Mitsui Kaoru

ミツイカオル | Mitsui Kaoru

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： http://www.kufm.kagoshima-u.ac.jp/~anatomy2/

Research field (4)： Anatomy , Molecular biology , Cell biology , Developmental biology

Research keywords (6)：ウイルスベクター , iPS細胞 , 胚性幹細胞 , virus vector , induced pluripotent stem cells , Embryonic Stem Cells

Research theme for competitive and other funds (26)：

2023 - 2026 浸潤・転移の骨軟部肉腫を治療可能な革新的な腫瘍溶解性ウイルス・免疫治療法の創出
2022 - 2025 免疫チェックポイントBispecific抗体遺伝子発現・腫瘍溶解性ウイルスの創出
2022 - 2025 免疫チェックポイント阻害抗体遺伝子を発現する腫瘍溶解性ウイルスの開発
2022 - 2025 Establishment of a method for myocardial differentiation conversion using myocardial differentiation-specific miRNAs and elucidation of the regulatory mechanism of myocardial differentiation
2020 - 2023 増殖型ウイルス/CAR-T融合による革新的な癌免疫遺伝子・細胞治療技術の創出

2020 - 2023 骨軟部腫瘍を制圧できる全身性癌免疫誘導の革新的な免疫遺伝子・ウイルス治療の開発

2019 - 2023 Establishment of efficient myocardial direct reprogramming method using miRNA and elucidation of its molecular basis.

2017 - 2020 Development of Innovative Gene-Virus Therapy for Tumor Lysis, Immunity Induction, and Cancer Stem Cell Suppression in Bone and Soft Tissue Sarcoma.

2014 - 2018 A study of osteoblast differentiation and osteogenesis in transcription factor Msx2-transfer human iPS cells

2016 - 2017 ES/iPS細胞由来遺伝子改変破骨細胞によるBRONJ治療法の開発

2013 - 2017 Molecular elucidation of normal and cancer stem cells towards development of innovative m-CRA therapy for pediatric cancer

2013 - 2016 The development of the novel vector that eliminates ES/iPS cell-derived tumor to realize regenerative medicine

2011 - 2013 A study of osteoblast differentiation and activation in Msx2 gene-transfer ES/iPS cells.

2012 - 2012 A novel method for identification and isolation of human pluripotent stem cell-derived target cells and elimination of tumorigenic cells.

2010 - 2012 The development of conditionally replicating adenovirus targeting cancer stem cell for innovative treatment for pediatric cancer

2009 - 2010 Roles of Msx2 in osteoblast proliferation, differentiation and activation for bone remodeling.

2008 - 2009 野生型マウス由来体細胞からの誘導性多能性幹細胞(iPS細胞)の樹立

2008 - 2009 Induced pluripotent stem cells generated without viral integration.

2005 - 2009 The mechanism of somite segmentation with periodic patterning

2005 - 2006 始原生殖細胞の形成直後に発現するnanos3の機能解析

2006 - ウイルスベクターを用いた相同組換えによるヒトES細胞の染色体操作法の開発と研究用モデル細胞の創製

2003 - 2004 胚性幹細胞で特異的に発現するホメオボックス遺伝子ECAT4の機能解明

2002 - 2003 翻訳調節因子NAT1の初期発生における役割の解明

2002 - 2003 ES細胞の増殖から分化への切り換えにおける翻訳調節因子NAT1の役割

2002 - 2002 eIF4G関連蛋白質NAT1の機能解明

2002 - 2002 翻訳調節因子NAT1の細胞増殖と分化における役割

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Papers (24)：

Hirotaka Kawakami, Nobuhiro Ijichi, Yuki Obama, Eriko Matsuda, Kaoru Mitsui, Yuya Nishikawaji, Maki Watanabe, Satoshi Nagano, Noboru Taniguchi, Setsuro Komiya, et al. An optimal promoter regulating cytokine transgene expression is crucial for safe and effective oncolytic virus immunotherapy. Translational research : the journal of laboratory and clinical medicine. 2024. 273. 32-45
Kaoru Mitsui, Tomoyuki Takahashi, Kanako Ide, Eriko Matsuda, Ken-ichiro Kosai. Optimization of adenoviral gene transfer in human pluripotent stem cells. Biochemical and Biophysical Research Communications. 2021. 541. 78-83
Ide K, Mitsui K, Irie R, Matsushita Y, Ijichi N, Toyodome S, Kosai KI. A Novel Construction of Lentiviral Vectors for Eliminating Tumorigenic Cells from Pluripotent Stem Cells. Stem cells (Dayton, Ohio). 2018. 36. 2. 230-239
三井薫, 井手佳菜子, 豊留宗一郎, 小戝健一郎. 多発性幹細胞由来腫瘍を直接殺傷除去する革新的なウイルスベクター技術の開発. 第35回日本ヒト細胞学会学術総会. 2017
Kaoru Mitsui, Kanako Ide, Tomoyuki Takahashi, Ken-ichiro Kosai. Viral Vector-Based Innovative Approaches to Directly Abolishing Tumorigenic Pluripotent Stem Cells for Safer Regenerative Medicine. MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT. 2017. 5. 51-58

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MISC (21)：

Ken-ichiro Kosai, Kanako Ide, Kaoru Mitsui. A Novel Construction of Lentiviral Vectors for Eliminating Tumorigenic Pluripotent Stem Cells. MOLECULAR THERAPY. 2017. 25. 5. 70-70
Kanako Ide, Kaoru Mitsui, Ken-ichiro Kosai. An Efficient Construction of Lentiviral Vectors That Identify and Eliminate Tumorigenic Cells in Pluripotent Stem Cells. MOLECULAR THERAPY. 2016. 24. S94-S95
Hisashi Sahara, Shiori Waki, Kaoru Mitsui, Mitsuhiro Sekijima, Takehiro Iwanaga, Yurika Ichinari, Kenichiro Kosai, Kazuhiko Yamada. Establishment of feeder free culture of naive state of porcine iPS cells. XENOTRANSPLANTATION. 2015. 22. S44-S44
Hisashi Sahara, Shiori Waki, Kaoru Mitsui, Mitsuhiro Seki-jima, Takehiro Iwanaga, Yurika Ichinari, Kenichiro Kosai, Kazuhiko Yamada. ESTABLISHMENT OF FEEDER FREE CULTURE OF NAIVE STATE OF PORCINE IPS CELLS. TRANSPLANTATION. 2015. 99. 11. S71-S71
三井薫, 井手佳菜子, 高山明子, 小戝健一郎. 増殖型アデノウイルスベクターを用いた安全なヒトES/iPS細胞治療の開発. 再生医療. 2012. 11. 166

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Books (1)：

iPS細胞の安全・高品質な作製技術
技術情報協会 2016

Education (3)：

- 2000 Kurume University
- 1996 University of Tsukuba Master's Program in Biosystem Studies
- 1994 University of Yamanashi Graduate Faculty of Interdisciplinary Research Faculty of Education Education (Childhood developmental education)

Professional career (1)：

博士(医学) (久留米大学)

Work history (6)：

2019/01 - 現在 Kagoshima University Graduate School of Medical and Dental Sciences Associate Professor
2009/07 - 2018/12 Kagoshima University Graduate School of Medical and Dental Sciences Lecturer
2006 - 2009 Saitama Medical University Faculty of Medicine
2003 - 2006 National Institute of Genetics
2005 - University of Yamanashi

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