Research theme for competitive and other funds (5)：
2015 - 2018 Structure basis of lipophilic ligand binding of membrane protein involving in lipid mediator biosynthesis
2011 - 2013 Crystal structure determination of microsomal prostaglandin E2 synthase 1 with the open active site.
2008 - 2010 X-ray crystallographic analysis of microsomal prostaglandin E2synthase1
2005 - 2006 Structural basis of the neutral sphingomyelinase to understand the lipid raft
脂質関連蛋白質の構造生物学研究
Papers (64)：
Marin Yokomine, Jumpei Morimoto, Yasuhiro Fukuda, Takumi Ueda, Koh Takeuchi, Koji Umezawa, Hideo Ago, Hiroaki Matsuura, Go Ueno, Akinobu Senoo, et al. A high-resolution structural characterization and physicochemical study of how a peptoid binds to an oncoprotein MDM2. Chemical Science. 2024. 15. 19. 7051-7060
Ryoko Ando, Satoshi Shimozono, Hideo Ago, Masatoshi Takagi, Mayu Sugiyama, Hiroshi Kurokawa, Masahiko Hirano, Yusuke Niino, Go Ueno, Fumiyoshi Ishidate, et al. StayGold variants for molecular fusion and membrane-targeting applications. Nature Methods. 2023
Hanna Kwon, Jaswir Basran, Chinar Pathak, Mahdi Hussain, Samuel L Freeman, Alistair J Fielding, Anna J Bailey, Natalia Stefanou, Hazel A Sparkes, Takehiko Tosha, et al. XFEL Crystal Structures of Peroxidase Compound II. Angewandte Chemie International Edition. 2021
Samuel L Rose, Svetlana V Antonyuk, Daisuke Sasaki, Keitaro Yamashita, Kunio Hirata, Go Ueno, Hideo Ago, Robert R Eady, Takehiko Tosha, Masaki Yamamoto, et al. An unprecedented insight into the catalytic mechanism of copper nitrite reductase from atomic-resolution and damage-free structures. Science advances. 2021. 7. 1
Suga M, Akita F, Yamashita K, Nakajima Y, Ueno G, Li H, Yamane T, Hirata K, Umena Y, Yonekura S, et al. An oxyl/oxo mechanism for oxygen-oxygen coupling in PSII revealed by an x-ray free-electron laser. Science (New York, N.Y.). 2019. 366. 6463. 334-338
OHNISHI Yusuke, TANAKA Hideaki, OKUMURA Hideo, BABA Kiyoki, KAWANO Yoshiaki, KUMASAKA Takashi, TESHIMA Kezo, IKEGAMI Takahisa, IKEGAMI Takahisa, AGO Hideo, et al. Redox dependent conformational change of the [2Fe-2S] ferredoxin revealed by ultrahigh resolution X-ray crystallography. 日本化学会春季年会講演予稿集(CD-ROM). 2020. 100th
Yasufumi Umena, Keisuke Kawakami, Nobuo Kamiya, Yoshiaki Kawano, Keitaro Yamashita, Hideo Ago, Masaki Yamamoto, Jian-Ren Shen. Crystallographic study on estimation of the valence of each of the four Mn atoms in Photosystem II using anomalous diffraction techniques. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2019. 75. A363-A363
M. Kubo, A. Shimada, S. Baba, K. Yamashita, K. Hirata, M. Yamamoto, K. Shinzawa-Itoh, H. Ago, S. Yoshikawa, T. Tsukihara. Observation of water-channel opening of cytochrome c oxidase by time-resolved XFEL crystallography. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2017. 46. S149-S149
Native structure analysis of large metalloproteins using femtosecond crystallography.
(Science@FEL 2016)
Development of a method of femtosecond crystallography enabling determination of high-resolution native structure of huge proteins.
(2015)
High-resolution native structure analyses of supramacromolecular complexes susceptible to radiation damage.
(29th European Crystallographic Meeting 2015)
High-Resolution Native Structure Determination of Photosystem II by Serial Femtosecond Rotation Crystallography at SACLA.
(Gordon Research Conference: X-ray Science 2015)
