Rchr
J-GLOBAL ID：200901025340941870
Update date: Sep. 11, 2024
Kitamura Daisuke
キタムラ ダイスケ | Kitamura Daisuke
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
https://dai3kitamura.jimdofree.com
Research field (1)：
Immunology
Research keywords (1)：
B-cell development and immune response
Research theme for competitive and other funds (44)：
- 2021 - 2024 Elucidation of spatiotemporal control mechanism of dead cell DNA degrading enzymes by phase separation
- 2020 - 2023 Mechanisms for induction and regulation of memory B cell subsets exhibiting distinct recall responses
- 2020 - 2023 A study of pathogenic B-cell memory function and its regulation using an autoimmune IgA nephropathy mouse model
- 2019 - 2021 Identification of neoself antigens that tumor-infiltrating B cells present
- 2018 - 2020 Mechanisms for de-tolerance spreading of B cells in autoimmune diseases
- 2017 - 2019 Identification of neo-self tumor antigens recognized by tumor-infiltrating B cells.
- 2016 - 2019 Functional analysis of memory B cells as the effector cells
- 2016 - 2018 Regulation of B-cell memory formation by metabolic programs
- 2014 - 2016 Mechanisms for the acquisition of somatic hypermutation activity during the late B cell development
- 2013 - 2016 A study of the regulational mechanisms for IgE+ B cell development and maintenance
- 2013 - 2015 胚中心B細胞から記憶B細胞への運命決定機構
- 2013 - 2015 二次リンパ組織において記憶B細胞の時空間的制御を担う支持細胞の同定
- 2012 - 2014 Molecular analyses of B-cell memory development through synthetic immunology
- 2010 - 2012 Molecular mechanisms for affinity-based selection, development and maintenance of memory B cells.
- 2010 - 2011 胚中心におけるB細胞の自己識別および寛容誘導の分子機構
- 2009 - 2010 抗原受容体のエンドサイトーシスとシグナル伝達の相互制御機構の解明
- 2008 - 2009 胚中心におけるB細胞の自己識別および寛容誘導の分子機構
- 2007 - 2008 Regulation of B-cell proliferation and differentiation by reorganization of receptor-signal transduction machinery.
- 2006 - 2007 プレB細胞受容体シグナル伝達異常による白血病の多段階発がん機構
- 2005 - 2006 抗原受容体シグナル制御による免疫記憶の増強
- 2004 - 2004 抗原受容体シグナル制御による免疫記憶の増強
- 2002 - 2004 Signal Regulation Mechanisms for B Cell Development and Self-Tolerance Establishment.
- 2002 - 2004 Corss-talk of signals between immunoreceptors and cytokine receptors for development of allergy
- 2002 - 2002 宿主B細胞を利用したHIV-1遺伝子高頻度突然変異誘導機構
- 2000 - 2002 B細胞分化・多様化を制御する抗原受容体シグナルにおけるBASH/BLNKの役割
- 2001 - 2001 宿主B細胞を利用したHIV-1遺伝子高頻度突然変異誘導機構
- 1999 - 2001 Regulation of development of type I allergy by the signal transducer specific for the high-affinity IgE receptor
- 2000 - 2000 B細胞分化・多様化を制御する抗原受容体シグナルにおけるBASH/BLNKの役割
- 1998 - 2000 Analysis of B-cell antigen receptor signal regulation and dys-regulation emerged as autoimmune diseases
- 1998 - 1998 肝臓型マラリア原虫感染に対する免疫応答機構の解析
- 1997 - 1998 Study of CDK inhibitors in B cell immune response
- 1996 - 1996 標的遺伝子組換えによる変異マウスを用いたリンパ球シグナル伝達の研究
- 1995 - 1995 標的遺伝子組換えによる変異マウスを用いたB細胞シグナル伝達の研究
- 1994 - 1995 A study of BP1 function in lymphocyte development through a generation of BP1-gene knock-out mice.
- 1994 - 1995 Analysis of the signal transducing mechanism which leads to the antigenspecific activation or cell death of the lymphocytes.
- 1993 - 1995 Functional analysis of infiltrating lymphocytes in islets of NODmice by using gene targeting.
- 1994 - 1994 遺伝子導入動物による発癌の研究
- 1994 - 1994 標的遺伝子組換えによる変異マウスを用いたB細胞シグナル伝達の研究
- 1993 - 1993 標的遺伝子組換えによる変異マウスの作製とこれを用いたB細胞シグナル伝達の研究
- 1992 - 1993 Research on the B cell development using mutant mice generated through gene targeting.
- 1992 - 1993 Research on the regulatory mechanism of immunoglobulin gene expression and recombination by means of gene targeting.
