2012 - 2015 Molecular mechanisms of DNA homology search involving nucleosomes
構造解析用核内タンパク質等の生産と評価
クロマチン動構造の国際共同研究ネットワーク形成
再構成ヌクレオソームを用いた動的クロマチン構造の解明
動的クロマチン構造と機能
クロマチンDNAにおける相同的組換え機構に関する研究
ヒトにおける相同DNA組換えの分子機構に関する研究
染色体の安定維持に重要なヒトRad51ファミリータンパク質の構造、機能解析
STUDY ON RATIONAL DEVELOPMENT OF NOVEL ANTIBIOTICS TAGRETING DnaA DOMAIN IV
がん化防御に重要なDNA組換え修復装置の構造および機能解析
ヒトDNA組換え修復装置による発がん防御の分子機構の解析
DNA組換え修複による発がん防御の分子メカニズム
特殊なDNA構造に結合する新規タンパク質の同定とその立体構造予測に関する研究
ヒトDNA組換え装置サブユニットの高次構造と機能に関する研究
Molecular Mechanism of Bacterial Chromosome Partitioning dependent on a Centromere like site migS
Protein Dynamics in Complex Apparatus for the Initiation and Regulation of the Chromosomal Replication
DNA組換え修復タンパク質群による発がん防御の分子機構
単鎖DNA結合タンパク質の新規立体構造モチーフ解析とデータベースからの検索
染色体ダイナミクスに関わるタンパク質の構造・機能解析
発がんの原因となる二重鎖切断を正確に修復する相同組換え装置の機能・構造解析
Structural dynamics and functions of proteins involved in homologous recombination
Bioinformatics in silico by the Unification of Symobols and Patterns
発がん防御に重要な新規二重鎖切断修復タンパク質の探索とその機能・構造解析
染色体ダイナミクスの生化学・構造生物学的解析
Molecular organization and dynamics in chromatin domains for gene expression control
The physicochemical field for genetic activities
二重鎖切断修復に働く新規発がん防御因子の探索とその機能・構造解析
Structural and functional studies for nuclear macromolecular complexes
The structural analysis of centromere specific nucleosome
Functional analysis of cis-and trans-acting factors to govern chromatin dynamisms in transcriptional regulation
Identification and biochemical analyses of novel factors that are involved in homologous recombination reaction
Analyses of centromeric chromatin structure
クロマチンにおける相同組換えの分子機構に関する研究
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Papers (342)：
Masahiro Shimizu, Hiroki Tanaka, Masahiro Nishimura, Nobuhiro Sato, Kayo Nozawa, Haruhiko Ehara, Shun-ichi Sekine, Ken Morishima, Rintaro Inoue, Yoshimasa Takizawa, et al. Asymmetric fluctuation of overlapping dinucleosome studied by cryo-electron microscopy and small-angle X-ray scattering. PNAS Nexus. 2024
Goto N, Suke K, Yonezawa N, Nishihara H, Handa T, Sato Y, Kujirai T, Kurumizaka H, Yamagata K, Kimura H. ISWI chromatin remodeling complexes recruit NSD2 and H3K36me2 in pericentromeric heterochromatin. Journal of Cell Biology. 2024. 223. 8. e202310084
Takayuki Hoshii, Sota Kikuchi, Tomoya Kujirai, Takeshi Masuda, Tomoko Ito, Satoshi Yasuda, Makoto Matsumoto, Bahityar Rahmutulla, Masaki Fukuyo, Takeshi Murata, et al. BOD1L mediates chromatin binding and non-canonical function of H3K4 methyltransferase SETD1A. Nucleic acids research. 2024
Osakabe A, Takizawa Y, Horikoshi N, Hatazawa S, Negishi L, Sato S, Berger F, Kakutani T, Kurumizaka H. Molecular and structural basis of the chromatin remodeling activity by Arabidopsis DDM1. Nature Communications. 2024. 15. 1. 5187-5187
Tomoaki Kimura, Seiya Hirai, Tomoya Kujirai, Risa Fujita, Mitsuo Ogasawara, Haruhiko Ehara, Shun-Ichi Sekine, Yoshimasa Takizawa, Hitoshi Kurumizaka. Cryo-EM structure and biochemical analyses of the nucleosome containing the cancer-associated histone H3 mutation E97K. Genes to cells : devoted to molecular & cellular mechanisms. 2024
Visualization of the native nucleosome containing the histone variant H2A.X
(RIKEN International Symposium on Nuclear Structure and Function 2024)
The accumulation mechanism of the homologous recombination protein RAD51 at double-strand break sites in chromatin
(RIKEN International Symposium on Nuclear Structure and Function 2024)
Regulation of nucleosomal transcription by centromeric protein CENP-B
(RIKEN International Symposium on Nuclear Structure and Function 2024)
Chromatin architecture as an eukaryotic genome regulator
(RIKEN International Symposium on Nuclear Structure and Function 2024)
