Rchr

J-GLOBAL ID：200901022425937792 Update date: Apr. 29, 2024

Kiyohiro Houkin

ホウキンキヨヒロ | Kiyohiro Houkin

Affiliation and department：
Job title： President
Homepage URL (1)： http://www.neurosurgery-hokudai.jp/

Research field (1)： Neurosurgery

Research keywords (29)：血管内皮前駆細胞 , human , Linkage analysis , Moyamoya disease , サイトカイン , Microsatellite analysis , Mitochondria , 遺伝子 , 脳血管 , cytokine receptor , Brain , Cardiopulmonary arrest , Apoptosis , Malignant glioma , もやもや病 , growth factor , positional cloning , Bcl-2 , Receptor , Neurofibromatosis type 1 , 腫瘍免疫 , cytokine , autocrine loop , gene expression , 脳神経疾患 , Chromosome 17 , イオンチャネル , 脳腫瘍 , Neurosurgery

Research theme for competitive and other funds (38)：

2019 - 2024 Comprehensive validation of circulating microRNA signatures for Moyamoya disease early detection as an epigenome blood biomarker
2019 - 2022 Development of neruoprotectice therapy by artificial oxygen carriier with antioxidant function
2019 - 2022 脳動脈瘤破裂機構解明へ向けた分子生物学的・血行力学的統合解析と新規薬剤治療の開拓
2018 - 2021 Relationship between Chronic inflammation and progression of Moyamoya disease
2017 - 2020 Development of visible particle embolic material used by new concept hydrogel

2016 - 2019 Development of neuroprotective therapy with selective intra-arterial infusion of cold artificial oxygen carrier

2015 - 2018 Can inflammation worsen the prognosis of severe subarachnoid hemorrhage

2015 - 2018 Investigation of barrier function of endothelial cells derived from moyamoya disease-specific iPS cells

2015 - 2018 Development of an anti-rupture drug treatment method using a novel animal model of easily rupturable large cerebral aneurysm and human clinical specimen

2015 - 2018 Elucidation of the pathology of spinal cord adhesive arachnoiditis and establishment of treatment

2015 - 2017 Induction of smooth muscle cells from iPS cells derived from moyamoya disease patient

2013 - 2016 Genome-wide CNV array analysis in parent-offspring pairs with Moyamoya disease with and without clinical anticipation

2013 - 2015 The role of SIRT1 in cellular senescence and characteristics in brain microvascular endothelial cells

2012 - 2015 Development of regional brain hypothremia by trans-ventricular and trans-arterial cold infusion in acute cerebral ischemia

2012 - 2015 Analysis for circulating endothelial progenitor cells in moyamoya disease

2011 - 2014 Autologous Bone Marrow Stromal Cell Transplantation for Stroke: Steps to Standardize the Clinical Protocols

2011 - 2013 The method of "pre and post " graduate medical education that correct regional disparity

2011 - 2012 Elucidation of the rupture mechanism By immunohistological analysis and computed fluid dynamics analysis according to the aneurysmal wall proparties in human ruptured cerebral aneurysm.

2009 - 2011 Endovascular treatment of experimental aneurysms in swine model by use of mesenchymal stem cells-coated stents.

2009 - 2011 Therapeutic benefits of bone marrow stem cells after global cerebral ischemia

2008 - 2011 Therapeutic benefits of the genetically-engineering mesenchymal stem cells for acute cerebral ischemia

2008 - 2010 Postgraduate occupational education for stroke care workers in depopulated community by stroke team

2008 - 2010 Therapeutic benefits of intravenous administration of genetically-engineering mesenchymal stem cells on spinal cord injury

2007 - 2009 Therapeutic benefits of intravenous administration of mesenchymal stem cells on spinal cord injury-Contribution of Diacylglycerol to neurogenesis-

2007 - 2009 Elucidation of the role of intramedullary microcirculation in the pathogenesis of syringomyelia and the possibility of a new treatment

2006 - 2007 くも膜下出血後の脳血管攣縮でのR型カルシウムチャネルを標的とする新治療法の展開

2004 - 2007 A genetically-engineering bone marrow stem cell therapy for stroke

2004 - 2006 Therapeutic benefits of mesenchymal stem cells derived from peripheral blood on spinal cord injury

2004 - 2005 心肺停止・蘇生後脳症におけるアポトーシス検出画像の開発

2002 - 2004 Investigation of causative gene of familial occurrence of idiopathic occlusion of Willis ring

2002 - 2003 Functional recovery of the cerebral tissue following transplantation of the genetically-engineering bone marrow stem cells.

1999 - 2001 Searching the Causative Gene of Familial Moyamoya Disease (Spontaneous Occlusion of the Circle of Willis)

1999 - 2001 Role of Mitochondrial Permeability Transition in Ischemic Neuronal Cell Death

1999 - 2000 神経膠腫におけるミトコンドリア透過性遷移とBcl-2ファミリー蛋白発現の解析

1996 - 1998 Microsatellite linkage analysis for determination of disease locus of Moyamoya disease.

1993 - 1995 Study on the abnormal expression of cytokine and growth factor genes in human malingnant gliomas.

