Hirotaka Watada

ワタダヒロタカ | Hirotaka Watada

Affiliation and department：
Homepage URL (1)： http://www.juntendo.ac.jp/graduate/laboratory/labo/taisya_naibunpitsu/index.html

Research field (1)： Metabolism and endocrinology

Research keywords (6)：インスリン抵抗性 , 動脈硬化 , インスリン , 膵β細胞 , オートファジー , 糖尿病学

Research theme for competitive and other funds (35)：

2023 - 2030 Interdisciplinary research on autophagy: From working principles to pathophysiology
2023 - 2026 Mechanisms of autophagy regulation and its disruption in pancreatic beta cells
2023 - 2026 妊娠期膵β細胞量増大および妊娠糖尿病発症におけるオートファジーの意義の解明
2023 - 2025 Pathophysiology of pancreatic beta cell insufficiency using a novel in vivo gene screening method
2021 - 2023 Discovery of new anti-diabetic drugs activating autophagy in beta cells

2020 - 2023 オートファジー不全による膵β細胞不全の分子メカニズムの解明

2019 - 2022 Optimization of beta-cell reprogramming driven by fasting-mimicking diet

2019 - 2021 Chronology of beta-cell failure with a novel time-resolved reporter system in mice

2018 - 2021 Research on "quantity" and "quality" of skeletal muscle aiming at comprehensive prevention of long-term care

2018 - 2021 Loss of p62 in pancreatic beta cells under autophagy deficiency had little effect on glucose tolerance and insulin secretion.

2017 - 2020 Cellular autophagy in alpha cells plays a role in the maintenance of islet architecture.

2017 - 2020 Autophagy deficiency cumulatively causes beta-cell failure.

2017 - 2020 Autophagic failure in islets

2016 - 2018 Autophagic failure of smooth muscle cells

2016 - 2018 Mechanism of pancreatice alpha cell neogenesis and maturation

2014 - 2017 Alteration of cellular status in diabetes and autophagy

2014 - 2016 膵β細胞オートファジー不全とp62陽性の封入体形成

2014 - 2016 Maturation Process of beta cells using New-timer mouse

2011 - 2014 Physiological substrate of beta cell autophagy

2011 - 2012 Regulation of the pancreatic beta-cell proliferation during non-pregnant period

2010 - 2012 Role of zinc transporters in beta-cell-autophagy induction

2009 - 2011 New insulin resistance regulatory factor "susceptibility to fat loading"

2009 - 2010 2型糖尿病の原因因子としての膵β細胞オートファジー機能不全

2008 - 2010 Mechanism of pancreatic beta cell expansion by bone marrow transplantation

2008 - 2009 Role of Hedgehog Signaling on the differentiation of pancreas and pancreatic beta-cell function

2007 - 2009 Molecular mechanism controlling PDX1 expression in vivo

2007 - 2008 New insulin resistance regulatory factor "susceptibility to fat loading"

2007 - 2008 高脂肪食負荷時における膵β細胞オートファジー機構の解析

2005 - 2006 膵β細胞に関わる転写因子の網羅的検索-プロテオミックスの手法を用いて-

2002 - 2005 OXIDATIVE STRESS AND EXERCISE : ESTABLISHMENT OF EXERCISE THERAPY FOR HEALTH PROMOTION AND PREVENTION OF DIABETES

2003 - 2004 膜4回貫通型蛋白CD9の膵ラ氏島分化及びインスリン分泌能における重要性の解明

2002 - 2004 The relation between the impaired islet microcirculation and diabetes

