Sobue Kazuya

2022 - 2025 Brain hypothermia focusing on erythropoietin and microglial activation control

2022 - 2025 海馬歯状回における神経細胞の新生低下に注目した慢性疼痛の発症機序解明

2022 - 2025 アストロサイトの活性化に着目した三叉神経障害性疼痛の発生機序の解明

2022 - 2025 Influence of peripheral schwann cells on neuropathic pain

2021 - 2025 血液脳関門の破綻に着目した術後神経認知機能障害の発症機序解明

2020 - 2023 大規模脳活動記録とイメージングによる痛み認知の脳内情報伝達回路の解明

2021 - 2023 活性化脊髄後角アストロサイトのL-乳酸輸送異常による神経障害性疼痛の機序解明

2019 - 2022 Creation and clinical application of an EEG model to identify pain-specific patterns from large-scale electrophysiological recordings

2018 - 2021 Elucidation of the effects of impaired glucose tolerance in the brain on postoperative cognitive dysfunction and establishment of its preventive methods

2018 - 2021 Elucidation of the Pathogenesis of Chronic Pain Focusing on Decreased Neuronal Generation in the Hippocampus.

2018 - 2021 Elucidation of the mechanism of chronic pain development focusing on prefrontal cortex function and its application to treatment

2017 - 2020 Preventing brain edema involved with astrocyte expansion due to its potassium intake

2017 - 2020 Basic research and clinical application of the protective effect of whey peptide on drug-induced liver injury.

2017 - 2020 Elucidation of pathogenic mechanism of postoperative cognitive dysfunction in cancer patients and establishment of prevention method

2016 - 2019 The Verification of Effectiveness of Postanesthesia Care Units by the Registry of Postoperative Serious Adverse Events

2016 - 2019 Analysis of the involvement of Acid-sensing ion channels in post-operative pain enhancement in diabetic patients

2016 - 2019 Elucidation of the pathogenesis of postoperative cognitive dysfunction in diabetic patients and establishment of a preventive method

2016 - 2019 Elucidation of the mechanism of neuroprotective effect of erythropoietin through microglia and basic research on drug development

2016 - 2019 Development of effective curative for chronic pain based on the separation of sensory-discriminative and affective-motivational components of pain recognition in animal and human.

2015 - 2018 Establishment of safe anesthesia methods for dementia patients

2014 - 2017 Development of ventilator-associated lung injury prevention method focused on antioxidant action.

2014 - 2017 Elucidation of the mechanism of central nervous system disorder caused by severe infections focused on water channel and development of novel therapeutic methods.

2013 - 2016 Analysis of a new water channel function in the brain edema formation and development of new treatment for brain edema

2013 - 2016 Elucidation of the pathogenesis of brain white matter injury caused by perioperative hypoxic ischemia and the development of regeneration therapy

2012 - 2015 A study searching for pain-associated biomarkers

2012 - 2015 Protective effect of hypercapnia for ventilator induced lung injury and develop a new drug for ventilator induced lung injury.

2012 - 2015 Safety anesthesia management for Alzheimer's disease

2012 - 2015 Practical use with control of aquaporin for brain edema decrease using knockdown technique

2011 - 2013 The role of ASICs in neuroprotection after spinal ischemia

2010 - 2012 Elucidation of the occurrence and development of the treatment for the failure to central nerve system accompanied by severe infection

2010 - 2012 Functional analysis of water channel in ischemic brain injury after cardiac arrest

2009 - 2011 Functional analysis of water channel for mild hypothermia-induced brain edema decrease using knockdown technique

2009 - 2011 Function of a new aquaporin in the brain edema.

2009 - 2011 Evaluation of neuroendocrine in primary afferent neuron of neuropathic pain

2006 - 2008 Aquaporin as a target of a new therapy for brain edema

2006 - 2008 analysis of water channel function to decrease of brain edema caused by mild hypothermia with using RNAi technique

2005 - 2007 血管内皮前駆細胞移植による脳毛細血管再生と遺伝子治療への応用

2003 - 2005 Regulation mechanisms of aquaporin in the brain and its functions in the brain edema

2003 - 2005 脳における水チャネル(アクアポリン)の機能と発現調節機構

2001 - 2003 Expression of the Water Channel in the Central Nervous System and Mechanisms of the Regulation of the Expression