Rchr
J-GLOBAL ID:200901023619301100
Update date: Dec. 18, 2024
Katsuhiko Shirahige
シラヒゲ カツヒコ | Katsuhiko Shirahige
Affiliation and department:
Other affiliations (1):
Research field (4):
Molecular biology
, Genetics
, Systems genomics
, Genomics
Research keywords (15):
Genome Analysis
, Chromosome function
, Genome function
, Chromosomal replication
, Microbiome
, Cancer
, Transcriptional Regulation
, Chromosome Structure
, Chromosome Dynamics
, Genetic disease
, Cohesin
, Chromosome
, Genome Structure
, 分子生物学
, Molecular Biology
Research theme for competitive and other funds (39):
- 2022 - 2025 Elucidation of regulatory mechanisms of lipid metabolism in meibomian glands by changes in aging and indigenous bacterial flora
- 2020 - 2025 Genomic modalities of development and differentiation and elucidation of disease mechanisms by their malfunction
- 2020 - 2025 Genome modality: understanding physical properties of the genome
- 2020 - 2025 Regulation of Enhanceosome by Cohesin
- 2021 - 2024 Molecular mechanism of nuclear speckle disorders: NKAP-related syndrome as a model
- 2019 - 2022 Elucidation of the pathogenesis of the ocular surface diseases associated with meibomian gland lipids, commensal bacteria and sex steroid hormones
- 2020 - 2021 Chromosome Orchestration System
- 2020 - 2021 Role of Cohesin, a DNA motor, in transcriptional elongation
- 2015 - 2020 Chromosome OS
- 2015 - 2020 4D Chromosome structural information during differentiation
- 2015 - 2020 Chromosome Orchestration System
- 2015 - 2020 Chromosome Orchestration System
- 2016 - 2018 染色体機能を制御するコヒーシンタンパクの動態解析
- 2015 - 2018 Study of genome maintenance / inheritance mechanism based on chromosome 4D structure analysis
- 2014 - 2017 Study on the reactivation of regenerative ability by masking 'autoantigens' expressed in organ blastema.
- 2014 - 2017 Host nuclear network responsible for the pathology of virus infection
- 2013 - 2016 Functional analysis of epigenetic intreating factors during heart regeneration
- 2010 - 2016 Systematic understanding of genome adaptation
- 2010 - 2015 A novel approach for the understanding of basic structure and behavior of human chromosomes
- 2010 - 2015 Development of bioinformatics platform for analyzing chromosome dynamics and comparative genomics.
- 2010 - 2015 Understanding the "genome adaptation" in fertilized embryo
- 2012 - 2012 Remodelling transcriptional activities via chromation-histone modulators during heart regeneration
- 2010 - 2012 Functional analysis of chromatin dynamics during aging by genomic approach
- 2006 - 2010 A Novel Genomic Approch for the Understanding of the Structure and Function of Chromosomes
- 2005 - 2009 Links Between S-phase and M-phase Mediated by Fork Protection Complex
- 2005 - 2005 染色体複製異常を防御する分子機構の解明
- 2003 - 2005 The systematic approach for the understanding of dynamic aspects of chromosome VI of S.cerevisiae
- 2001 - 2005 Regulation of initiation and elongation stages of DNA replication
- 2004 - 2004 タンパク結合プロファイルに基づいた染色体代謝ネットワークの解析
- 2004 - 2004 ゲノム上の核マトリックス結合部位の網羅的解析とそのダイナミクス
- 1999 - 2004 染色体機能装置のダイナミクスとアルゴリズム
- 1999 - 2003 真核生物染色体のS期に於ける動態の全て-出芽酵母第六染色体をモデルとして
- 1996 - 1999 Regulation of initiation of chromosome replication
- 1995 - 1996 AN IMPROVED IN VIVO DNA FOOT PRINTING BY A NON-RADIOISOTOPE DNA
- 1995 - 1996 Mechanism of Initiation of Replication of the Chromosome VI of Saccharomyces cerevisiae
- 1995 - 1995 酵母ARS機能に及ぼす染色体構造の役割り
- 1995 - 1995 複製因子PCNAと細胞周期調節因子p21の相互作用
- アフィメトリクスGeneChipを用いたゲノム解析
- Genomic analyses by Affymetrix GeneChip system
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Papers (218):
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Eiko SAIJOU, Yoshiko Kamiya, Katsunori Fujiki, Katsuhiko Shirahige, Ryuichiro Nakato. Modulation of Liver Cholesterol Homeostasis by Choline Supplementation During Fibrosis Resolution. Heliyon. 2024. e36727-e36727
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Yoshikazu Nagagaki, Yuji Kozakura, Theventhiran Mahandaran, Yukiko Fumoto, Ryuichiro Nakato, Katsuhiko Shirahige, Fuyuki Ishikawa. Histone H3.3 chaperone HIRA renders stress-responsive genes poised for prospective lethal stresses in acquired tolerance. Genes to Cells. 2024
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Aiko Iwata-Otsubo, Cara M Skraban, Atsunori Yoshimura, Toyonori Sakata, Cesar Augusto P Alves, Sarah K Fiordaliso, Yukiko Kuroda, Jaime Vengoechea, Angela Grochowsky, Paige Ernste, et al. Biallelic variants in GTF3C5, a regulator of RNA polymerase III-mediated transcription, cause a multisystem developmental disorder. Human genetics. 2024. 143. 3. 437-453
