Ogawa Yoshihiro

2020 - 2022 What is the functionality and nonfunctionality of endocrine tumors?

2020 - 2022 NASHの発症・進展における炎症細胞社会の時空間的変化の解明

2019 - 2022 Development and progression mechanism of NASH from the viewpoint of cell-cell interaction and medical application

2018 - 2020 炎症細胞社会に焦点を当てた閉経後NASH肝癌の発症機構の解明と予防戦略の開発

2017 - 2019 Molecular mechanism of adipose tissue healthy expansion and its medical application

2016 - 2019 Molecular mechanism of DNA methylation-mediated epigenome memory and its functional implications

2016 - 2019 Elucidation of molecular mehcanisms of autoimmune pancreatitis

2016 - 2019 Epigenetic regulation of inflammatory response by environmental stress.

2016 - 2018 ω-3多価不飽和脂肪酸のDNAメチル化制御作用と機能的意義の解明

2015 - 2018 Developmental Origins of Hepatic Steatosis; A Possible Involvement of Endoplasmic Reticulum Stress Response

2015 - 2018 Molecular mechanism of adipose tissue inflammation through Mincle and cell-cell interactions

2015 - 2017 Posttranslational modification-dependent FoxO1 target genes in endothelial cells and its medical application

2014 - 2017 Analysis of epigenetic memory of FGF21 gene in the liver

2014 - 2017 Epigenetic analysis of gene expression in central nervous system of offspring derived from dam with hypothyroxinemia during pregnancy

2012 - 2015 Rapid catch-up growth subsequent to undernourishment in utero and metabolic syndrome in later life

2013 - 2014 Molecular mechanism of tissue fibrosis and develpment of revolutionary anti-fibrotic therapy

2011 - 2014 Molecular Mechanism of Metabolic Memory via a DNA Methylation and Its Medical Application

2009 - 2014 Homeostatic inflammation: Molecular basis and dysregulation

2009 - 2014 Functional role of pathogen sensors and their endogenous ligands in the metabolic syndrome

2011 - 2013 Clinical evidence-based investigation of developmental mechanism in diabetic retinopathy

2012 - 2012 Concept of Physiologic Inflammation and Its Functional Significance

2011 - 2011 Identification of target genes for DNA methylation in skeletal muscle and its medical application

2010 - 2011 Establishment of the evaluation of early development of atherosclerosis in obesity and metabolic syndrome-focus on the fraction of fatty acid and function of monocytes-

2009 - 2011 Study of organ crosstalk associated with adipose tissue in the fetal origins of adult disease

2009 - 2011 Establishment of biomarker panel for the early detection of atherosclerosis and the prevention of the cardio-renal syndromes in obesity and metabolic syndrome-role of the phenotypes and the function of peripheral blood monocytes-

2010 - 2010 新生児期の栄養環境のエピゲノム記憶と成人期における疾患感受性の分子機構の解明

2008 - 2010 Molecular mechanism of adipose tissue remodeling and lipotoxicity

2008 - 2009 肥満に関連するDNAメチル化標的遺伝子の同定と機能解析

2007 - 2008 中枢神経系を介した臓器間クロストークによる腎障害進展の分子機構の解明

2006 - 2007 Anti-inflammatory effects of anti-insulin resistant drugs and monocyte functional analysis in visceral obesity

2003 - 2007 Molecular medicine of adipocyte differentiation

2006 - 2006 メタボリックシンドローム発症における胎生期栄養環境の関与の研究と予防戦略の開発

2006 - 2006 子宮内胎仔発育遅延マウスの脂肪組織の変化と生活習慣病易感受性に関する研究

2005 - 2006 Pathophysiologic and therapeutic implication of leptin as a pro-inflammatory cytokine

2004 - 2005 The Association of Fetal Malnutrition with Metabolic Syndrome in Adulthood

