- 2023 - 2026 Elucidation of the mechanism of myocardial energy metabolism regulation by NC compound, a KLF5 inhibitor with a beneficial effect on heart failure.
- 2020 - 2023 臨床ビッグデータとトランスオミックス解析を統合した新しい心臓病学パラダイム構築
- 2019 - 2023 The mechanism of the transformation of smooth muscle cells in familial thoracic aortic aneurysm and dissection (FTAAD) of point mutation of myosin heavy chain, Myh11,
- 2019 - 2023 癌を選択的に抑制しかつ心機能を改善するKLF5阻害薬の開発とその分子作用機序解明
- 2018 - 2023 新しい心不全治療薬としての新規PDK4阻害薬の開発
- 2018 - 2023 Molecular mechanism of vascular aging and heart failure due to transcription and DNA damage response and therapeutic application
- 2018 - 2021 The pathophysiological mechanisms and causative genetic mutations of familial aortic aneusyrm/dissection and patent ductus arteriosus
- 2018 - 2021 Molecular mechanism of familial aortic dissection by smooth muscle myosin mutation and elucidation of vascular aging mechanism
- 2015 - 2019 Elucidation of molecular mechanism and treatment application of heart failure by transcription factor and DNA damage response factor
- 2015 - 2018 Protein complex analysis of transcriptional factor KLF, and development of a low molecular weight compound that inhibits KLF5 transcriptional activity.
- 2015 - 2016 Improvement of the PDK4 inhibitors based on the tertiary structure analysis and application for the treatment of heart failure
- 2010 - 2015 KLF network in chronic diseases and cancer
- 2009 - 2011 Identification of the molecule binding with the cardiac transcriptional regulator HOP and analysis on the molecular function of heart failure
- 2010 - 2010 KLF5ネットワークによる心血管・腎・代謝疾患の病態分子機構の解明と治療展開
- 2009 - 2009 心血管代謝疾患における単球・マクロファージの新機能の解明と治療法への応用
- 2007 - 2009 Molecular mechanisms that control stress response and tissue remodeling by cardiometabolic and immune systems
- 2005 - 2009 The systematic analysis on the diseases through the integration of the clinical data with the genomic information
- 2008 - 2008 マクロファージニッチによる心血管代謝疾患発症機構の解明と治療法開発
- 2007 - 2008 The Role of Internal Biological Clock in the Cardiovascular Diseases and the Development of New Therapeutic Strategy
- 2007 - 2007 上皮間葉移行(EMT)による心血管リモデリングの分子機構解明
- 2006 - 2007 Transcription factor networks in blood vessel-metabolic system crosstalk and metabolic syndrome
- 2006 - 2006 血管新生制御による肥満・メタボリックシンドローム治療法の開発
- 2005 - 2006 Construction of Clinical Trail Designs Database and Development of Security System for Personal Information Protection
- 2002 - 2006 Molecular mechanism of organ remodeling : Gene transcription and cell-cell interaction in mesenchymal
- 2004 - 2005 新規転写因子KLF5による骨代謝調節機構の解明
- 2004 - 2005 siRNAによる心血管疾患・慢性炎症性疾患治療法開発
- 2004 - 2005 Investigation of molecular mechanism in the development of chronic obstructive pulmonary disease (COPD) and susceptibility to cigarette smoke-induced lung injury using transgenic animal models.
- 2004 - 2005 Transcriptional regulation and signaling in the interaction between vascular cells and adipocytes in metabolic syndrome
- 2003 - 2005 Development of the way how to induce efficient cardiomyocyte differentiation using stem cells and attempt for cell transplantation therapy against heart failure
- 2003 - 2004 Development of new treatment modalities for age-related macular degeneration
- 2002 - 2003 心血管特異的薬剤誘導型遺伝子改変マウスの開発
- 2002 - 2003 Hereditary Abnormalities of Multiple Risk Factors for Atherosclerosis ; Role of Endothelial Dysfunction and Aortic CD36 Expression in Diabetic Hyperlipidemic Rats
- 2002 - 2003 Investigation of molecular mechanism in the development of chronic obstructive pulmonary disease (COPD) using transgenic animal models.
