Mizutani Kimihiko

ミズタニキミヒコ | Mizutani Kimihiko

Affiliation and department：
Job title： Assistant Prof.
Other affiliations (3)：

Ryukoku University Faculty of Agriculture Department of Food Nutrition
Kyoto Sangyo University Faculty of Life Sciences
Doshisha Women's College of Liberal Arts Faculty of Human Life and Science Department of Food Studies of Nutrition

Homepage URL (1)： http://www.structure.kais.kyoto-u.ac.jp/lab/mizutani.html

Research field (8)： Biophysics , Applied microbiology , Applied biochemistry , Structural biochemistry , Horticulture , Environmental agriculture , Biological resource conservation , Basic physical chemistry

Research keywords (6)：タンパク質分子の構造と機能の解析 , 遺伝子組換え酵母を用いたタンパク質の生産 , 有用植物の増殖法の開発と応用 , 環境中タンパク質のプロテオーム解析 , 外来生物の駆除と利用 , バイオインフォマティックス用プログラム、フォントの開発

Research theme for competitive and other funds (12)：

2024 - 2027 脳内pH低下に伴うNELL-ROBOシグナルの変容と神経細胞機能の統合的理解
2020 - 2024 新規シグナル伝達系・NELL-Roboシグナルの骨形成における作用機序の解明
2016 - 2019 Comprehensive understanding on the metabolism of prenylated polyphenols in plants
2013 - 2017 Cell surface expression of proteins using Pichia yeast: Development and application of high-throuput construction of expression system
2010 - 2012 超高分解能でのX線結晶構造解析によるトランスフェリンの共同性アニオン結合機構の解明:ドラッグデリバリーの基盤研究

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Papers (37)：

Yuki Odagaki, Yui Murakami, Teisuke Takita, Kimihiko Mizutani, Bunzo Mikami, Shinsuke Fujiwara, Kiyoshi Yasukawa. Unveiling the reaction mechanism of arginine decarboxylase in Aspergillus oryzae: Insights from crystal structure analysis. Biochemical and biophysical research communications. 2024. 733. 150728-150728
Tomoka Nakamura, Teisuke Takita, Kohei Kuwata, Kimihiko Mizutani, Bunzo Mikami, Satoshi Nakamura, Kiyoshi Yasukawa. Activity-stability trade-off observed in variants at position 315 of the GH10 xylanase XynR. Scientific reports. 2024. 14. 1. 7767-7767
Tomoka Nakamura, Kohei Kuwata, Teisuke Takita, Kimihiko Mizutani, Bunzo Mikami, Satoshi Nakamura, Kiyoshi Yasukawa. Effects of amino acid substitutions at position 315 of GH10 xylanase XynR on its alkaliphily. Journal of Biological Macromolecules. 2024. 24. 1. 11-16
Saori Ueshima, Mizuki Yasumoto, Yuto Kitagawa, Kaho Akazawa, Teisuke Takita, Keisuke Tanaka, Shunji Hattori, Kimihiko Mizutani, Bunzo Mikami, Kiyoshi Yasukawa. Insights into the catalytic mechanism of Grimontia hollisae collagenase through structural and mutational analyses. FEBS letters. 2023. 597. 19. 2473-2483
Ryota Hashizume, Yukiko Maki, Kimihiko Mizutani, Nobuyuki Takahashi, Hiroyuki Matsubara, Akiko Sugita, Kimihiko Sato, Shotaro Yamaguchi, Bunzo Mikami. Correction: Crystal structures of protein glutaminase and its pro forms converted into enzyme-substrate complex. The Journal of biological chemistry. 2023. 299. 8. 105137-105137