もやもや病の外科治療、遺伝子解析

脳卒中の外科治療

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Papers (594)：

Masahito Kawabori, Satoshi Kuroda, Hideo Shichinohe, Kaoru Kahata, Souichi Shiratori, Satoshi Ikeda, Taisuke Harada, Kenji Hirata, Khin Khin Tha, Masato Aragaki, et al. Intracerebral transplantation of MRI-trackable autologous bone marrow stromal cells for patients with subacute ischemic stroke. Med (New York, N.Y.). 2024
Kiyohiro Houkin, Toshiya Osanai, Shinichiro Uchiyama, Kazuo Minematsu, Akihiko Taguchi, Katsuhiko Maruichi, Yoshimasa Niiya, Katsuyuki Asaoka, Yoshihiro Kuga, Katsumi Takizawa, et al. Allogeneic Stem Cell Therapy for Acute Ischemic Stroke. JAMA Neurology. 2024
Yuki Takakura, Mika Otsuki, Ryo Takagi, Kiyohiro Houkin. A validation study for wide-range remote assessment of cognitive functions in the healthy older Japanese population: a pilot randomised crossover trial. BMC geriatrics. 2023. 23. 1. 575-575
Yasuhiro Nishiyama, Kazumi Kimura, Toshiaki Otsuka, Kazunori Toyoda, Shinichiro Uchiyama, Haruhiko Hoshino, Nobuyuki Sakai, Yasushi Okada, Hideki Origasa, Hiroaki Naritomi, et al. Dual Antiplatelet Therapy With Cilostazol for Secondary Prevention in Lacunar Stroke: Subanalysis of the CSPS.com Trial. Stroke. 2023. 54. 3. 697-705
Yasuhiro Morii, Kagari Abiko, Toshiya Osanai, Jiro Takami, Takumi Tanikawa, Kensuke Fujiwara, Kiyohiro Houkin, Katsuhiko Ogasawara. Cost-effectiveness of seven-days-per-week rehabilitation schedule for acute stroke patients. Cost effectiveness and resource allocation : C/E. 2023. 21. 1. 12-12

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MISC (1,215)：

伊東雅基, 内野晴登, 川堀真人, 杉山拓, 数又研, 宝金清博, 藤村幹. 成人もやもや病に対する直接・間接複合血行再建術後のバイパス路発達の術前要因. 日本分子脳神経外科学会プログラム・抄録集. 2022. 22nd
江口克紀, 白井慎一, 松島理明, 加納崇裕, 山崎和義, 濱内祝嗣, 笹森徹, 関俊隆, 北川まゆみ, 大槻美佳, et al. 機械学習による歩行動画からのパーキンソン病患者UPDRSスコアの予測. パーキンソン病・運動障害疾患コングレスプログラム・抄録集. 2021. 15回. 75-75
寳金清博. 日本学術会議in北海道 : 「ふるさと」から学術を考える (特集地方学術会議). 学術の動向 = Trends in the sciences. 2021. 26. 6. 24-27
杉山拓, 寳金清博. 治療法の再整理とアップデートのために専門家による私の治療くも膜下出血. 日本医事新報. 2021. 5067. 38-39
江口克紀, 矢部一郎, 白井慎一, 松島理明, 加納崇裕, 山崎和義, 濱内祝嗣, 笹森徹, 関俊隆, 北川まゆみ, et al. パーキンソン病における両側STN-DBS後の体重増加と刺激位置との関連についての検討. パーキンソン病・運動障害疾患コングレスプログラム・抄録集. 2021. 14回. 83-83

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Patents (8)：

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Books (28)：

脳と頭蓋底の血管系アトラス : 臨床解剖のバリエーション
医学書院 2018 ISBN:9784260034579
脳血管障害診療のエッセンス (日本医師会生涯教育シリーズ)
メジカルビュー社 2017 ISBN:475831778X
Cell therapy against cerebral stroke : comprehensive reviews for translational researches and clinical trials
Springer 2017 ISBN:9784431560579
脳血管障害 : 診療のエッセンス
日本医師会 2017
脳血管障害診療のエッセンス
日本医師会,メジカルビュー社 (発売) 2017 ISBN:9784758317788

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Education (3)：

1996 - 1996 米国スタンフォード大学・英国王立神経研究所文部科学省在外研究員
1986 - 1989 米国カリフォルニア大学デービス校客員研究員
1973 - 1979 Hokkaido University School of Medicine

Professional career (1)：

Ph. D. (Medical Science)

Work history (11)：

2020/10 - 現在 Hokkaido University President
2019/09 - 2020/09 Hokkaido University Graduate School of Health Sciences
2017/04 - 2019/03 Hokkaido University
2013/04 - 2019/03 Hokkaido University Hokkaido University Hospital
2010/03 - 2019/03 Hokkaido University Graduate School of Medicine

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Committee career (6)：

2014/10 - 現在日本学術会議会員
- 現在国際観光医療学会理事
- 現在国際臨床医学会理事
- 現在日本脳卒中学会理事
- 現在日本脳循環代謝学会理事

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Awards (6)：

2018/10 - 伊藤太郎学術賞
2017/10 - 斎藤眞賞
2013/02 - 公益信託美原脳血管障害研究振興基金美原賞
2007/09 - 北海道医師会賞・北海道知事賞
1999/04 - 日本脳卒中の外科学会賞(鈴木賞)

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Association Membership(s) (15)：

米国脳神経外科アカデミー , 米国心臓病学会(AHA) , 日本脳循環代謝学会 , 日本学術会議 , 米国脳神経外科学会 , 米国脳神経外科コングレス , 国際磁気共鳴医学会 , 米国脳卒中学会 , 日本脳神経外科学会 , 日本脳卒中学会 , The American Association of Neurological Surgeons , The Congress of Neurological Surgeons , The International Society for Magnetic Resonance in Medicine , The American Stroke Association , The Japan Neurosurgical Society

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