NAGAO Shizuko

ナガオシズコ | NAGAO Shizuko

Affiliation and department：
Homepage URL (1)： http://www.fujita-hu.ac.jp/CAMHD/LAS2020/

Research field (6)： Experimental pathology , Genetics , Nephrology , Laboratory animal science , Pharmacology , Pathobiochemistry

Research keywords (10)： polycystic kidney disease , diabetic kidney disease , chronic kidney disease , disease model , genome editing , Cell proliferation , inflammation , second messenger , cAMP , cell signalling pathway

Research theme for competitive and other funds (21)：

2022 - 2025 キヌレニン/キヌレン酸を標的とした多発性嚢胞腎症における新規治療薬の開発
2021 - 2024 Significance of rare nucleotide sugar in of cell proliferation of cystic kidney disease
2021 - 2024 摂取カロリー同等/PFCバランス不同食の糖尿病性腎臓病と認知機能障害に及ぼす影響
2020 - 2023 Establichment of control method for M2-type activated macrophage-mediated progression of childhood CKD.
2020 - 2023 The study for the role of tryptophan metabolism in diabetic nephropathy-associated cognitive disorder

2019 - 2022 Elucidation of the role of tryptophan metabolism in diabetic nephropathy: Towards a development of novel treatment of diabetic nephropathy targeting tryptophan metabolism

2018 - 2021 Research on the key factors and signal transduction cascades of the onset of chronic kidney disease (CKD): Application of global omics technologies.

2017 - 2019 Evaluation of the postmortem lung change using rat euthanasia model and small animal X-ray CT

2016 - 2019 Ameriolation of progression of polycystic kidney disease by stabilization of renal vessel disorders and exploration of endogenous retrovirus responses in macrophages

2015 - 2018 Omics analysis applicable to preemptive medicine of chronic kidney disease -focusing on comprehensive analysis of phosphorylated proteins-

2013 - 2016 Creation of a novel device for renal regeneration by the interaction of a nonwoven filters and cells.

2012 - 2015 A study of molecular pathogenesis of chronic pancreatitis by using polycystic kidney rat

2012 - 2015 Basic studies of therapeutic modality for polycystic kidney disease explored by epigenetic modification of cellular matrix-adhesion proteins

2010 - 2012 A novel therapeutic approach for cystic disease:Inhibition of intracellular signal transduction pathways by a nuclear receptor cascade

2010 - 2012 The clarify of the mechanism of induction of immunological tolerance using mouse liver transplantation model and development of novel immunosuppression.

2009 - 2011 Mechanisms for Ca2+ absorption by pancreatic ductal epithelium : A study looking for a new strategy to prevent pancreatic stone formation.

2004 - 2006 Molecular pathogenesis of chronic pancreatitis: CFTR and intraductal sensor molecules

1996 - 1996 嚢胞腎モデルにおける細胞増殖抑制剤の治療効果の検討による細胞増殖と細胞の死の解析

1995 - 1995 2つの嚢胞腎モデルにおける細胞増殖抑制剤,Taxol,の治療効果の検討

1992 - 1992 腎臓における新しいDNA結合蛋白質の局在性-正常腎及び疾患腎について-

1990 - 1992 Study of the pathogenesis of progressive hereditary PKD mouse

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Papers (119)：

Yoshiki Kawamura, Satoshi Komoto, Saori Fukuda, Masanori Kugita, Shuang Tang, Amita Patel, Julianna R Pieknik, Shizuko Nagao, Koki Taniguchi, Philip R Krause, et al. Development of recombinant rotavirus carrying herpes simplex virus 2 glycoprotein D gene based on reverse genetics technology. Microbiology and immunology. 2024. 68. 2. 56-64
Takahiro Matsuyama, Seiichiro Ota, Yoshitaka Inui, Naoko Fujii, Tetsuya Tsukamoto, Ichiro Isobe, Katsumi Tsujioka, Shizuko Nagao, Ryosuke Tanabe, Hiroshi Toyama. Examination of postmortem changes in the lungs, trachea, and bronchi in a rat model imaged with small-animal computed tomography. Fujita medical journal. 2023. 9. 2. 101-104
Hisayoshi Kubota, Kazuo Kunisawa, Bolati Wulaer, Masaya Hasegawa, Hitomi Kurahashi, Takatoshi Sakata, Hiroyuki Tezuka, Masanori Kugita, Shizuko Nagao, Taku Nagai, et al. High salt induces cognitive impairment via the interaction of angiotensin II-AT1 and prostaglandin E2-EP1 systems. British journal of pharmacology. 2023. 180. 18. 2393-2411
Shizuko Nagao, Tamio Yamaguchi. Review of the Use of Animal Models of Human Polycystic Kidney Disease for the Evaluation of Experimental Therapeutic Modalities. Journal of clinical medicine. 2023. 12. 2
Sei Saitoh, Takashi Takaki, Kazuki Nakajima, Bao Wo, Hiroshi Terashima, Satoshi Shimo, Huy Bang Nguyen, Truc Quynh Thai, Kanako Kumamoto, Kazuo Kunisawa, et al. Treatment of tubular damage in high-fat-diet-fed obese mice using sodium-glucose co-transporter inhibitors. PloS one. 2023. 18. 2. e0281770

