Research field (6):
Neuroscience - general
, Pathobiochemistry
, Experimental pathology
, Medical biochemistry
, Hematology and oncology
, Molecular biology
Research theme for competitive and other funds (18):
2020 - 2023 Txnipを応用した乳癌層別診断法の開発とRNA制御機構の解明
2017 - 2020 Txnipリボヌクレオプロテイン複合体による代謝制御・癌抑制
2015 - 2015 Txnip誘導阻害化合物による糖代謝改善薬の開発
2013 - 2015 Elucidation of the molecular mechanism of insulin resistance by investigating TBP-2/Txnip and chemical biology
2011 - 2013 Establishment of a next generation cell therapy for diabetes based on Thioredoxin and C5a inhibitory peptide
2011 - 2012 アルファアレスチンによる絶食応答・脂肪蓄積制御
2008 - 2009 レドックス制御分子による癌細胞の増殖・死の調節機構の研究
2005 - 2006 Analysis of the mechanism and biological function of the internalization of thioredoxin into cells via lipid raft.
2004 - 2005 Effect of oxidative stress and redox-regulating proteins on tumor growth and chemosensitivity
2003 - 2005 The study on the regulation of cellular growth and aging process by thioredoxin binding protein
2001 - 2002 Investigation of biological function of thioredoxin by construction of thioredoxin knock down mice
2001 - 2001 チオレドキシンシステムのプロテオーム解析による感染宿主応答分子機構の研究
1998 - 1999 ANALYSIS OF OXIDATIVE STRESS INDUCED APOPTOSIS MECHANISM AND THE BINDING PROTEINS TO THE OXIDATIVE RESPONSIVE ELEMENT
1997 - 1998 ANALYSIS AND ITS CLINICAL APPLICATION OF REDOX REGULATION MECHANISM FOR SURGICAL STRESS
thioredoxin binding protein-2(TBP-2の研究)
ストレスシグナリングとレドックス制御機構
Study of thioredoxin binding protein-2 (TBP-2)
Stress Signaling and Redox regulation
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Papers (175):
Eiji Yoshihara, Yoshiyuki Matsuo, So Masaki, Zhe Chen, Hai Tian, Hiroshi Masutani, Akira Yamauchi, Kiichi Hirota, Junji Yodoi. Redoxisome Update: TRX and TXNIP/TBP2-Dependent Regulation of NLRP-1/NLRP-3 Inflammasome. Antioxidants & redox signaling. 2024. 40. 10-12. 595-597
Zou Meng, 田部 勝也, 椎木 幾久子, 河野 大輔, 田口 昭彦, 奥屋 茂, 北村 忠弘, 増谷 弘, 谷澤 幸生. Txnipはマウスにおいて先天性BAT熱産生機能を維持する(Txnip preserves innate BAT thermogenic function in mice). 糖尿病. 2023. 66. Suppl.1. S-302
Masutani H. Thioredoxin interacting protein in cancer and diabetes. Antioxid Redox Signal. 2021
Mina Noura, Hidemasa Matsuo, Asami Koyama, Souichi Adachi, Hiroshi Masutani. TXNIP induces growth arrest and enhances ABT263-induced apoptosis in mixed-lineage leukemia-rearranged acute myeloid leukemia cells. FEBS Open Bio. 2020. 10. 8. 1532-1541
Tomonori Soyama, Hiroshi Masutani, Cristiane Lumi Hirata, Eri Iwai-Kanai, Takashi Inamoto. Thioredoxin as a novel sensitive marker of biological stress response in smoking. Journal of Clinical Biochemistry and Nutrition. 2020. 67. 3
Regulation of gene expression and transcription factors in response to environmental oxidants. In ′′environmental stressors : Effects on Lung, Skin, Eye and Immune System Function′′ edited by J(]E88DB[)rgen FUCHS and Lester PACKER
Marcel Dekker Inc. New York. 2001
Environmental Stressors in Health and Disease
Marcel Dekker 2001
Thioredoxin-dependent redox regulation in biological responses. In" Free Radicals in Chemistry, Biology and Medicine" edited by
Y. OICA International, London 2000
Thioredoxin interacting protein (Txnip) forms high molecular weight ribonucleoprotein complexes in cancer cells
(THe 27th Annual Meeting of the Japanese Society for Cell Death Research 2018)
Development of drugs against anti-diabetes and recognition disorders based on Txnip
(2018)
Thioredoxin interacting protein (Txnip) High order complex formation in cancer cells
(2017)
SFRR Japan
, 日本内科学会
, 日本分子生物学会
, 日本生化学会
, 日本癌学会
, SFRR Japan
, Japanese internal medicine society
, Japanese molecular biology association
, Japanese Biochemical Association
, Japanese Cancer Association