)：

Impact of Simulated Microgravity on Cellular Aging: Insights from AI Imaging
(2025)
Revolutionizing Physiology: Advances in Organ-on-a-Chip Technology
(2025)
Elucidation of the Microgravity-Induced Aging Acceleration Mechanism through AI-Assisted Cell Identification
(Hyper Interdisciplinary Conference 2024 OSAKA 2024)
ヒト臓器チップ技術の最前線
(湘南iPark サイエンスセミナー 2024)
Recapitulating heart function using organ chip technology
(The 45th Annual Meeting of Japan Society of Circulation Control in Medicine 2024)

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Works (8)：

中央西日本メディカル・イノベーション
高橋賢 2018 -
第13回国際バイオテクノロジー展/技術会議
高橋賢 2014 -
岡山メディカルイノベーション
高橋賢 2014 -
BIO tech 2014
2014 -
Bio Japan 2012 World Business Forum
2012 -

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Education (1)：

- 2006 Nagoya University Graduate School of Medicine

Professional career (1)：

Ph. D. (Medicine) (Nagoya University)

Work history (8)：

2023/06 - 現在 Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Associate Professor
2020 - 現在 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences Research Associate Professor
2010 - 2020 Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Assistant Professor
2018 - 2019 Harvard University Wyss Institute for Biologically Inspired Engineering Visiting Scholar
2007 - 2010 Nagoya University Graduate School of Medicine Assistant Professor

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Committee career (19)：

2023/04 - 現在 Japanese Society for Medical and Biological Engineering Representative
2022/12 - 現在 Okayama University Department of Medicine Molecular Pathogenesis Organizers
2022/08 - 現在日本病態生理学会評議員
2021/04 - 現在 Okayama University Department of Medicine Member, Curriculum Committee
2021/01 - 現在 The BME Society of Okayama Prefecture Secretary General

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Awards (13)：

2023/10 - Tsukuba Clinical Research & Development Organization (T-CReDO) Top Performing Team Research Studio 2023
2023/09 - The Osaka Chamber of Commerce and Industry, Kansai Innovation Initiative Finalist U-START UP KANSAI open pitch for university-based startups
2023/02 - New Energy and Industrial Technology Development Organization Finalist NEDO Technology Commercialization Program Final Examination
2023/02 - BIPROGY Inc. BIPROGY Award The 5th Okayama Tech Plan Grand Prix
2023/02 - OLBA HEALTHCARE HOLDINGS, Inc. OLBA Healthcare Prize The 5th Okayama Tech Plan Grand Prix

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Association Membership(s) (7)：

日本病態生理学会 , Japan Society of Aerospace and Environmental Medicine , Japanese Society for Medical and Biological Engineering , Physiological Society of Japan , The Biophysical Society of Japan , European Society of Cardiology , O-NECUS Interview Board

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