Hishinuma Shigeru

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.my-pharm.ac.jp/

Research keywords (1)：受容体と細胞内情報伝達の制御機構

Research theme for competitive and other funds (12)：

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Papers (56)：

Yutaka Koyama, Yasuhiro Hamada, Yura Fukui, Nami Hosogi, Rina Fujimoto, Shigeru Hishinuma, Yasuhiro Ogawa, Kenta Takahashi, Yasuhiko Izumi, Shotaro Michinaga. Endothelin-1 increases Na+-K+-2Cl- cotransporter-1 expression in cultured astrocytes and in traumatic brain injury model: An involvement of HIF1α activation. Glia. 2024
Shotaro Michinaga, Ayaka Nagata, Ryosuke Ogami, Yasuhiro Ogawa, Shigeru Hishinuma. Histamine H₁ Receptor-Mediated JNK Phosphorylation Is Regulated by G_q Protein-Dependent but Arrestin-Independent Pathways. International Journal of Molecular Sciences. 2024
Shotaro Michinaga, Ayaka Nagata, Ryosuke Ogami, Yasuhiro Ogawa, Shigeru Hishinuma. Differential regulation of histamine H1 receptor-mediated ERK phosphorylation by Gq proteins and arrestins. Biochemical Pharmacology. 2023. 213. 115595-115595
Shotaro Michinaga, Shigeru Hishinuma, Yutaka Koyama. Roles of Astrocytic Endothelin ETB Receptor in Traumatic Brain Injury. Cells. 2023. 12. 5. 719-719
Shotaro Michinaga, Kiyomi Sonoda, Naoki Inazuki, Manae Ezaki, Hiroki Awane, Kahori Shimizu, Shigeru Hishinuma, Hiroyuki Mizuguchi. Selective histamine H2 receptor agonists alleviate blood-brain barrier disruption by promoting the expression of vascular protective factors following traumatic brain injury in mice. Journal of Pharmacological Sciences. 2022. 150. 3. 135-145

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MISC (24)：

中井喬之, 津田鷹秀, 三田充男, 菱沼滋, 野澤玲子, 庄司優. 小細胞肺癌細胞における電位依存性Naチャネル発現に対するNa負荷とフェニトインの影響. 日本内分泌学会雑誌. 2015. 91. 2
Shigeru Hishinuma, Kenta Sugawara, Yoshihiro Uesawa, Hiroyuki Fukui, Masaru Shoji. Differential thermodynamic driving force of first- and second-generation antihistamines to determine their binding affinity for human H-1 receptors (vol 91, pg 231, 2014). BIOCHEMICAL PHARMACOLOGY. 2014. 92. 2. 403-403
櫛部洋, 志村明日香, 津田鷹秀, 中井喬之, 小林祐貴, 矢沢勇士, 三田充男, 菱沼滋, 野澤玲子, 庄司優. 小細胞肺癌細胞のバゾプレシン産生に対するフェニトインの抑制効果. 日本内分泌学会雑誌. 2014. 90. 2
Hiroki Nozawa, Chizuru Akatsu, Shigeru Hishinuma, Masaru Shoji. Agonist-induced internalization of human histamine H-1 receptor is regulated by its C-terminal. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 164P-164P
Kiyoe Kosaka, Chizuru Akatsu, Hiroyuki Fukui, Shigeru Hishinuma, Masaru Shoji. Allosteric modulation by Na+ of the affinity of ligands for human histamine H-1 receptors in Chinese hamster ovary cells. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 164P-164P

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Books (1)：

Works (1)：

Committee career (4)：

Association Membership(s) (3)：

日本薬学会 , 日本生化学会 , 日本薬理学会

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