Fujiwara Toshiyoshi

2019 - 2022 Development of boron neutron capture therapy targeting gastrointestinal cancer and search for biomarkers of its efficacy

2019 - 2022 Practical classification of molecular subtype of intrahepatic cholangiocarcinoma including liquid biopsy

2016 - 2019 Development of the Dual fluorescent cytology with tumor-specific viruses for gastrointestinal cancer precision medicine

2016 - 2019 Detection of Circulating MicroRNAs with Ago2 Complexes to Monitor the Tumor Dynamics of Colorectal Liver Metastasis Patients during Chemotherapy

2015 - 2018 Preclinical analysis of oncolytic adenovirus infection to patient-derived tumor specimens of bone and soft tissue tumors

2015 - 2018 Development of novel treatment strategy against bone and soft tissue sarcoma by combination of tumor-specific oncolytic adenovirus and radiotherapy

2015 - 2018 Development of oncolytic virotherapy against both cancer cells and cancer-associated fibroblasts

2015 - 2017 Analysis for intraperitoneal cancer microenvironment to elucidate the biological mechanism of peritoneal metastasis of gastrointestinal cancer

2014 - 2016 Novel targeting therapy to cancer-associated fibroblasts for treatment-resistant carcinomas

2013 - 2016 "Cell-in-cell" activity-based tumor-specific delivery of biologics

2013 - 2016 p53-expressing oncolytic adenovirus enhances the anti-tumor effect of chemotherapy and radiotherapy

2013 - 2016 Therapeutic potential of circulating tumor microenvironment based on metastatic mechanism

2013 - 2016 Photoimmunotherapy for gastrointestinal cancer

2013 - 2016 Novel treatment strategy for colorectal cancer based on genetic/ epigenetic information

2013 - 2015 Fluorescent virus-guided capturing of epithelial-mesenchymal transition (EMT)-induced circulating tumor cells (CTCs) for genetic analysis

2012 - 2015 Establishment of 4th generation of islet isolation and the clinical application

2011 - 2015 Development of an efficient gene expression vector utilizing RNA-binding proteins and antisense transcripts

2011 - 2014 Establishment of non-invasive cancer screening paradigm

2011 - 2013 Fluorescence-guided detection and genetic analysis of circulating tumor cells

2011 - 2013 Tumor suppressor FHIT regulates tumor invasion of pancreatic cancer cells via inhibiting association of Ezrin and Actin cytoskeleton

2011 - 2012 Circulating Tumor Cell of Gastrointestinal Stromal Tumor

2010 - 2012 Molecular therapy for gastric cancer using HER2-extracellular domain-expressing adenovirus

2010 - 2012 Circulating tumor cell-based tailor-made therapy for hepatocellular carcinoma

2010 - 2012 Development of new diagnostic methods for bladder cancer using GFP expressing adenovirus vector

2008 - 2010 Development of an adenovirus vector containing microRNA-regulated gene expression system

2008 - 2009 進行食道癌に対するテロメラーゼ活性を標的とする新規アデノウイルス製剤の創薬研究

2007 - 2008 Telomerase-specific virotherapy for malignant mesothelioma

2007 - 2008 Telomerase specific oncolytic virotherapy to purge lymph node metastasis for minimizing invasiveness of gastrointestinal surgery

2006 - 2008 The development study of the new gene therapy that assumed telomerase activity for urinary cancers.

2005 - 2006 Telomerase-specific fluorescent navigation system for lung cancer surgery

2005 - 2006 Development of immortalized allogenic dendritic cells expressing telomerase for treatment of gastroenterological cancer

2004 - 2005 Development of cell therapies using reversibly immortalized human pancreatic beta cell lines

2003 - 2005 DEVELOPMENT OF TAILORED-MADE TYPE PROSTATE CANCER GENE THERAPY AIMING AT SYSTEMIC IMMUNE-ACTIVATION

2003 - 2004 Molecular Fluorescent Imaging of Metastatic Tumors with Conditionally Replication-Selective Adenovirus and GFP Gene

2003 - 2003 テロメラーゼ活性を標的とした新規ウイルス療法の開発と化学療法との相互作用の解明

2001 - 2002 Molecular Analysis of Resistance to p53 Gene Therapy in Human Lung Cancer

2001 - 2001 臨床応用可能なウイルスベクター製造のための企画調査

1999 - 2000 Development of Gene Therapy for Lung Cancer using a Novel Antiangiogenic Factor BAI1

1997 - 1998 Development of Differentiation-directed Cancer Gene Therapy with p21

1996 - 1997 Basic and Clinical Research of p53 Gene Therapy for Human Cancer

1995 - 1996 Gene Therapy for Colon Cancer with Adenoviral Vector Expressing Tumor Suppressor p53 Gene