2004 - 2004 脂肪細胞の増殖・分化における血管新生の意義:脂肪細胞に由来するVEGFに着目して

2003 - 2004 Molecular Medicine of Leptin Regulation of Energy Metabolism and Its Medical Application

2003 - 2004 An Experimental and Clinical Study of the Role of Intrauterine Undernutrition in the Development of Adult Diseases

2000 - 2004 遺伝子変異動物を用いたナトリウム利尿ペプチド系の虚血再灌流傷害における意義の解明

2003 - 2003 未分化間葉景幹細胞を用いた脂肪細胞分化の分子機構の解明と医学応用

2002 - 2003 C-type Natriuretic Peptide Prevents Cardiac Remodeling after Myocardial Infarction.

2002 - 2003 胎盤由来物質による母体エネルギー代謝調節および胎児への糖供給調節機構の解析

2001 - 2003 Molecular Basis of Centrally-controled Energy Homeostasis -Focusing on Leptin Resistance-

2001 - 2003 Suppressive autoantibodies in rheumatoid arthritis : construction of gene-modified animals and analysis of their arthrapathy

2002 - 2002 発生工学的手法を用いた前駆脂胞細胞の単離同定の試み

2001 - 2002 New Therapeutic Approach for Congestive Heart Failure and Ischemia - reperfusion Injury Based on Cytokine Resistance

2001 - 2002 Molecular mechanism of leptin-induced increase in glucose and lipid metabolism

2001 - 2002 A comprehensive study on the pathophysiology of fetal growth restriction based on the cell biological analysis of development of placental vascular system

2001 - 2002 Molecular mechanism of BDNF as a agent that circumvents leptin resistance

2001 - 2002 A Study on the metabolism and action of thyroid hormones in the bone and cartilage.

1998 - 2002 Molecular Study on Physiological and Clinical Significance of Adrenomedullin

2001 - 2001 脂肪細胞増殖・分化調節因子としてのFGF10の生理的・病態生理的意義に関する研究

2000 - 2001 Elucidation of molecular mechanism of leptin resistance, using transgenic mice over-expressing leptin

2000 - 2001 ELUCIDATION OF SIGNIFICANCE OF UCP3 IN DIABETES AND OBESITY USING TRANSGENIC MICE

2000 - 2000 cGMP系関連遺伝子多型に基づいた循環器疾患遺伝的要因の解明とその医療への応用

1999 - 2000 Elucidation of Molecuolar Mechanism for Cardioprotection-Study from Genetic Engineered Mice

1999 - 2000 Physiologic and pathophysiologic role of C-type natriuretic peptide

1999 - 2000 A comprehensive study on the role of the obese gene product, leptin in reproduction and fetal development

1999 - 2000 follistatin-related protein : analysis of arthritis induced in its transgenic mice

1999 - 2000 Molecular Mechanism for Coronary Spastic Angina as a Transcriptional Factor-Related Disease

1999 - 2000 Multi-center research on molecular mechanism of cardiovascular remodeling using genetically-engineered animals

1998 - 2000 Clinical implication of cardiovascular hormones

1998 - 1998 新しい胎盤由来ホルモンとしてのレプチンの臨床的意義と分子機構の解明

1997 - 1998 New Animal Models Of Leaness And Obesity by Genetic Engineering and its Application to Therapy

1997 - 1998 Molecular Medicine of Clinical Implication of Obese Gene Product

1997 - 1998 Transcriptional regulation of leptin in adipocytes.

1997 - 1997 冠攣縮性狭心症病因遺伝子としての内皮型NO合成酵素遺伝子異常の分子生物学的解析

1997 - 1997 新しい骨代謝調節因子としてのナトリウム利尿ペプチドファミリーの分子機構の解明

1994 - 1996 腎臓における新しい細胞間情報伝達蛋白質のクローニング-シグナルシークエンストラップ法を用いて-

メタボリックシンドロームの成因の解明と治療戦略の開発に関する分子医学的研究

Molecular medicine of the metabolic syndrome