Rchr
J-GLOBAL ID：200901022651952788   Update date: May. 25, 2024

Hotta Hak

ホツタ ハク | Hotta Hak
Affiliation and department：
Kobe University Graduate School of Medicine

About Kobe University Graduate School of Medicine


Research field  (1)： Virology
Research keywords  (5)： hepatitis B virus ,  Molecular Epidemiology ,  Molecular Biology ,  Measles virus ,  Hepatitis C virus
Research theme for competitive and other funds  (65)：
  • 2018 - 2021 Identification of the budding site of hepatitis B virus infectious particles (Dane particles)
  • 2015 - 2017 Tyrosine phosphorylation of a viral protein in the hepatitis C virus life cycle
  • 2014 - 2017 Study on regulation of immune target in hepatocytes using iPS cells
  • 2013 - 2017 Analysis of influence of hepatitis C virus and Plasmodium falciparum proteins specifically expressed at liver on growth of HCV and P. falciparum.
  • 2014 - 2017 新規経口ワクチンを用いたC型慢性肝炎治療法の開発研究
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Papers (238)：
  • Kento Sakamoto, Miho Konami, Shinra Kameda, Yuto Satoh, Hiroshi Wakimoto, Yoshinori Kitagawa, Bin Gotoh, Da-Peng Jiang, Hak Hotta, Masae Itoh. Suppression of viral RNA polymerase activity is necessary for persistent infection during the transformation of measles virus into SSPE virus. PLoS pathogens. 2023. 19. 7. e1011528
  • Chie Aoki-Utsubo, Puguh Indrasetiawan, Kento Fukano, Masamichi Muramatsu, Nina Artanti, Muhammad Hanafi, Hak Hotta, Masanori Kameoka. Amentoflavone inhibits hepatitis B virus infection via the suppression of preS1 binding to host cells. Microbiology and Immunology. 2023. 67. 6. 281-292
  • Chie Aoki-Utsubo, Muhammad Hanafi, Destia Tri Armanti, Hiroyuki Fuchino, Nobuo Kawahara, Sri Hartati, Aty Widyawaruyanti, Pratiwi Sudarmono, Masanori Kameoka, Hak Hotta. Identification of an Oligostilbene, Vaticanol B, from Dryobalanops aromatica Leaves as an Antiviral Compound against the Hepatitis C Virus. Biological & pharmaceutical bulletin. 2023. 46. 8. 1079-1087
  • Adita Ayu Permanasari, Chie Aoki-Utsubo, Tutik Sri Wahyuni, Lidya Tumewu, Myrna Adianti, Aty Widyawaruyanti, Hak Hotta, Achmad Fuad Hafid. An in vitro study of an Artocarpus heterophyllus substance as a hepatitis C antiviral and its combination with current anti-HCV drugs. BMC Complementary Medicine and Therapies. 2021. 21. 1
  • Yuto Satoh, Kurara Higuchi, Daichi Nishikawa, Hiroshi Wakimoto, Miho Konami, Kento Sakamoto, Yoshinori Kitagawa, Bin Gotoh, Da-Peng Jiang, Hak Hotta, et al. M protein of subacute sclerosing panencephalitis virus, synergistically with the F protein, plays a crucial role in viral neuropathogenicity. The Journal of general virology. 2021. 102. 10
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MISC (63)：
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Patents (2)：
  • 免疫原性ポリペプチド表層発現ビフィズス菌
  • P53癌抑制蛋白との結合に関与するC型肝炎ウィルス非構造蛋白NS3のアミノ酸残基の同定と、医薬開発への利用
Books (45)：
  • Compact Microbiology
    南江堂 2021 ISBN:9784524226368
  • シンプル微生物学(改訂第6版)
    2018 ISBN:9784524254835
  • コンパクト微生物学(改訂第4版)
    2015 ISBN:9784524265374
  • 医学大辞典
    南山堂 2015 ISBN:9784525010805
  • 厚生労働科学研究費補助金 B型肝炎創薬実用化等研究事業 B型肝炎ウイルスの感染複製機構の解明に関する研究 平成26年度総括・分担研究報告書 / B型肝炎ウイルスタンパク質と相互作用する宿主タンパク質の構造と機能の解析
    厚生労働省 2015
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Lectures and oral presentations  (303)：
  • Dryobalanops aromatica 葉部からのオリゴスチルベノイド、vaticanol B は C 型 肝炎ウイルスの感染を阻害する
    (日本薬学会第137年会 2017)
  • Genetic variation of hepatitis C virus.
    (Universitas Gadjah Mada 2016)
  • Anti-flavivirus compounds from natural resources.
    (Kobe University Academic Research and Education Forum (KUAREF) Pre-conference 2016)
  • Seroevidence for high prevalence of infections with avian influenza A(H5N1) virus among workers in a live poultry market in Indonesia.
    (第64回日本ウイルス学会学術集会 2016)
  • Upregulation of MAPK phosphatase 3 is involved in HCV-induced dephosphorylation of FoxO1.
    (23rd International Symposium on Hepatitis C Virus and Related Viruses 2016)
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Education (3)：
  • 1980 - Kobe University
  • - 1974 医師国家試験合格
  • 1968 - 1974 Osaka University Faculty of Medicine
Professional career (1)：
  • 医学博士 (神戸大学)
Work history (14)：
  • 2023/09 - 現在 Honorary Member, Japanese Society of Virology
  • 2015/04 - 現在 Kobe University Professor Emeritus
  • 2013/02 - 現在 Airlangga University
  • 2018/04 - 2022/03 Konan Women's University Faculty of Clinical Nutrition and Dietetics Professor
  • 2015/07 - 2018/03 Kobe University Graduate School of Health Sciences Endowed Professor
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Awards (2)：
  • 2019 - Marquis Who's Who Albert Nelson Marquis Lifetime Achievement Award A leader in the Medical microbiology education
  • 2009/02 - Asia-Pacific Society for Medical Virology Excellence Award Sequence variation of the hepatitis C virus genome and its correlation with viral pathogenicity.
Association Membership(s) (7)：
アメリカ微生物学会 ,  アメリカ科学振興協会 ,  日本免疫学会 ,  日本癌学会 ,  日本肝臓学会 ,  日本細菌学会 ,  日本ウイルス学会
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