Rchr
J-GLOBAL ID：200901026199528243
Update date: Dec. 09, 2024
Yamashita Fumiyoshi
ヤマシタ フミヨシ | Yamashita Fumiyoshi
Affiliation and department：
Job title：
Associate Professor
Research field (4)：
Clinical pharmacy
, Biomedical engineering
, Biomaterials
, Pharmaceuticals - analytical and physicochemistry
Research keywords (4)：
DDS
, 薬物動態学
, 薬剤学
, Pharmaceutics; Pharmacokinetics; Drug Delivery System
Research theme for competitive and other funds (33)：
- 2024 - 2027 Elucidation of Inflammatory Mechanisms by Nrf2 Regulation in a Smoking Exposure Model and Development of Novel Therapy for Laryngeal Inflammatory Disease
- 2023 - 2027 生体模倣デバイスを用いた腸運動異常を起点とする炎症スバイラルの解析
- 2023 - 2026 糖代謝疾患の時間発展評価を目指した仮想現実統合型生体チップモデルの開拓
- 2022 - 2026 低分子抗体を用いた幹細胞デリバリーによる肝線維化治療
- 2021 - 2024 Development of a microfluidic device that mimics inflammatory bowel disease caused by disruption of the intestinal flora
- 2018 - 2022 Targeted delivery of cell medicine by cell surface modification with low molecular weight antibody
- 2018 - 2022 Muti-step targeted drug delivery to endoplasmic reticulum via retrograde transport systems
- 2018 - 2021 Establishment of appropriate management of anti-HIV drugs to suppress the onset of HIV-associated neurocognitive disorder (HAND)
- 2016 - 2020 Development of safety evaluation system for DDS carrier based on network toxicology
- 2015 - 2018 Mechanism of anti-inflammatory action of self-assembling heparion nanoparticles
- 2010 - 2016 Establishment of Integrative Multi-level Systems Biology and its Applications
- 2013 - 2015 Development of novel gene-switch system inducing inflammatory tissue-selective gene expression and realizing DDS for stem cell
- 2013 - 2015 Full-automatic PopPK modeling utilizing an evolutionary algorithm
- 2011 - 2015 Integrated analysis of biological interaction of small molecules at the molecular level of living organisms
- 2011 - 2014 Therapeutic strategy of drug delivery systems utilizing unique tumor environment
- 2011 - 2012 Development of heparin-based nanoparticles with multi-functional biological properties intended for rheumatoid arthritis therapy
- 2009 - 2011 Natural Language Processing-Based Comprehensive Data Analysis for Interaction Between Chemicals and Drug Metabolism Network
- 2005 - 2009 Development of bioimaging method and targeted drug delivery system for inhibiting tumor proliferation and metastasis
- 2006 - 2008 Development of gene carriers based on in vivo and intracellular distribution real-time analysis
- 2006 - 2007 Natural language processing-based acquisition and analysis of information of drug metabolism
- 2003 - 2005 Strategy for optimization of in vivo gene delivery based on systemic control of delivery and transfection
- 2003 - 2004 Development of Novel Discrimination Model and Its Application to Predicting P-gp Substrate
- 2001 - 2002 Optimized the gene and drug delivery using liposomes based on the controlled liposomal surface property
- 2001 - 2002 Genetic Algorithm-Based Optimization of In Silico prediction Models for Oral Absorption
- 2000 - 2001 Development of local drug disposition analysis and delivery methods in human solid tumors
- 2000 - 2000 がん遺伝子治療の基盤となる遺伝子in vivoデリバリー法の開発
- 1999 - 2000 受容体介在性エンドサイトーシスを利用した活性酸素分解酵素のダブルターゲティング
- 1999 - 2000 遺伝子医薬品の体内動態および細胞取り込み機構の解明に基づくデリバリー戦略の確立
- 1999 - 2000 分子軌道法とニューラルネットワークを基盤とした薬物吸収予測システムの開発
- 1999 - 2000 角質バリアー機能におけるコルネオサイトエンベロープの生物物理学的意義の解明
- 1999 - 1999 がん遺伝子治療の基盤となる遺伝子in vivoデリバリー法の開発
- 1997 - 1998 皮膚内薬物代謝挙動を考慮した総合的経皮吸収動態モデルの確立
- 1994 - 1994 拡散モデルに基づく経皮吸収促進法の予測理論の確立:促進効果に及ぼす基剤の影響
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Papers (323)：
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Mizuki Uno, Yuta Nakamaru, Fumiyoshi Yamashita. Application of machine learning techniques in population pharmacokinetics/pharmacodynamics modeling. Drug metabolism and pharmacokinetics. 2024. 56. 101004-101004
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Chengyuan Zhu, Hiroyasu Takemoto, Yuriko Higuchi, Fumiyoshi Yamashita. Programmed immobilization of living cells using independent click pairs. Biochemical and Biophysical Research Communications. 2024. 699
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Mengyang Wang, Yuko Sasaki, Rena Sakagami, Tomotaka Minamikawa, Masahiro Tsuda, Ryohei Ueno, Sayaka Deguchi, Ryosuke Negoro, Kanako So, Yuriko Higuchi, et al. Perfluoropolyether-Based Gut-Liver-on-a-Chip for the Evaluation of First-Pass Metabolism and Oral Bioavailability of Drugs. ACS Biomaterials Science and Engineering. 2024
