Kamada Shinji

カマダシンジ | Kamada Shinji

Affiliation and department：
Job title： Professor

Research field (1)： Tumor biology

Research keywords (3)： Senescence , cell cycle , apoptosis

Research theme for competitive and other funds (20)：

2021 - 2024 Establishment of a basis for the development of anti-aging medicine using spontaneous senescent cells
2020 - 2023 Basic research for the development of novel anticancer drugs targeting senescent cells induced by cancer treatment
2013 - 2016 Identification and characterization of cellular senescence-specific genes
2008 - 2010 Regulation mechanisms of mTOR-mediated nutrient signaling by protein phosphatase PP2A
2008 - 2009 細胞増殖制御におけるカスパーゼの役割

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Papers (33)：

Taiichi Osumi, Taiki Nagano, Tetsushi Iwasaki, Jotaro Nakanishi, Kazuyuki Miyazawa, Shinji Kamada. Lysine-specific demethylase 1 (LSD1) suppresses cellular senescence by riboflavin uptake-dependent demethylation activity. Scientific Reports. 2025. 15. 1
Ryoko Katasho, Taiki Nagano, Tetsushi Iwasaki, Shinji Kamada. Nectin-4 regulates cellular senescence-associated enlargement of cell size. Scientific Reports. 2023. 13. 1. 21602
Keitaro Nakagawa, Taiki Nagano, Ryoko Katasho, Tetsushi Iwasaki, Shinji Kamada. Integrin β1 transduces the signal for LY6D-induced macropinocytosis and mediates senescence-inducing stress-evoked vacuole formation via FAK. FEBS Letters. 2022. 596. 21. 2768-2780
Taiki Nagano, Yuto Awai, Shione Kuwaba, Taiichi Osumi, Kentaro Mio, Tetsushi Iwasaki, Shinji Kamada. Riboflavin transporter SLC52A1, a target of p53, suppresses cellular senescence by activating mitochondrial complex II. Molecular Biology of the Cell. 2021. 32:br10
Taiki Nagano, Tetsushi Iwasaki, Kengo Onishi, Yuto Awai, Anju Terachi, Shione Kuwaba, Shota Asano, Ryoko Katasho, Kiyoko Nagai, Akio Nakashima, et al. LY6D-induced macropinocytosis as a survival mechanism of senescent cells. Journal of Biological Chemistry. 2021. 296. 100049-100049

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MISC (5)：

長野太輝, 鎌田真司. 老化細胞の空胞形成を司る分子メカニズムと生理的意義. 基礎老化研究. 2022. 46. 1. 47-49
H. Kobayashi, T. Saito, K. Sato, T. Hosokawa, K. Tsutsumi, A. Asada, S. Kamada, T. Ohshima. The role of Tyr15 phosphorylation in Cdk5 activation. JOURNAL OF NEUROCHEMISTRY. 2012. 123. 114-114
小林弘侑, 斉藤太郎, 佐藤亘, 細川智永, 堤弘次, 浅田明子, 鎌田真司, 大島登志男, 久永眞市. Cdk5チロシン15のリン酸化はCdk5活性化サブユニットp35によって阻害され,Cdk5の活性化には関与しない. 日本生化学会大会(Web). 2012. 85th
KAMADA Shinji, KUSANO Hajime, FUJITA Hisakazu, OHTSU Makoto, KOYA Richard Chikara, KUZUMAKI Noboru, TSUJIMOTO Yoshihide. Functional analysis of caspase substrates on apoptosis. 1998. 21. 564-564
LEE Jeong-Hwa, KAMADA Shinji, TAKAHASHI Takeshi, YASUHARA Noriko, TSUJIMOTO Yoshihide. Molecular Cloning of bis gene encoding a novel Bcl-2 binding protein. 1998. 21. 569-569

Books (11)：

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Lectures and oral presentations (98)：

Senescence-related gene EPN3 induces DNA damage via extracellular vesicles
(2024)
TPAによる転移性メラノーマ増殖抑制におけるTC-TP/PTPN2及びSH-PTP2/PTPN11の機能解析
(第47回日本分子生物学会 2024 2024)
リジン特異的脱メチル化酵素LSD1の活性化を介した細胞老化抑制機構の解析
(第47回日本分子生物学会2024 2024)
自発老化細胞の形成機構とSASPを介した周辺がん細胞への影響
(第47回日本分子生物学会2024 2024)
細胞老化抑制機構における脱メチル化酵素JMJD2Cの機能解析
(第47回日本分子生物学会2024 2024)

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Education (1)：

Professional career (2)：

Association Membership(s) (3)：

日本基礎老化学会 , 日本癌学会 , 日本分子生物学会

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