- 2002 - 2003 Molecular mechanisms of circadian oscillation of cardiovascular function regulated by the internal biological clock
- 2001 - 2003 Analysis of molecular mechanism in cardiomyocyte differentiation and its application for regeneration medicine using embryonic stem cells
- 2000 - 2002 Involvement of the aging-suppressor gene klotho in the skeletal
- 2000 - 2002 心血管系の負荷応答と病態形成:遺伝子転写シグナルと病態生理に基づく治療戦略の確立
- 2000 - 2002 Estimation of Susceptibility to and Prognosis of Cardiovascular Diseases Based on Genetic Polymorphism and Its Application to Drug Discoveries
- 2001 - 2001 心血管系機能日内変動の分子生物学的、遺伝学的メカニズムの解明
- 2001 - 2001 IT技術を駆使した外来予約及びデータ管理システムの開発-臨床医学研究への新展開
- 1999 - 2001 The role of Klotho in allograft vascular disease
- 1999 - 2001 Development of inhibitors for the activation of cardiovascular interstitial ceils
- 1997 - 2001 動脈硬化の分子機構
- 2000 - 2000 血管の発生分化と病態形成
- 2000 - 2000 腹腔内異物周囲に形成される肉芽組織を用いた自己血管再生法の開発
- 1999 - 2000 Transcriptional regulation of the SERCA2 gene during the development of heart failure
- 1999 - 2000 Klotho gene product may have a role to regulate VEGF and p21 and tightly linked to the endothelial function to release NO
- 1999 - 2000 平滑筋免疫シンチグラフィによる大動脈解離の新しい画像診断法の臨床応用
- 1998 - 2000 Development of intracellular therapy to induce a regression of coronary arteriosclerotic lesions
- 1997 - 2000 Molecular mechanisms of phenotypic modulation and growth of smooth muscle cells
- 1999 - 1999 血管病変を形成する平滑筋細胞の起源の解明
- 1998 - 1999 Klotho欠損マウスにおける心筋細胞の分化異常に関する研究
- 1998 - 1999 転写因子による血管新生とその抑制の分子機構の解明
- 1997 - 1998 STUDY OF ABNORMAL GLUCOSE METABOLISM ASSOCIATED WITH AGEING AND ESTABLISHMENT FOR AN ANIMAL MODEL OF NIDDM
- 1997 - 1998 Endothelial Function and Arteriosclerosis in Klotho Mouse
- 1997 - 1998 Development of immunoscintigraphy using radiolabeled murine anti-smooth muscle myosin monoclonal antibody for diagnostic imaging of acute bowel infarction-application of immunoscintigraphy for smooth muscle affecting disease-
- 1997 - 1998 Changes in responses to ischemic attack associated with ageing : analyses by a new mouse model which shows a syndrome resembling ageing
- 1997 - 1998 Skeletal muscle deoxygenation during exercise in diabetics Medecine
- 1997 - 1998 Physiological function of ageing suppression gene klotho and its role in development of adult disease
- 1997 - 1998 Molecular mechanisms of vascular aging : analysis of a newly developed aging mouse
- 1996 - 1998 Development of therapeutic methods for arterial restenosis : intraarterial radiation, pharmaceutical approach and gene therapy
- 1997 - 1997 血管内皮細胞障害におけるNa/H逆輸送担体活性化の意義と拮抗薬による治療法の開発
- 1995 - 1997 心血管系への遺伝子デリバリーシステムの開発と遺伝子治療への応用
- 1996 - 1996 老化におけるフリーラジカルの役割:新しい老化モデル動物を用いた検討
- 1996 - 1996 抗平滑筋ミオシン抗体シンチグラフィによる解離性大動脈瘤の画像診断法の開発
- 1996 - 1996 血管の老化と平滑筋増殖を制御する遺伝子の同定
- 1996 - 1996 動脈硬化の分子機構
- 1996 - 1996 心筋細胞の文化異常と病態形式
- 1994 - 1996 STUDIES ON BUILT-ENVIRONMENT OF PATIENTS' ROOM AND BEDSIDE IN TERMS OF MEDICAL ACTIVITIES AND PATIENTS' PHYSIOLOGICAL FUNCTION.
- 1994 - 1995 ESTABLISHMENT OF MICE DEFICTENT IN A VASOACTIVE PEPTIDE BY GENE TARGETING AND THEIR APPLICATION TO PATHOPHYSIOLOGICAL ANALYSIS
- 1994 - 1995 Pathogenesis and molecular mechanisms of arteral restenosis
- 1993 - 1995 Development of new diagnostic and therapeutic methods and animal models of cardiovascular diseases using smooth muscle myosin heavy chain isoforms.
- 1993 - 1995 The elucidation of the roles of cell-adhesion molecules in heart diseases
- 1994 - 1994 心筋虚血再灌流障害の細胞内・細胞間分子機構の解明とそれに基づいた予防法の確立
- 1993 - 1994 The phenotypic modulation in renal arteriolar smooth muscles and the glomerular mesangial cells.
- 1993 - 1994 Application of gene targeting to the study of atherosclerosis
- 1993 - 1994 Cardio-Specific Gene Expression and Genetic Analysis of Myocardial Disorders
- 1993 - 1993 平滑筋細胞における平滑筋型と非筋細胞型ミオシン重鎖の遺伝子発現制御機構
- 1993 - 1993 心筋虚血再潅流障害の分子機構の解明および接着分子タンパクを用いた予防法の確立
- 1991 - 1993 Analysis of abnormal differentiation of smooth muscles in arterial lesions and an in vitro trial to induce smooth muscle cell differentiation
- 1992 - 1992 血管平滑筋の分化制御と血管機能異常における意義
- 1991 - 1992 Intracellular Signaling of Stretch Mediated Myocyte Growth
- 1990 - 1992 Diffcrential diagnosis of tuberculosis and nontuberculous infectious diseases by PCR-RFLP and sequence-specific oligonucleotide probes
- 1991 - 1991 血管平滑筋で発現するPDGF-A鎖とNa-H逆輸送担体の分子機能解析
- 1991 - 1991 負荷に対する心筋の細胞内応答機構の分子生物学的解析ーイオン移送系を中心に
- 1990 - 1990 動脈硬化の発生と平滑筋細胞の分化異常に関する研究平滑筋動ミオシン重鎖アイソフォ-ムとPDGFーA鎖アイソフォ-ムを示標とした検討
- 1989 - 1989 血管平滑筋ミオシン重鎖のアイソフォ-ムとその発現に関する研究
- 1989 - 1989 遺伝子増幅法を用いたウィルス性心筋炎の診断
- 1989 - 1989 腎における尿酸輸送担体のクロ-ニングとその解析
- 転写因子KLF5による心血管・代謝疾患の病態解明と治療法の開発
- molecular mechanisms of cardiovascular diseases
Show all
