Research field (5)：
Hygiene and public health (non-laboratory)
, Hygiene and public health (laboratory)
, Healthcare management, medical sociology
, Pathobiochemistry
, Pharmacology
Research keywords (1)：
00
Research theme for competitive and other funds (43)：
2021 - 2026 ヘビの防御物質ブファジエノライド:食性進化のメカニズム解明
2019 - 2024 Tailor-maid cancer prevention towards the era of preemptive medicine.
2019 - 2023 Preventive strategy against arsenic carcinogenesis by TRAIL pathway activation and RB activation
2017 - 2022 Research of molecular-targeting prevention against inflammatory diseases using chemical biology.
2019 - 2021 Basic research for prevention of arteriosclerosis by cancer preventive ingredients with RB activation ability
2018 - 2020 A new colorectal cancer chemoprevention method to reduce side effects of aspirin
2015 - 2019 Application of molecular-targeting cancer prevention to human intervention study.
2016 - 2017 Molecular-targeting prevention against human papilloma virus-positive cervical cancer
2015 - 2016 Elucidation of the novel mechanisms of carcinogenesis induced by the cigarette and development of cancer prevention for carcinogenesis by sidestream smoke
2013 - 2016 Novel combination-oriented molecular-targeting therapy for keloid
2011 - 2012 Novel molecular-targeting prevention of cancer by sensitizing the effect of sodium butyrate
2009 - 2012 Development of micrRNA-targeting cancer prevention
2009 - 2010 GADD45を標的とした新規癌予防エピジェネティクス
2008 - 2009 TRAILとDR5を標的とした癌の「分子標的併用療法」の開発
2007 - 2008 エピジェネティックに失活した癌抑制遺伝子を標的とした新規癌予防法の開発
2005 - 2008 Research on a selection reference of chemopreventive agents for cancer and a development of tailor-made medicine for cancer prevention
1993 - 1995 Detection of novel molecules that regulates RB expression by screening random peptide library
1994 - 1994 網膜芽細胞腫遺伝子プロモーター領域における調節機構
1992 - 1994 網膜芽細胞腫の家系分析における新手法の開発
1992 - 1994 公衆衛生学的に有用な新しい癌体質診断法の開発
1993 - 1993 網膜芽細胞腫遺伝子プロモーター領域における調節機構
1988 - 1989 Development of serological diagnosis of pancreatic cancer for mass screening
癌の「遺伝子調節化学療法」
癌の分子予防医学
“Gene-regulating chemotherapy" of cancer
Molecular preventive medicine of cancer
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Papers (231)：
Yukihiro Itoh, Peng Zhan, Toshifumi Tojo, Pattaporn Jaikhan, Yosuke Ota, Miki Suzuki, Ying Li, Zi Hui, Yukiko Moriyama, Yuri Takada, et al. Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation. Journal of medicinal chemistry. 2023
片山 勇輝, 山田 忠明, 谷村 恵子, 森本 健司, 矢野 聖二, 堀中 真野, 酒井 敏行, 高山 浩一. RET変異がんにおけるHER3活性化を介したセルペルカチニブに対する治療抵抗性に関する基礎的検討(Intrinsic resistance to selpercatinib via HER3 signaling in RET aberrant cancercells). 日本癌学会総会記事. 2023. 82回. 115-115
Yukie Nohara, Keiko Taniguchi, Hiromi Ii, Shun Masuda, Hiroko Kawakami, Masakatsu Matsumoto, Yasunao Hattori, Susumu Kageyama, Toshiyuki Sakai, Susumu Nakata, et al. Development of an activity-based chemiluminogenic probe for γ-glutamylcyclotransferase. Organic & biomolecular chemistry. 2023
齋藤 友充子, 谷口 恵香, 飯居 宏美, 堀中 真野, 影山 進, 中田 晋, 浮村 理, 酒井 敏行. c-Met発現低下を介したγ-glutamylcyclotrasnferase(GGCT)阻害による前立腺がん細胞増殖抑制の新規分子機構の解明(Identification of c-Met as a novel target of gamma-glutamylcyclotrasnferase in a prostate cancer cell line). 日本泌尿器科学会総会. 2023. 110回. AOP09-07
Mitsuharu Masuda, Mano Horinaka, Shusuke Yasuda, Mie Morita, Emi Nishimoto, Hideki Ishikawa, Michihiro Mutoh, Toshiyuki Sakai. Discovery of cancer-preventive juices reactivating RB functions. Environmental Health and Preventive Medicine. 2023. 28. 54-54
片山勇輝, 谷村恵子, 森本健司, 堀中真野, 酒井敏行, 山田忠明. Mechanism of adaptive resistance to treatment with Lorlatinib via activation of EGFR signaling in ALK-rearranged non-small cell lung cancer. 日本がん分子標的治療学会学術集会プログラム・抄録集. 2022. 26th
Shogen Boku, Motoki Watanabe, Mamiko Sukeno, Takeshi Yaoi, Kiichi Hirota, Mahiro Iizuka, Kyoko Itoh, Yoshihiro Sowa, Yosuke Iizumi, Mitsuharu Masuda, et al. Combinatorial treatments of aspirin with glutaminolysis-targeting agents against PIK3CA-mutated colorectal cancer cells. ANNALS OF ONCOLOGY. 2021. 32. S309-S309
Shiori Umemura, Yoshihiro Sowa, Yosuke Iizumi, Toshiyuki Sakai. Synergistic effect of the inhibitors of RAF/MEK and AXL on KRAS-mutated ovarian cancer cells with high AXL expression. CANCER SCIENCE. 2021. 112. 771-771