- 1991 - 1992 Identification of Transcriptional Factor(s) which regulates Ig gene expression
- リンパ球分化・活性化・がん化を制御するシグナル伝達機構の研究
- Molecular mechanisms of receptor signal transduction regulating lymphocyte development, activation and oncogenesis.
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Papers (148)：
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Yoshihito Nihei, Daisuke Kitamura. Pathogenesis of IgA nephropathy as a tissue-specific autoimmune disease. International Immunology. 2024
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Higashiyama M, Haniuda K, Nihei Y, Kazuno S, Kikkawa M, Miura Y, Suzuki Y, Kitamura D. Oral bacteria induce IgA autoantibodies against a mesangial protein in IgA nephropathy model mice. Life Science Alliance. 2024. 7. 4. e202402588
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Yutaro Yada, Masanori Matsumoto, Takeshi Inoue, Akemi Baba, Ryota Higuchi, Chie Kawai, Masashi Yanagisawa, Daisuke Kitamura, Shouichi Ohga, Tomohiro Kurosaki, et al. STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells. Journal of Experimental Medicine. 2024. 221. 1
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Thomann AS, McQuade CA, Pinjušić K, Kolz A, Schmitz R, Kitamura D, Wekerle H, Peters A. A B cell-driven EAE mouse model reveals the impact of B cell-derived cytokines on CNS autoimmunity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023. 120. 47. e2300733120
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Shu Horiuchi, Takuya Koike, Hirofumi Takebuchi, Katsuaki Hoshino, Izumi Sasaki, Yuri Fukuda-Ohta, Tsuneyasu Kaisho, Daisuke Kitamura. SpiB regulates the expression of B-cell-related genes and increases the longevity of memory B cells. Frontiers in Immunology. 2023. 14
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MISC (18)：
Patents (27)：
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特定抗原特異的抗体を産生する細胞のスクリーニング方法
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IgA腎症に関連する自己抗体
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IgA腎症予防治療薬
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IgA腎症に関連する自己抗体
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B細胞集団の製造方法、及びそれを用いたモノクローナル抗体の製造方法
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Books (21)：
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岩波 生物学辞典 第5版
岩波書店 2013 ISBN:9784000803144
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分子細胞生物学事典
みみずく舎 2013 ISBN:9784863991699
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生物学辞典
東京化学同人 2010
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炎症・再生医学事典
朝倉書店 2009
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免疫応答と免疫病態の統合的分子理解
南山堂 2007 ISBN:9784525131111
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Lectures and oral presentations (148)：
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The contribution of IL-9 receptors on peritoneal B cells in T cell- independent immune responses
(第52回日本免疫学会学術集会 2024)
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Autoantibodies induced by commensal bacteria in the pathogenesis of IgA nephropathy
(第52回日本免疫学会学術集会 2024)
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共生細菌によるIgE自然抗体の産生制御機構
(第72回日本アレルギー学会学術大会 2023)
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IgA腎症における抗メサンギウムIgA型自己抗体の産生機構
(第20回日本免疫治療学会学術集会 2023)
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IgA腎症におけるメサンギウム細胞に対するIgA型自己抗体の同定とその産生機構
(第66回日本腎臓学会学術集会 2023)
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Education (2)：
- 1984 - 1988 Saga Medical School Graduate School, Division of Medicine
- 1978 - 1984 Saga Medical School Faculty of Medicine
Professional career (1)：
- M.D. (Saga Medical School)
Work history (5)：
- 1997 - 現在 東京理科大学大学院生命科学研究科 教授
- 1995 - 現在 Research Institute for Biomedical Sciences,Tokyo University of Science Professor
- 2006 - 2014 Department of Medicinal and Life Science,Faculty of Pharmaceutical Sciences, Tokyo University of Science Professor
- 1994 - 1995 Medical Institute of Bioregulation,Kyushu University Associate Professor
- 1988 - 1994 Medical Institute of Bioregulation,Kyushu University Research Assistant
Committee career (8)：
- 2018/05 - 現在 The Japanese Society for Immunology Associate Editor of International Immunology
- 1997/01 - 現在 日本免疫学会 評議員
- 2021/01/01 - 2024/12/31 日本免疫学会 評議員
- 2016/10/01 - 2020/12/31 日本免疫学会 評議員
- 2002/01 - 2005/12 Japanese Society for Immunology Editorial Board of Mirobiol. Immunol.
- 1997/01 - 2005/12 Transmitting Editor of Int. Immunol.
- 2001/01 - 2004/12 日本免疫学会 学術集会プログラム委員
- 2001/01 - 2004/12 日本免疫学会 JSIニュースレター編集委員
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Awards (2)：
- 2006 - The Asahi Research Award
- 1985 - The Asahi Research Award
Association Membership(s) (1)：
Japanese Society for Immunology
