Rchr
J-GLOBAL ID：200901021968909539   Update date: Jan. 31, 2024

Sakai Toshiyuki

サカイ トシユキ | Sakai Toshiyuki
Affiliation and department：
Kyoto Prefectural University of Medicine Department of Drug Discovery Medicine

About Kyoto Prefectural University of Medicine Department of Drug Discovery Medicine


Job title： Professor
Other affiliations (1)：
  • 京都府立医科大学創薬医学講座  教授
Research field  (5)： Hygiene and public health (non-laboratory) ,  Hygiene and public health (laboratory) ,  Healthcare management, medical sociology ,  Pathobiochemistry ,  Pharmacology
Research keywords  (1)： 00
Research theme for competitive and other funds  (43)：
  • 2021 - 2026 ヘビの防御物質ブファジエノライド:食性進化のメカニズム解明
  • 2019 - 2024 Tailor-maid cancer prevention towards the era of preemptive medicine.
  • 2019 - 2023 Preventive strategy against arsenic carcinogenesis by TRAIL pathway activation and RB activation
  • 2017 - 2022 Research of molecular-targeting prevention against inflammatory diseases using chemical biology.
  • 2019 - 2021 Basic research for prevention of arteriosclerosis by cancer preventive ingredients with RB activation ability
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Papers (225)：
  • Mitsuharu Masuda, Mano Horinaka, Shusuke Yasuda, Mie Morita, Emi Nishimoto, Hideki Ishikawa, Michihiro Mutoh, Toshiyuki Sakai. Discovery of cancer-preventive juices reactivating RB functions. Environmental Health and Preventive Medicine. 2023. 28. 54-54
  • Yosuke Ota, Yukihiro Itoh, Takashi Kurohara, Ritesh Singh, Elghareeb E Elboray, Chenliang Hu, Farzad Zamani, Anirban Mukherjee, Yuri Takada, Yasunobu Yamashita, et al. Cancer-Cell-Selective Targeting by Arylcyclopropylamine-Vorinostat Conjugates. ACS medicinal chemistry letters. 2022. 13. 10. 1568-1573
  • 片山 勇輝, 谷村 恵子, 森本 健司, 堀中 真野, 酒井 敏行, 小笹 裕晃, 山田 忠明. ALK融合遺伝子陽性肺がんにおけるEGFRシグナル活性化を介したロルラチニブ初期治療抵抗性の解明とその克服(Adaptive resistance to lorlatinib by EGFR activation in ALK-rearranged non-small cell lung cancer cells). 日本癌学会総会記事. 2022. 81回. J-2014
  • Yosuke Iizumi, Yoshihiro Sowa, Wakana Goi, Yuichi Aono, Motoki Watanabe, Yoichi Kurumida, Tomoshi Kameda, Kenichi Akaji, Masatoshi Kitagawa, Toshiyuki Sakai. Stabilization of CDK6 by ribosomal protein uS7, a target protein of the natural product fucoxanthinol. Communications biology. 2022. 5. 1. 564-564
  • Motoki Watanabe, Shogen Boku, Kaito Kobayashi, Yoichi Kurumida, Mamiko Sukeno, Mitsuharu Masuda, Katsura Mizushima, Chikage Kato, Yosuke Iizumi, Kiichi Hirota, et al. A chemoproteoinformatics approach demonstrates that aspirin increases sensitivity to MEK inhibition by directly binding to RPS5. PNAS Nexus. 2022. 1. 2
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MISC (106)：
  • 片山勇輝, 谷村恵子, 森本健司, 堀中真野, 酒井敏行, 山田忠明. Mechanism of adaptive resistance to treatment with Lorlatinib via activation of EGFR signaling in ALK-rearranged non-small cell lung cancer. 日本がん分子標的治療学会学術集会プログラム・抄録集. 2022. 26th
  • Shogen Boku, Motoki Watanabe, Mamiko Sukeno, Takeshi Yaoi, Kiichi Hirota, Mahiro Iizuka, Kyoko Itoh, Yoshihiro Sowa, Yosuke Iizumi, Mitsuharu Masuda, et al. Combinatorial treatments of aspirin with glutaminolysis-targeting agents against PIK3CA-mutated colorectal cancer cells. ANNALS OF ONCOLOGY. 2021. 32. S309-S309
  • Shiori Umemura, Yoshihiro Sowa, Yosuke Iizumi, Toshiyuki Sakai. Synergistic effect of the inhibitors of RAF/MEK and AXL on KRAS-mutated ovarian cancer cells with high AXL expression. CANCER SCIENCE. 2021. 112. 771-771
  • 渡邉元樹, 朴将源, 宮本景子, 曽和義広, 飯泉陽介, 増田光治, 成田匠, 中尾俊雅, 武藤倫弘, 武藤倫弘, et al. 細胞外グルタミン濃度はがん予防薬の感受性に影響する. 日本衛生学雑誌(Web). 2021. 76. Supplement
  • 渡邉元樹, 山田恭正, 来見田遥一, 亀田倫史, 助野真美子, 飯塚まひろ, 曽和義広, 飯泉陽介, 高倉英樹, 宮本真吾, et al. ケモプロテオミクスおよび分子動力学シミュレーションが明らかにした,延命草の苦味成分ラブドシアノンIの標的タンパク質と抗腫瘍メカニズム. 電気泳動(Web). 2021. 65. Suppl
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Professional career (1)：
  • Doctor of Medicine
Committee career (2)：
  • American Association for Cancer Research Active corresponding member
  • 日本衛生学会 評議員
Awards (8)：
  • 2018 - 高松宮妃癌研究基金 高松宮妃癌研究基金学術賞
  • 2015 - 日本がん分子標的治療学会 日本がん分子標的治療学会 鶴尾隆賞
  • 2014 - 京都新聞 京都新聞大賞・文化学術賞
  • 2014 - 日本医師会 日本医師会医学賞
  • 2013 - 高松宮妃癌研究基金 高松宮妃癌研究基金研究助成金
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Association Membership(s) (4)：
American Association for Cancer Research ,  日本公衆衛生学会 ,  日本衛生学会 ,  日本癌学会
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