Rchr

J-GLOBAL ID：200901021917424212 Update date: Jul. 20, 2024

Hosoyamada Makoto

ホソヤマダマコト | Hosoyamada Makoto

Affiliation and department：
Job title： Professor

Research field (3)： Nephrology , Pharmacology , Clinical pharmacy

Research keywords (6)：病態生理 , 尿酸 , 腎臓 , pathophysiology , urate , kidney

Research theme for competitive and other funds (38)：

2022 - 2025 Elucidation of the mechanism of exercise-induced acute kidney injury associated with renal hypouricemia type 1 model mice
2018 - 2022 Sutudy for substances responsible for renal failure death in xanthine oxidoreductase knockout mice
2017 - 2020 Generation of human urate metabolism complete model mice by suppressing xanthine dehydrogenase expression
2014 - 2017 Analysis of genes influencing serum urate levels
2014 - 2017 Studies on androgenic and angiotensin system inhibitors for inhibiting the progression of chronic kidney disease

2013 - 2016 Development of a novel experimental evaluation method for predicting the drug delivery to the brain in human

2014 - 2016 Elucidation of environmental factors involved in the onset of hyperuricemia using complete model animals of human uric acid metabolism

2011 - 2013 Identification and analysis of genes influencing serum uric acid levels

2011 - 2013 Elucidation of the pathogenic mechanism of hyperuricemia in obesity and metabolic syndrome

2008 - 2010 Elucidation of mechanism for exercise-induced acute renal failure in urate transporter deficient mice

2008 - 2010 Production of disease model mice for the drug screening of familial juvenile hyperuricemic nephropathy

2005 - 2007 Genetic analysis for uric acid handling in the kidney

2005 - 2007 Analysis of the mechanism of cadmium nephropathy based on, cadmium kinetics

2005 - 2007 Analysis of the onset mechanism of acute renal failure post exercise using urate transporter knockout mice

2003 - 2004 Study of drug transport mechanism by renal organicion transporters and their clinical significance

2002 - 2004 Genetic analysis for mechanism of underexcretion type hyperuricemia

2002 - 2004 Protein analysis of steroid resistant congenital nephrotic syndrome gene: podocin

2002 - 2004 Development of novel anti-uricosuric agents based on the genomic strategy.

2001 - 2004 Genetic Abnormality of Renal Proximal Tubule-Specific Transporters as Causes of Sudden Death Syndrome in South-Eastern Asia

2001 - 2002 ヒト有機アニオントランスポーターhOAT1におけるプロモーター解析

2000 - 2002 Identification of transporter genes regulating systemic kinetics of drugs and foreign compounds and their genetic polymorphism

1999 - 2001 Molecular mechanisms of drug transport across cell membrane

1999 - 2001 FUNCTIONAL ANALYSIS OF THE ANIONIC DRUG TRANSPORTERS USING KNOCKOUT MICE

1999 - 2001 Cloning of transporters for anionic drugs and the application to pharmacokinetic analysis

1999 - 2000 ヒト尿酸トフンスポーター遺伝子のクローニングと機能解析

1998 - 2000 Development of artificial kidney hybridized with human organic anion transporter expressed cells

1998 - 1999 鼻粘膜薬物吸収におけるトランスポーターの役割に関する研究

1998 - 1999 ISOLATION AND ANALYSIS OF URATE TRANSPORTER OF HUMAN PROXIMAL TUBULE

1997 - 1999 Molecular cloning and functional expression of kidney-specific organic anionic drug transporters

1997 - 1998 New roprorective roles of amino acid transporrers

1997 - 1998 腎特異性グルタミン酸トランスポーターの遺伝子クローニングと機能特性

1996 - 1998 The study toward the development of specific agonist and antagonist for the purinergic receptors in the kidney

