Research field (1)：
Applied molecular and cellular biology
Research keywords (5)：
recombinant protein production
, Tumour
, Gene Amplification
, micronuclei
, Extrachromosomal Element
Research theme for competitive and other funds (14)：
2016 - 2019 Extrachromosomal elements of human genomic origin------from its basic understanding to the innovative cell technology
2014 - 2016 Generation of extrachromosomal elements by the human chromosome pulverization, and its applicaiton to the develoopment of novel episomal vector
2011 - 2015 Advancement of revolutional cell technology based on the IR/MAR gene amplification method
2012 - 2014 Control of gene amplification-rate in animal cells, and its application
2009 - 2010 悪性形質を運ぶ染色体外遺伝因子の細胞外放出による細胞間水平伝播
2007 - 2008 微小核ダイナミクス・・・異常クロマチンの廃棄システム
2005 - 2008 自律複製する染色体外遺伝因子の細胞内動態と細胞外排出を支配する分子機構
2002 - 2004 Mechanism that govern the intracellular dynamics and elimination of extrachromosomal genetic element
2002 - 2003 染色体外での自律的複製を評価する新規実験系を用いた、哺乳動物複製起点の解析
2000 - 2001 特定染色体領域に濃縮される核マトリックス構成RNAの解析
1999 - 2001 Selective elimination mechanism of extrachromosomal autonomously replicating genetic element mediated by the micronucleation
1998 - 1999 Mechanism of Active Elimination of Amplified Oncogenes
1997 - 1998 The Examination of the Infectious Chromatin Hypothesis and the Development of an Experimental System for the DM-transfer Mediated by the Extracellular Micronuclei
1995 - 1997 Active Elimination of Amplified Oncogenes from Tumor Cells
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Papers (61)：
Ryonosuke Taniguchi, Koichi Utani, Bhushan Thakur, Kazuho Ishine, Mirit I. Aladjem, Noriaki Shimizu. SIRT1 stabilizes extrachromosomal gene amplification and contributes to repeat-induced gene silencing. Journal of Biological Chemistry. 2021. 296. 100356-100356
Yusuke Ogaki, Miki Fukuma, Noriaki Shimizu. Repeat induces not only gene silencing, but also gene activation in mammalian cells. PLoS ONE. 2020. 15. 6. e0235127
Takahito Ohira, Koichi Miyauchi, Narumi Uno, Noriaki Shimizu, Yasuhiro Kazuki, Mitsuo Oshimura, Hiroyuki Kugoh. An efficient protein production system via gene amplification on a human artificial chromosome and the chromosome transfer to CHO cells. Scientific reports. 2019. 9. 1. 16954-16954
Manami Asoshina, Genki Myo, Natsuko Tada, Koji Tajino and Noriaki Shimizu. Targeted amplification of a sequence of interest in artificial chromosome in mammalian cells. Nucleic Acids Research. 2019. 47. 11. 5998-6006
Yoshio Araki, Chiemi Noguchi, Tetsuro Hamafuji, Hiroshi Nose, Daisuke Miki, Noriaki Shimizu. Application of the novel and convenient IR/MAR gene amplification technology to the production of recombinant protein pharmaceuticals. BMC Proceedings. 2011. 5. Suppl 8. 131-131
Education (2)：
1980 - 1983 Kyoto University Graduate School, Division of Natural Science
1974 - 1978 Kyoto University Faculty of Agriculture
Professional career (2)：
Master of Science (Kyoto University)
Doctor of Science (Kyoto University)
Work history (7)：
2008/02 - 2021/03 Graduate School of Biosphere Science Professor
2007/04 - Graduate School of Biosphere Science Associate Professor
2006/04 - Graduate School of Biosphere Science, Hiroshima University Associate Professor
1994/04/01 - 1995/09/30 The Salk Institute for Biological Studies Visiting Scientist
1992/04 - Faculty of INtegrated Arts and Sciences, Hiroshima University Associate Professor
1988/12 - Faculty of Integrated Arts and Sciences Assistant Professor
1983/04/01 - 1988/11/30 Yamanouchi Pharmaceutical Co. Ltd. Central Research Laboratories Researcher
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Association Membership(s) (5)：
The Society for Biotechnology, Japan
, Japanese Association for Animal Cell Technology
, Japanese Cancer Association
, The Japanese Biochemical Society
, The Molecular Biology Society of Japan
