2022 - 2025 Elucidation of age-associated alterations in hematopoietic stem cell niches
2023 - 2024 免疫環境による造血制御機構の解明
2022 - 2024 Elucidation of the paradox in stem cell competition during aging of hematopoietic system
2022 - 2023 造血-免疫連関における栄養環境変化の役割
2022 - 2023 先進的な健康長寿延伸医療の開発を目指した老化メカニズムの解明
2021 - 2023 遺伝子異常に依存した食餌性ストレスによる白血病進展機構の解析
2019 - 2022 栄養環境変化による造血幹細胞恒常性維持機構の解明
2020 - 2021 食餌性ストレスによるFLT3-ITD変異陽性白血病の悪性進展機構の解析
2018 - 2020 骨髄増殖性腫瘍の環境因子依存的発症機構の解析
2019 - 2020 アクチン重合調節による造血幹細胞の自己複製能制御技術の開発
2015 - 2019 A study of microenvironment for maintenance or acquisition of malignant property
2018 - 2019 食餌性ストレスに対する造血幹細胞の防御機構
2016 - 2019 アクチン重合調節を介した造血幹細胞の自己複製制御機構の解析
2013 - 2016 カロリー制限による造血幹細胞動態制御の分子基盤の解析
2013 - 2014 細胞競合を介した幹細胞クローン増幅機構の解明
2011 - 2013 Regulations of hematopoietic stem cell system by the control ofintracellular ATP
2011 - 2012 造血幹細胞の運命決定を支配する微小環境(ニッチ)制御メカニズムの解明
2009 - 2011 Analysis of hematopoietic stem cell and leukemic stem cell niche by focusing on Spred-1 functions
2007 - 2009 Analysis of functions of Spred-1 in melanocyte stem cells and common molecular mechanisms in tissue-specific stem cell regulations.
2007 - 2008 色素幹細胞の維持・分化を制御する幹細胞ニッチ分子の同定とその仕組みの解明
2007 - 2007 色素幹細胞の質的変化に着目した白髪の発症機序の解明
2003 - 2004 哺乳類雄性生殖幹細胞系をモデルとした組織幹細胞の維持・増殖・分化機構の解析
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Papers (39):
Masaya Ueno, Hiroki Sugiyama, Feng Li, Tatsuya Nishimura, Hiroshi Arakawa, Xi Chen, Xiaoxiao Cheng, Shinji Takeuchi, Yumie Takeshita, Toshinari Takamura, et al. A Supramolecular Biosensor for Rapid and High-Throughput Quantification of a Disease-Associated Niacin Metabolite. Analytical Chemistry. 2024. 96. 36. 14499-14507
Kenta Kurayoshi, Yusuke Takase, Masaya Ueno, Kumiko Ohta, Kyoko Fuse, Shuji Ikeda, Takayoshi Watanabe, Yuki Nishida, Shin-Ichi Horike, Kazuyoshi Hosomichi, et al. Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation. Cell death & disease. 2023. 14. 9. 642-642
Loc Thi Pham, Hui Peng, Masaya Ueno, Susumu Kohno, Atuso Kasada, Kazuyoshi Hosomichi, Takehiro Sato, Kenta Kurayoshi, Masahiko Kobayashi, Yuko Tadokoro, et al. RHEB is a potential therapeutic target in T cell acute lymphoblastic leukemia. Biochemical and Biophysical Research Communications. 2022. 621. 74-79
Yongwei Jing, Masahiko Kobayashi, Ha Thi Vu, Atsuko Kasahara, Xi Chen, Loc Thi Pham, Kenta Kurayoshi, Yuko Tadokoro, Masaya Ueno, Tomoki Todo, et al. Therapeutic advantage of targeting lysosomal membrane integrity supported by lysophagy in malignant glioma. Cancer science. 2022. 113. 8. 2716-2726
Yuko Tadokoro, Atsushi Hirao. The Role of Nutrients in Maintaining Hematopoietic Stem Cells and Healthy Hematopoiesis for Life. International Journal of Molecular Sciences. 2022. 23. 3. 1574-1574