Rchr
J-GLOBAL ID：200901023785161830
Update date: Oct. 30, 2024
Fuwa Haruhiko
フワ ハルヒコ | Fuwa Haruhiko
Affiliation and department：
Job title：
Professor
Research field (4)：
Bioorganic chemistry
, Structural/physical organic chemistry
, Bioorganic chemistry
, Molecular biochemistry
Research keywords (2)：
Synthetic organic chemistry
, Natural product chemistry
Research theme for competitive and other funds (19)：
- 2022 - 2025 複雑海洋天然物の実践的全合成と構造改変による立体配座・活性制御
- 2021 - 2025 アンフィジニウム属渦鞭毛藻の有用二次代謝産物の探索と開発
- 2019 - 2020 超活性抗腫瘍性海洋天然物の全合成研究
- 2017 - 2020 Total Synthesis, Structure Determination, and Bioactive Stereostructure of Complex Macrolides
- 2018 - 2019 Total Synthesis of Complex Marine Natural Products Based on Tandem Reactions
- 2018 - 2019 Development and Application of New Synthetic Strategy toward Marine Macrolides
- 2016 - 2017 Total Synthesis, Complete Stereostructure. and Structure-Activity Relationship of Complex Macrocyclic Natural Products
- 2015 - 2017 Total Synthesis and Structure-Activity Relationship of Complex Natural Product That Exhibits Selective Cytotoxicity Against Cells Expressing Mutant c-Kit
- 2013 - 2017 Synthesis and functional analysis of novel biologically active molecules based on complex macrolide natural products
- 2014 - 2016 微量複雑海洋天然物の合理的構造単純化及び作用解析
- 2011 - 2016 Synthesis and functional analysis of ion channel selective inhibitors based on polycyclic ethers
- 2012 - 2015 実用的全合成に立脚した微量複雑海洋天然物ケミカルバイオロジー
- 2011 - 2014 Unified Total Synthesis and Structure-Activity Relationships of Marine Macrolide Natural Products of Cyanobacteria Origin
- 2011 - 2012 Mechanisms of an anti-cancer effect of a novel marine natural compound, exiguolide.
- 2009 - 2011 Total Synthesis and Functional Analysis of Complex Natural Products
- 2009 - 2010 Total synthesis of a natural HIV protease inhibitor and its partial structures
- 2007 - 2008 Development of new strategies for the synthesis of nitrogen heterocycles and its application to the search for γ-secretase inhibitors
- 2004 - 2007 グルタミン酸受容体サブタイプ選択的な生体機能分子の創製と機能解析
- 2004 - 2006 中員環ラクタムの効率的構築法の開発とそのγセクレターゼ阻害剤探索研究への応用
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Papers (165)：
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Tomohiro Obana, Miyu Nakajima, Kazuki Nakazato, Hayato Nakagawa, Keisuke Murata, Masashi Tsuda, Haruhiko Fuwa. Iriomoteolide-1a and -1b: Structure Elucidation by Integrating NMR Spectroscopic Analysis, Theoretical Calculation, and Total Synthesis. Journal of the American Chemical Society. 2024. 146. 29836-29846
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Yuki Takatori, Haruhiko Fuwa. Total Synthesis of (-)-Fasicularin. The Journal of Organic Chemistry. 2024. 89
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Haruhiko Fuwa. Total Synthesis of Marine Macrolide Natural Products by the Macrocyclization/Transannular Pyran Cyclization Strategy. SYNLETT. 2024. 35. 1488-1499
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Taisei Masuda, Kyoya Ohyama, Atushi Yoshimura, Haruhiko Fuwa. Total Synthesis of (-)-Enigmazole A by the Macrocyclization/Transannular Pyran Cyclization Strategy. Organic Letters. 2024. 26. 2045-2050