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MISC (10)：

Mikami Bunzo, Adachi Motoyasu, Mizutani Kimihiko, Takahashi Nobuyuki, Kang You-Na, Hirata Akira, Yamane Aiko, Saka Naoki, Kawamura Hirokazu, Hou Xueni, et al. [Review] Crystal Structure Analysis of β-Amylase/Saccharide Complexes Measured at Different pH and Room Temperature. Bulletin of Applied Glycoscience. 2021. 11. 2. 79-86
水谷公彦, 水谷由記子. 塩濃度の最適化を利用したポリエチレングリコールベースの新しい結晶化スクリーニングキット. 蛋白質科学会アーカイブ. 2019. 12. e095
Kimihiko Mizutani. High-throughput plasmid construction using homologous recombination in yeast: its mechanisms and application to protein production for X-ray crystallography. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY. 2015. 79. 1. 1-10
Kimihiko Mizutani, Mayuko Toyoda, Bunzo Mikami. X-ray structures of transferrins and related proteins. Biochimica et Biophysica Acta - General Subjects. 2012. 1820. 3. 203-211
三上文三, 水谷公彦, 田邊愛子, 高橋延行, 廣瀬正明. Function clarification of ovotransferrin by ultra high resolution X-ray crystal structure analysis. 杉山産業化学研究所年報. 2008. 2008. 25-36

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Lectures and oral presentations (82)：

X-ray crystallographic analysis of a major cargo protein of extracellular membrane vesicles of a hypervesiculating bacterium, Shewallena vesiculosa HM13
(2024)
Metabolism of nonsteroidal anti-inflammatory drugs (NSAIDs) by the R84A mutant of actinomycete-derived P450 (CYP105A1)
(2024)
Crystal structure of Grimontia hollisae collagenase
(2023)
Streptomyces moboraensis由来トランスグルタミナーゼの高純度成熟体の精製法の検討
(生物高分子 2023)
放線菌由来P450(CYP105A1)の機能改変と医薬品代謝研究への応用:R84A変異体による非ステロイド性抗炎症薬(NSAIDs)の代謝
(生物高分子 2023)

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Works (3)：

Ricty Diminishedのリガチャ対応漢字拡張版(Ligty ShinDiminished)
水谷公彦 2023 - 現在
Ricty Diminishedの漢字拡張版(Ricty ShinDiminished)
水谷公彦 2023 - 現在
プログラミング、バイオインフォマティックス用フォントIncoUDJP(インコ・ユニバーサルデザイン日本語プログラミングフォント)
水谷公彦 2022 - 現在

Education (3)：

1997 - 1999 Kyoto University Graduate School of Agriculture Division of Applied Life Sciences
1995 - 1997 Kyoto University Graduate School of Agriculture
1991 - 1995 Nagoya University Faculty of Agriculture

Professional career (2)：

Doctor of Agriculture (Kyoto University)
Master of Agriculture (Kyoto University)

Work history (8)：

2020/09 - 現在 Kyoto Sangyo University Faculty of Life Sciences
2020/04 - 現在 Ryukoku University Faculty of Agriculture Department of Food Nutrition
2007/04 - 現在 Kyoto University Graduate School of Agriculture Assistant prof
- 現在 Doshisha Women's College of Liberal Arts Faculty of Human Life and Science Department of Food Studies of Nutrition
2010/04 - 2013/09 Kindai University Faculty of Agriculture Department of Fisheries

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Committee career (8)：

2018/12 - 2022/12 滋賀県琵琶湖レジャー利用適正化審議会委員
2022/03 - 日本農芸化学会ジュニア農芸化学会2022審査員
2009/05 - 2017/06 日本蛋白質科学会蛋白質科学会アーカイブ編集委員
2012/05 - 日本生化学会 2012年度近畿支部例会実行委員
2012 - 日本農芸化学会大会プログラム編成委員

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Awards (5)：

2016/03 - 滋賀県しが生物多様性大賞特別賞
2013/03 - Japan Society for Bioscience, Biotechnology, and Agrochemistry JSBBA Award for Young Scientists
2011/03 - 日本農芸化学会日本農芸化学会 2011 年度大会トピックス賞結晶構造に基づくプロテイングルタミナーゼの酵素機能解析
2010/03 - 日本農芸化学会日本農芸化学会 2010 年度大会トピックス賞ヒト苦味受容体(hTAS2R16)の酵母を用いた発現系構
2008/05 - 環境省野生生物保護功労者表彰環境省自然環境局長賞

Association Membership(s) (2)：

Protein Science Society of Japan , JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY

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