Rchr
J-GLOBAL ID：200901025581345667
Update date: Nov. 06, 2024
Fukushige Shin'ichi
フクシゲ シンイチ | Fukushige Shin'ichi
Affiliation and department：
Job title：
Specially Appointed Professor
Homepage URL (1)：
http://www.diabetes.med.tohoku.ac.jp/
Research field (1)：
Experimental pathology
Research keywords (2)：
DNA mismatch repair
, Cancer Epigenetics
Research theme for competitive and other funds (18)：
- 2021 - 2024 Development of liquid biopsy technology targeting DNA methylation for prostate cancer diagnosis
- 2019 - 2022 Development of diagnostic technique of pancreatic cancer by using liquid biopsy targeted DNA methylation markers
- 2018 - 2022 Role of PYCARD, an apoptosis-inducing gene, in prostatic tumorigenesis
- 2015 - 2018 Identification of hypermethylated genes associated with increased cell proliferation of prostate cancer using DNA demethyation techniques
- 2012 - 2015 Development of DNA demethylation technology in cancer cells and its application for discovering biomarkers for early diagnosis
- 2009 - 2011 The search for DNA methylation-based biomarkers in cancer
- 2006 - 2007 Functional analysis of MBD proteins in epigenetic silencing of cancer-related genes
- 2005 - 2006 安定なRNA干渉を可能にするステーブル細胞株作製技術の開発
- 2005 - 2006 Mechanism of transcriptional silencing mediated by the methyl-CpG binding protein MBD4 and RET finger protein
- 2001 - 2002 Functional analysis of DNA mismatch protein hMLH1 using germline mutants
- 2000 - 2001 Reseearch on Genetic Alterations in the Development and Progression of Human Pancreatic Cancer
- 1999 - 2000 Identification of tumor suppressor genes by means of a genomic clone-transfer
- 1999 - 1999 Genetic alterations involved in initiation and progression of human cancer
- 1998 - 1999 Establishment of novel efficient methods for pancreatic cancer patients based on genetic abnormality.
- 1996 - 1999 DNA除去修復機構とその修復欠損の分子病態
- 1997 - 1998 環状酵母人工染色体(YAC)移入による癌抑制遺伝子の同定
- 1995 - 1996 Identification of tumor suppressor genes in human pancreatic cancer
- 1986 - 1988 Development of chromosome sorting techniques using a dual laser chromosome sorter
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Papers (96)：
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Toshiya Miyauchi, Shintaro Narita, Yuriko Saiki, Yukitsugu Kudo-Asabe, Akira Horii, Shinichi Fukushige, Tomonori Habuchi, Hiroshi Nanjo, Akiteru Goto. Association between NLRP3 Inflammasome and Tumor-Node-Metastasis Staging in Prostate Cancer: Immunohistochemical Studies of Prostate Needle Biopsy and Radical Prostatectomy Specimens. The Tohoku journal of experimental medicine. 2024
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Sho Fujiwara, Yuriko Saiki, Shinichi Fukushige, Mie Yamanaka, Masaharu Ishida, Fuyuhiko Motoi, Michiaki Unno, Akira Horii. TWIST1 is a prognostic factor for neoadjuvant chemotherapy for patients with resectable pancreatic cancer: a preliminary study. Surgery today. 2023
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Tomohiko Ishikawa, Shinichi Fukushige, Yuriko Saiki, Katsuya Hirose, Takako Hiyoshi, Takenori Ogawa, Yukio Katori, Toru Furukawa. Long Non-Coding RNAs Associated with Mitogen-Activated Protein Kinase in Human Pancreatic Cancer. Cancers. 2023. 15. 1. 303-303
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Shota Sora, Ariunbuyan Sukhbaatar, Shinichi Fukushige, Shiro Mori, Maya Sakamoto, Tetsuya Kodama. Combination therapy of lymphatic drug delivery and total-body irradiation in a metastatic lymph node and lung mouse model. Cancer science. 2022