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Momoko Fukuda, Yuki Fujita, Yuko Hino, Mitsuyoshi Nakao, Katsuhiko Shirahige, Toshihide Yamashita. Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem Cells in the Subventricular Zone. International Journal of Molecular Sciences. 2024. 25. 5. 2540-2540
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Kristian Jeppsson, Biswajit Pradhan, Takashi Sutani, Toyonori Sakata, Miki Umeda Igarashi, Davide Giorgio Berta, Takaharu Kanno, Ryuichiro Nakato, Katsuhiko Shirahige, Eugene Kim, et al. Loop-extruding Smc5/6 organizes transcription-induced positive DNA supercoils. Molecular cell. 2024
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MISC (124):
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吉村充騎, 梶谷嶺, 伊藤武彦, 坂東優篤, 白髭克彦. Function of cohesin loader NIPBL/MAU2 in RNA quality control. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
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吉田圭介, 前川利男, LY Nhung Hong, LY Nhung Hong, 藤田晋一郎, 村谷匡史, 安藤美波, 加藤由紀, 荒木啓充, 三浦史仁, et al. 父親マウスの低タンパク食の影響の遺伝は,ATF7に依存する. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
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Jeff S. Piotrowski, Sheena C. Li, Raamesh Deshpande, Scott W. Simpkins, Justin Nelson, Yoko Yashiroda, Jacqueline M. Barber, Hamid Safizadeh, Erin Wilson, Hiroki Okada, et al. Functional annotation of chemical libraries across diverse biological processes (vol 13, pg 982, 2017). NATURE CHEMICAL BIOLOGY. 2017. 13. 12. 1286-1286
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Jeff S. Piotrowski, Sheena C. Li, Raamesh Deshpande, Scott W. Simpkins, Justin Nelson, Yoko Yashiroda, Jacqueline M. Barber, Hamid Safizadeh, Erin Wilson, Hiroki Okada, et al. Functional annotation of chemical libraries across diverse biological processes (vol 13, pg 982, 2017). NATURE CHEMICAL BIOLOGY. 2017. 13. 12. 1286-1286
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古俣 麻希子, 立花 広太, 井上 玄志, 須谷 尚史, 白髭 克彦, 伊藤 武彦, 森川 あすか. 次世代シークエンサーを用いた日本人女性顔面細菌叢の大規模解析. 日本香粧品学会誌. 2017. 41. 3. 222-223
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Books (2):
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Genomic Approach for the Understanding of Dynamic Aspect of Chromosome Behavior
Elsevier Life Sciences (CA) 2006
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Genomic Approach for the Understanding of Dynamic Aspect of Chromosome Behavior
Elsevier Life Sciences (CA) 2006
Lectures and oral presentations (2):
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Cohesin mediates transcriptional insulation by CCCTC-binding factor.
(2008)
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Cohesin mediates transcriptional insulation by CCCTC-binding factor.
(2008)
Works (2):
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酵母のゲノム解析
1999 -
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Genomic Analyses of Brewing Yeasts
1999 -
Education (3):
- - 1994 Osaka University
- - 1994 Osaka University Graduate School, Division of Medical Science
- - 1988 The University of Tokyo College of Arts and Sciences Department of Basic Science
Professional career (1):
- Doctor of Medical Science (Osaka University)
Work history (9):
- 2024/02 - 現在 Karolinska Institutet Department of Cell and Molecular Biology Visiting Professor
- 2018/04 - 現在 The University of Tokyo Institute for Quantitative Biosciences Professor
- 2017/04 - 2018/03 The University of Tokyo Institute of Molecular and Cellular Biosciences Director
- 2010/02 - 2018/03 The University of Tokyo Institute for Molecular and Cellular Biosciences Professor
- 2007 - 2010/02 Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology Professor
- 2004 - 2007 Tokyo Institute of Technology Gene Research Center Assistant Professor
- 2001 - 2004 RIKEN GENOMIC SCIENCE CENTER Senior Researcher
- 1995 - 2001 Nara Advanced Institute of Science and Technology Department of Biology Associate Professor
- 1994 - 1995 Nara Advanced Institute of Science and Technology Department of Biology JSPS Research Fellow
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Awards (4):
- 2010 - Ministry of Education, Culture, Sports, Science and Technology Prizes for Science and Technology (Research Category)
- 2009 - Japan Society for the Promotion of Science Japan Society for the Promotion of Science Prize
- 2008 - Nara Advanced Institute for Science and Technology NAIST Award for academic achievements
- 2003 - 第一回日本分子生物学会三菱化学奨励賞
Association Membership(s) (2):
日本分子生物学会
, Molecular Biology Society of Japan
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