2002 - 2003 膵ランゲルハンス島前駆細胞の単離とそれを用いた再生療法の試み

2002 - 2003 膵臓前駆細胞から膵ラ氏島前駆細胞への分化メカニズムの解明

1997 - 1998 成長ホルモンの成長作用発現の分子メカニズムの解析-ドミナントネガティブSTAT分子を用いた解析-

Show all

Papers (500)：

Rukeye Tuerxun, Koji Kamagata, Yuya Saito, Christina Andica, Kaito Takabayashi, Wataru Uchida, Seina Yoshida, Junko Kikuta, Hiroki Tabata, Hitoshi Naito, et al. Assessing interstitial fluid dynamics in type 2 diabetes mellitus and prediabetes cases through diffusion tensor imaging analysis along the perivascular space. Frontiers in Aging Neuroscience. 2024. 16
Junko Sato, Kenichi Nakajima, Tomoya Mita, Mami Koshibu, Ayako Sato, Hiromasa Goto, Fuki Ikeda, Yuya Nishida, Katsumi Aso, Hirotaka Watada. Protocol of a Prospective Observational Study on Lifestyle and Quality of Life in Adults with Type 1 Diabetes in Japan. Diabetes therapy : research, treatment and education of diabetes and related disorders. 2024
Yoshifumi Negishi, Haruka Kaneko, Takako Aoki, Lizu Liu, Arepati Adili, Hitoshi Arita, Shinnosuke Hada, Masahiro Momoeda, Hui Huang, Jun Tomura, et al. Medial meniscus extrusion is invariably observed and consistent with tibial osteophyte width in elderly populations: The Bunkyo Health Study. Scientific reports. 2023. 13. 1. 22805-22805
Miwa Himuro, Yuka Wakabayashi, Tomomi Taguchi, Takehiro Katahira, Luka Suzuki, Hitoshi Iida, Takeshi Ogihara, Yuya Nishida, Shugo Sasaki, Francis C Lynn, et al. Novel time-resolved reporter mouse reveals spatial and transcriptional heterogeneity during alpha cell differentiation. Diabetologia. 2023
Hikaru Otsuka, Hiroki Tabata, Huicong Shi, Mari Sugimoto, Hideyoshi Kaga, Yuki Someya, Hitoshi Naito, Naoaki Ito, Abulaiti Abudurezake, Futaba Umemura, et al. Playing basketball and volleyball during adolescence is associated with higher bone mineral density in old age: the Bunkyo Health Study. Frontiers in Physiology. 2023. 14

ｍore...

MISC (574)：

佐藤隆史, 中川祐子, 深石貴大, 福中彩子, 綿田裕孝, 藤谷与士夫. マウス遺伝学的手法によるPpy遺伝子発現細胞の段階別運命追跡. 日本体質医学会雑誌. 2023. 85. 3
内藤仁嗣, 加賀英義, 染谷由希, 田端宏樹, 筧沙織, 田島翼, 伊藤直顕, 佐藤元津, 門脇聡, 綿田裕孝, et al. 高齢期における耐糖能悪化のメカニズムの解明(文京ヘルススタディー). 日本体質医学会雑誌. 2023. 85. 3
HIEN Bui Thu, 加賀英義, 筧沙織, 内藤仁嗣, 田端宏樹, 田島翼, 伊藤直顕, 綿田裕孝, 綿田裕孝, 田村好史, et al. 2型糖尿病の遺伝的リスクが同程度の糖尿病のある高齢者とない高齢者の代謝的特徴の比較. 日本体質医学会雑誌. 2023. 85. 3
内藤仁嗣, 田端宏樹, 新村直哉, 梅田暢大, 松本知也, 齋藤親, 加賀英義, 吉澤裕世, 筧佐織, 荒井秀典, et al. スマートフォンを用いた歩行動作解析の信頼性と臨床的意義. 日本サルコペニア・フレイル学会誌. 2023. 7. Supplement
坂本翔太, 筧佐織, ABUDUREZAKE Abulaiti, 大塚光, 石薈聡, 田端宏樹, 染谷由希, 内藤仁嗣, 木屋舞, 田島翼, et al. 日本の地域在住高齢者におけるGCKR多型の表現型に対するFGF21の媒介効果:文京ヘルススタディーによるMediation analysis. 糖尿病(Web). 2023. 66. Suppl

ｍore...

Education (2)：

- 1997 大阪大学大学院医学研究科
- 1990 Osaka University Faculty of Medicine

Professional career (1)：

医学 (大阪大学)

Committee career (4)：

2020/04 - 現在日本学術振興会学術システム研究センター専門研究員
2014 - 現在日本糖尿病学会理事
2014 - 2016 大学設置・学校法人審議会専門委員 <医学専門委員会>
2014 - 2015 日本専門医機構専門医制度検討委員会委員

Awards (4)：

2012 - 日本糖尿病肥満動物学会研究賞
2009 - 日本医師会研究助成
2009 - 日本内分泌学会研究奨励賞
2009 - 日本糖尿病学会リリー賞

Association Membership(s) (3)：

日本糖尿病学会 , 日本内科学会 , 日本内分泌学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page