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山下 富義, 王 夢洋, 津田 真弘, 樋口 ゆり子, 高山 和雄. 経口バイオアベイラビリティー評価のための腸肝連結マイクロ流体チップの開発. 日本薬剤学会年会講演要旨集. 2023. 38年会. 252-252
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Ryohei Ueno, Masahiro Kuninori, Takumi Sumi, Ramin Banan Sadeghian, Yuji Takata, Azusa Iguchi, Masahiro Tsuda, Fumiyoshi Yamashita, Kentaro Ichikawa, Ryuji Yokokawa. Relationship between Adsorption and Toxicity of Nephrotoxic Drugs in Microphysiological Systems (MPS). Micromachines. 2023. 14. 4. 761-761
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MISC (94)：
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高谷直樹, 津田真弘, 宗可奈子, 樋口ゆり子, 山下富義. Increased gene and functional expression of P-glycoprotein in Caco-2 by streching stress stimulation. 日本薬剤学会年会講演要旨集(CD-ROM). 2022. 37th
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出口清香, 出口清香, 津田真弘, 小杉香織, 前田和哉, 楠原洋之, 水口裕之, 水口裕之, 山下富義, 鳥澤勇介, et al. Generation and application of polydimethylsiloxane-based liver-on-a-chip for pharmacokinetic studies. 日本薬学会年会要旨集(Web). 2021. 141st
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Kurebayashi Nagomi, Murayama Takashi, Ohta Ryosaku, Yamashita Fumiyoshi, Suzuki Junji, Kanemaru Kazunori, Iino Masamitsu, Sakurai Takashi. Regulation of Store Ca2+ Level in HEK293 Cells Expressing Type 2 Ryanodine Receptor (RyR2) with CPVT Mutations. BIOPHYSICAL JOURNAL. 2018. 114. 3. 117A
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Fumiyoshi Yamashita. Dynamic simulation of drug-drug interactions by using multi-level physiological modeling & simulation platforms. Yakugaku Zasshi. 2018. 138. 3. 347-351
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Kurebayashi Nagomi, Murayama Takashi, Tetsuo Naoyuki, Ohta Ryosaku, Yamashita Fumiyoshi, Suzuki Junji, Kanemaru Kazunori, Iino Masamitsu, Kurikawa Junk, Sakurai Takashi. Modulation of Ca2+ dynamics by disease-linked RyR2s in cultured non-cardiac and cardiac cells. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2017. 133. 3. S133
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Patents (4)：
Books (15)：
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Dr. 北野の0から始めるシステムバイオロジー
羊土社 2015
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薬剤学実験法必携マニュアル
2014
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第7版化学便覧 応用化学編
丸善 2014
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薬物の消化管吸収予測研究の最前線
メディカルドゥ 2010
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インシリコ創薬科学
京都廣川書店 2008
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Lectures and oral presentations (14)：
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Targeted delivery of drugs, genes, and cells by using specialized ligand-receptor recognition systems
(International Conference and Exhibition on Pharmaceutical Sciences and Technology 2020 2020)
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Informatic Technologies for the Prediction of Pharmacokinetic Behaviors
(2018 International Conference of The Korean Society of Pharmaceutical Sciences and Technology 2018)
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Application of machine learning techniques to pharmacokinetic analysis
(13th France-Japan Drug Delivery System Symposium 2018)
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Curriculum towards training pharmacist scientists: Case in Kyoto University
(The 7th Conference of Asia Pacific Pharmacy Education Network 2018)
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創薬テクノロジーとしてのDDS
(立命館大学創薬科学研究センター 創剤研究コンソーシアム・製剤技術研究コンソーシアム 2018年合同研究会 2018)
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Education (2)：
- - 1991 Kyoto University
- - 1988 Kyoto University Faculty of Pharmaceutical Sciences
Professional career (1)：
- Doctor of Pharmaceutical Science (Kyoto University)
Work history (5)：
- 2016/08 - 現在 Kyoto University Graduate School of Pharmaceutical Sciences Professor
- 2007/04 - 2016/07 Kyoto University Graduate School of Pharmaceutical Sciences Associate Professor
- 1997/09 - 2007/03 Kyoto University Graduate School of Pharmaceutical Sciences Associate Professor
- 1997/04 - 1997/08 Kyoto University Graduate School of Pharmaceutical Sciences Junior Assistant Professor
- 1991/12 - 1997/03 Kyoto University Faculty of Pharmaceutical Sciences Junior Assistant Professor
Awards (3)：
- 2023/06 - The Japanese Society of Toxicology Tanabe Award
- 2001 - 平成13年度日本薬剤学会旭化成製剤学奨励賞
- 2001 - Asahi Kasei Pharmaceutics Young Investigator Award
Association Membership(s) (4)：
日本DDS学会
, 日本薬剤学会
, 日本薬物動態学会
, 日本薬学会