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Yuki Wada, Pavel M. Usov, Bun Chan, Makoto Mukaida, Ken Ohmori, Yoshio Ando, Haruhiko Fuwa, Hiroyoshi Ohtsu, Masaki Kawano. Atomic-resolution structure analysis inside an adaptable porous framework. Nature Communications. 2024. 15. 81
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MISC (15)：
Books (7)：
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Modern Natural Product Synthesis
Springer, Singapore 2024 ISBN:9789819716197
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Marine Natural Products (Topics in Heterocyclic Chemistry, vol. 58)
Springer, Singapore 2020
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天然有機化合物の全合成:独創的なものづくりの反応と戦略 (CSJカレントレビュー)
化学同人 2018
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Strategies and Tactics in Organic Synthesis (Vol. 12)
Elsevier 2016
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Seafood and Freshwater Toxins: Pharmacology, Physiology, and Detection, 3rd Edition
CRC Press 2014
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Lectures and oral presentations (37)：
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マクロ環化と渡環反応を基盤とするマクロリドの新合成戦略:Exiguolide の16工程全合成
(第63回天然有機化合物討論会 2021)
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複雑な海洋天然物の全合成
(有機合成化学協会関西支部有機合成夏期セミナー「明日の有機合成化学」 2019)
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タンデム反応を基盤とした新合成法の開発
(第9回有機分子構築法夏の勉強会 2019)
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変異c-kit発現細胞に選択的に作用する複雑天然物の全合成と構造活性相関解析
(公益財団法人旭硝子財団2018助成研究発表会 2018)
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Total synthesis, stereochemical revision, and biological evaluation of lyngbyaloside B, a marine macrolide glycoside
(Abstracts of PACIFICHEM2015 2015)
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Education (4)：
- 1999 - 2002 The University of Tokyo Graduate School of Science Department of Chemistry
- 1997 - 1999 The University of Tokyo Graduate School of Science Department of Chemistry
- 1993 - 1997 The University of Tokyo School of Science Department of Chemistry
- 1990 - 1993 宮城県仙台第二高等学校
Professional career (4)：
- Master of Science (The University of Tokyo)
- 修士(理学) (東京大学)
- 博士(理学) (東京大学)
- Doctor of Science (The University of Tokyo)
Work history (8)：
- 2017/04 - "Professor, Faculty of Science and Engineering, Chuo University"
- 2009/05 - 2017/03 "Associate Professor, Graduate School of Life Sciences, Tohoku University"
- 2007/04 - 2009/04 "Assistant Professor, Graduate School of Life Sciences, Tohoku University"
- 2006/07 - 2007/03 "Research Associate, Graduate School of Life Sciences, Tohoku University"
- 2005/04 - 2006/06 "Postdoctoral Fellow, JSPS"
- 2005/02 - 2005/03 "Research Staff, Graduate School of Life Sciences, Tohoku University"
- 2002/10 - 2005/01 "Research Associate, Graduate School of Pharmaceutical Sciences, The University of Tokyo"
- 2001/04 - 2002/09 "Research Fellow, JSPS"
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Committee career (6)：
Awards (5)：
- 2011/04 - 文部科学省 科学技術分野の文部科学大臣表彰若手科学者賞 海洋天然有機化合物の高効率的全合成の研究
- 2010/03 - 日本化学会 日本化学会第59回進歩賞 複雑な構造を有する海洋天然有機化合物の効率的全合成
- 2008/10 - 天然有機化合物討論会 第50回天然有機化合物討論会奨励賞(ポスター発表の部) 鈴木-宮浦カップリング反応を基盤とする天然物全合成
- 2004/07 - 天然物化学談話会 第4回天然物化学談話会奨励賞 海産毒ガンビエロール全合成と多様性志向型全合成による構造活性相関
- 2002/10 - 天然有機化合物討論会 第44回天然有機化合物討論会奨励賞(口頭発表の部) ガンビエロールの全合成
Association Membership(s) (4)：
日本薬学会
, 日本化学会
, 有機合成化学協会
, 日本ケミカルバイオロジー学会
