Research field (3)：
Pharmaceuticals - analytical and physicochemistry
, Bio-, chemical, and soft-matter physics
, Anesthesiology
Research keywords (1)：
Molecular Anesthesiology
Research theme for competitive and other funds (8)：
2015 - 2019 Study on bupivacaine enantiomer binding site of KcsA channel and its open-close modification
2009 - 2010 Molecular Mechanism of the Effect of volatile anesthetic on the Potassium Channel Kv1.5 of the Atrium.
2008 - 2010 Mechanisms of functional modification of ion channel by anesthetics
2007 - 2008 Molecular recognition of barbiturate enantiomers in agonist binding site of nicotinic acetylcholine receptor
2003 - 2004 Study on Anesthetic-protein Interactions of Model Protein of Regulator Enzyme of Channel Receptor
2002 - 2004 Electrophysiological study of the mechanism of unconsciousness of anesthesia
麻酔分子メカニズム
Mechanisms of Anesthesia
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Papers (29)：
Tomoyoshi Seto. General anesthetic binding mode via hydration with weak affinity and molecular discrimination: General anesthetic dissolution in interfacial water of the common binding site of GABAA receptor. Biophysics and physicobiology. 2023. 20. 2. e200005
Ishikawa Y, Kitagawa H, Sawada T, Seto T, Takahashi K, Yamazaki T. Deuterium Oxide Protects Against Myocardial Injury Induced by Ischemia and Reperfusion in Rats. Scan Cardiovasc J. 2019. 53. 6. 329-336
Ding W-G, Tano A, Mi X, Kojima A, Seto T, Matsuura H. Identification of verapamil binding sites within human Kv1.5 channel using mutagenesis and docking simulation. Cell Physiol Biochem. 2019. 52. 2. 302-314
Tomoyoshi Seto, Minoru Kato, Ken Koyano. Molecular Discrimination of Barbital Enantiomer at the Propofol Binding Site of the Human beta(3) Homomeric GABA(A) Receptor. CHEM-BIO INFORMATICS JOURNAL. 2018. 18. 154-163
Akiko Kojima, Yutaka Fukushima, Yuki Ito, Wei-Guang Ding, Rika Ueda, Tomoyoshi Seto, Hirotoshi Kitagawa, Hiroshi Matsuura. Interactions of propofol with human voltage-gated Kv1.5 channel determined by docking simulation and mutagenesis analyses. Journal of Cardiovascular Pharmacology. 2018. 71. 1. 10-18
瀬戸 倫義. Identification of Verapamil Binding Sites Within Human Kv1.5 Channel Using Mutagenesis and Docking Simulation. Cellular Physiology and Biochemistry. 2019. 52. 2. 302-314
Science and Technology Encyclopedia of High Pressure
Asakura Publishing CO., Ltd. 2022 ISBN:9784254102970
Structural prediction of barbital-acetylcholine receptor complex from docking simulation: In Basic and Systemic Mechanisms of Anesthesia
Elsevier B.V. 2005
Validation of Hypothesis of Pressure Reversal of Mechanisms: “Anesthetic binds to site, and squeezed out by pressure.”: In Basic and Systemic Mechanisms of Anesthesia
Elsevier B.V. 2005
Effect of heavy water on the synaptic transmission: In Basic and Systemic Mechanisms of Anesthesia
Elsevier B.V. 2005
Lectures and oral presentations (14)：
Distribution of hydration water molecule at intersubunit of a1b3g2 GABAA receptor and sevoflurane binding selectivity
(68th Annual Meeting of JSA 2021)
Characteristics of the general anesthetic binding site in the a1b3g2 GABAA Receptor
(68th Annual Meeting of JSA 2021)
Initial process of propofol binding to inter-subunit TMD of a1b3g2 GABAA receptor
(67th Annual Meeting of JSA 2020)
Systemized Safety Selection of Anesthetics for Long QT Syndrome Patient
(66th Annual Meeting of JSA 2019)
Identification of volatile anesthetic binding site of Ryanodine 1 Receptor -Mechanisms of CICR activation-
(65th Annual Meeting of JSA 2018)