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MISC (171)：

白水貴大, 吉村文, 坂田美和, 熊本海生航, 釘田雅則, 高橋和男, 長尾静子. 食塩誘導性高血圧により糖尿病性腎症を発症した肥満2型糖尿病モデルSDT fattyラットへのエナラプリル投与実験. 日本腎臓学会誌. 2023. 65. 3. 317-317
後田ちひろ, 亀井優香, 今度匡祐, 土田宏美, 清野祐介, 長尾静子, 矢部大介, 鈴木敦詞, 飯塚勝美. インスリン抵抗性状態ではChREBP活性は減弱する. 糖尿病. 2023. 66. Suppl.1. S-183
釘田雅則, 亀井優香, 坂田美和, 熊本海生航, 吉村文, 白水貴大, 長尾静子. 多発性嚢胞腎症患者の遺伝子変異に基づく新規モデルマウスの作成. 日本実験動物学会総会講演要旨集(Web). 2023. 70th
吉村文, 白水貴大, 坂田美和, 釘田雅則, 熊本海生航, 長尾静子. PCKラットにおけるRAS阻害薬の組織保護作用. 日本実験動物学会総会講演要旨集(Web). 2023. 70th
河野春奈, 西尾妙織, 長船健二, 日高寿美, 山口太美雄, 花岡一成, 星野純一, 長尾静子, 奴田原紀久雄, 土谷健, et al. 嚢胞腎協会設立の歩みと展望. 日本腎臓学会誌. 2022. 64. 6-E. 601-601

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Patents (2)：

Books (5)：

Annual Review 2013腎臓(冨野康日己、柏原直樹、成田一衛編)
中外医学社、東京 2013
多発性嚢胞腎のすべて(東原英二編)
インターメディカ、東京 2006
Annual Review 2003 腎臓(伊藤克己、浅野泰、遠藤仁、御手洗哲也、東原英二編)
中外医学社、東京 2003
バイオメディカルリサーチマニュアル VI疾患モデル動物(笠井憲雪、板垣慎一編)
養賢堂、東京 1995
[疾患別] モデル動物の作製と新薬開発のための試験・実験法-薬理・薬効評価と安全性試験への応用(内貴正治編)
技術情報協会、東京 1993

Lectures and oral presentations (221)：

メカニズムから迫る、PKDへのアプローチ基礎研究の進歩 -Annual review: Studies using PKD model animals over the past year-
(第1回PKDカンファレンス2023 2023)
ARPKDモデル動物における食塩感受性高血圧が及ぼす腎髄質と皮質における嚢胞形成機序の違い
(第1回PKDカンファレンス2023 2023)
Comparative Transcriptome Analysis of Spontaneously Diabetic Torii Fatty Rat Undergoing Salt Loading Alone or with Unilateral Nephrectomy
(Week 2023 Annual Meeting 2023)
Sox2/CD63-GFP transgenic rat: A novel model for nephrogenic diabetes insipidus
(Kidney Week 2023 Annual Meeting 2023)
Exploring progression factors of nephropathy in an obesity-associated type 2 diabetes rat model
(University of Manitoba, Canadian Centre for Agri-Food Research in Health and Medicine Seminar 2023)

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Professional career (1)：

博士(医学)

Work history (4)：

2012/10 - 現在 Fujita Health University Graduate school Professor
2012/10 - 現在 Fujita Health University Advanced Medical Research Center for Animal Model of Human Diseases Professor
2008/04 - 現在 Fujita Health University Advanced Medical Research Center for Animal Model of Human Diseases
1998/09 - 2000/08 U.S.A. University of Kansas Medical Center Kidney Institute Visiting Assistant Professor

Awards (3)：

2016/09 - The Asian Pacific Society of Nephrology Young Investigator Award Mitochondrial dysfunction contributes to cyst proliferation of autosomal dominant polycystic kidney disease.
2012/06 - 第55回日本腎臓学会総会優秀演題賞ラット多発性嚢胞腎におけるPPARγ アゴニスト投与の治療考課に関する網羅的遺伝子発現プロファイリング
2011/06 - 第54回日本腎臓学会総会優秀演題賞ヒト多発性嚢胞腎症のラットモデルにおけるPPAR-gammaアゴニストの治療効果

Association Membership(s) (14)：

藤田学園医学会 , 日本栄養改善学会 , 日本膵臓学会 , 日本分子生物学会 , 米国生理学会 , 日本実験動物学会 , 米国実験動物学会 , 日本小児腎臓学会 , 日本腎臓学会 , 米国腎臓学会 , 国際腎臓学会 , 東海実験動物研究会 , 囊胞性腎疾患研究会 , 公私立大学実験動物施設協議会

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