1997 - 1997 有機アニオン輸送の細胞内分子機序

1995 - 1997 腎毒性予測法の開発

1997 - 腎での尿酸輸送

1997 - Renal urate handling

1987 - 蛋白尿の病態生理

1987 - Pathophysiology of proteinuria

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Papers (120)：

Masaru Doshi, Yujin Natori, Akira Ishii, Daisuke Saigusa, Shiro Watanabe, Makoto Hosoyamada, Yutaka Hirashima-Akae. Hypothermia increases adenosine monophosphate and xanthosine monophosphate levels in the mouse hippocampus, preventing their reduction by global cerebral ischemia. Scientific reports. 2024. 14. 1. 3187-3187
藤井航, 浅川信一郎, 山崎修, 田村好古, 藤垣嘉秀, 細山田真, 柴田茂. リン酸化によるURAT1の制御機構の解明とメタボリックシンドロームに合併する尿酸代謝異常への関与の検討. 日本痛風・尿酸核酸学会総会プログラム・抄録集. 2024. 57回. 62-62
Yu Toyoda, Hiroshi Miyata, Naohiro Uchida, Keito Morimoto, Ryuichiro Shigesawa, Hidetoshi Kassai, Kazuki Nakao, Naoko H Tomioka, Hirotaka Matsuo, Kimiyoshi Ichida, et al. Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations. Pflugers Archiv : European journal of physiology. 2023
Hisayo Yamaoka, Keiko Yamaoka, Shigekazu Watanabe, Hideyuki Tanaka, Makoto Hosoyamada, Yuzo Komuro. Lactose Stabilization Prolongs In Vivo Retention of Cross-linked Fish Collagen Subcutaneous Grafts in Nude Mice. Plastic and reconstructive surgery. Global open. 2022. 10. 10. e4601
道志勝, 渡辺志朗, 名取雄人, 細山田真, 赤江豊. 甲状腺ホルモン投与がマウス脳虚血再灌流後の海馬TGF-β1遺伝子発現に及ぼす影響. 日本薬学会年会要旨集. 2022. 142年会. 28PO8-12

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MISC (409)：

道志勝, 名取雄人, 石井晃, 三枝大輔, 渡辺志朗, 細山田真, 赤江豊. Effect of hypothermia on the changes in the levels of metabolites in the mouse hippocampus caused by cerebral ischemia. 日本薬学会年会要旨集(Web). 2024. 144th
道志勝, 名取雄人, 石井晃, 渡辺志朗, 細山田真, 赤江豊. Metabolome analysis of hippocampus and serum in mouse model of cerebral ischmeia. 日本薬学会年会要旨集(Web). 2023. 143rd
河野肇, 木村佳貴, 津久井大輔, 細山田真. 痛風・高尿酸血症の病態動脈硬化における尿酸のインフラマソーム活性化を介した役割. 痛風と尿酸・核酸. 2021. 45. 1. 94-94
河野肇, 木村佳貴, 津久井大輔, 細山田真. 痛風・高尿酸血症の病態動脈硬化における尿酸のインフラマソーム活性化を介した役割. 日本痛風・尿酸核酸学会総会プログラム・抄録集. 2021. 54回. 44-44
道志勝, 渡辺志朗, 名取雄人, 細山田真, 赤江豊. Triiodothyronine aggravates delayed neuronal death caused by transient cerebral ischemia in mice. 日本薬学会年会要旨集(Web). 2021. 141st

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Patents (2)：

Books (2)：

薬学生のための新臨床医学-症候および疾患とその治療
広川書店 2009 ISBN:4567497902
Potassium-Retaining Diuretics : Aldosteron antagonists. In Diuretics : Handbook of Experimental Pharmacology. (共著)
Greger RF. Knauf H. Mutschler E. Springer 1995

Education (2)：

1992 - 1996 The University of Tokyo Post-graduate School of Medicine
- 1990 The University of Tokyo Faculty of Medicine School of Medicine

Professional career (1)：

PhD. (The University of Tokyo)

Work history (6)：

2011 - 現在 Teikyo University Faculty of Pharma-Science Professor
2008 - 2011 Keio University Faculty of Pharmacy Associate Professor
2007 - 2008 Kyoritsu University of Pharmacy Associate Professor
2005 - 2007 Kyoritsu University of Pharmacy Associate Professor
2001 - 2005 Kyorin University Faculty of Medicine Lecturer

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Committee career (2)：

2002 - 2005 The Japanese Pharmacological Society councilman
2003 - Japanese Society of Gout and Nucleic Acid metabolism councilman

Awards (1)：

2017/02 - 日本痛風·核酸代謝学会日本痛風・核酸代謝学会賞

Association Membership(s) (8)：

THE JAPANESE SOCIETY OF INTERNAL MEDICINE , THE PHARMACEUTICAL SOCIETY OF JAPAN , 日本痛風・核酸代謝学会 , 日本薬理学会 , 日本腎臓学会 , The Japanese Society of Nephrology , Japanese Society of Gout and Nucleic Acid metabolism , The Japanese Pharmacological Society

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