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Masahiro Shiihara, Tomohiko Ishikawa, Yuriko Saiki, Yuko Omori, Katsuya Hirose, Shinichi Fukushige, Naoki Ikari, Ryota Higuchi, Masakazu Yamamoto, Takanori Morikawa, et al. Development of a system combining comprehensive genotyping and organoid cultures for identifying and testing genotype-oriented personalised medicine for pancreatobiliary cancers. European Journal of Cancer. 2021. 148. 239-250
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MISC (34)：
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日吉貴子, 斉木由利子, 佐々木彰之, 廣田嵩人, 平山明由, 曽我朋義, 福重真一, 堀井明. Cytidine deaminase plays a critical role in acquisition of gemcitabine resistance in a pancreatic cancer cell line. 日本癌学会学術総会抄録集(Web). 2019. 78th
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福重 真一, 宮内 隼弥, 大久保 鉄平, 齋木 由利子, 高橋 正博, 三塚 浩二, 荒井 陽一, 堀井 明. 前立腺腫瘍形成においてPYCARD遺伝子プロモーターのメチル化が高頻度に発生する. 日本癌学会総会記事. 2017. 76回. P-1153
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Shinichi Fukushige, Yasuhiko Mizuguchi, Kanchan Chakma, Yuriko Saiki, Akira Horii. Targeted TET oxidase activity through methyl-CpG binding domain extensively suppresses cancer cell proliferation. CANCER RESEARCH. 2016. 76. 2522-2533
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Shinichi Fukushige, Yasuhiko Mizuguchi, Akira Horii. TET oxidase activity accumulated on methyl-CpG sites extensively upregulates methylated genes through DNA demethylation. CANCER RESEARCH. 2014. 74. 19
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Na Chen, Yuriko Saiki, Hitoshi Sekine, Makoto Sunamura, Shinichi Fukushige, Fuyuhiko Motoi, Shinichi Egawa, Michiaki Unno, Akira Horii. IFI27 and NOV, downstream regulated genes by S100A4, are playing important roles in pancreatic carcinogenesis. CANCER RESEARCH. 2014. 74. 19
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Books (2)：
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Biomarkers in Cancer
Springer 2015 ISBN:9789400777446
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Cytochromes P450, Biochemistry, Biophysics and Drug Metabolism. 13th International Conference on Cytochromes P450.
Monduzzi Editore, Bologna (Italy) 2003
Lectures and oral presentations (60)：
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膵癌細胞株においてシチジンデアミナーゼの発現増加はゲムシタビン耐性獲得に関与する
(第78回日本癌学会学術総会 2019)
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IRX1の異常メチル化は前立腺癌に高頻度で発生し、増殖を活性化する
(第78回日本癌学会学術総会 2019)
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LHX6はエピジェネティックに不活性化される膵癌の癌抑制遺伝子候補である
(第78回日本癌学会学術総会 2019)
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PYCARDは前立腺癌において異常にメチル化し、発現低下している
(第78回日本癌学会学術総会 2019)
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アポトーシス誘導遺伝子PYCARDは前立腺癌でDNA高度メチル化により発現抑制される
(第108回日本病理学会総会 2019)
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Education (1)：
- - 1988 Osaka University Graduate School, Division of Medicine 生理系
Professional career (1)：
Committee career (4)：
- 2020/10 - 現在 International Journal of Molecular Sciences Editorial Board Member
- 2012/01 - 現在 Scientifica Academic Editor
- 2014/03 - 2018/12 Epigenetic Diagnosis & Therapy 編集委員
- 2010/06 - 2015/12 Genetics Research International 編集委員
Awards (2)：
- 2012/01/13 - 東北大学医学部 平成23年度東北大学医学部奨学賞金賞 癌におけるDNA高度メチル化を指標とするバイオマーカーの探索
- 2012/01/04 - 宮城県医師会 宮城県医師会医学奨励賞
Association Membership(s) (3)：
American Association for Cancer Research(2000/04-)
, 日本分子生物学会(1985/08-)
, 日本癌学会(1996/03-)
