Rchr
J-GLOBAL ID：200901026643356543
Update date: Nov. 21, 2024
Taguchi Keiko
タグチ ケイコ | Taguchi Keiko
Affiliation and department：
Job title：
Associate Professor
Research field (3)：
Food sciences
, Medical biochemistry
, Pharmaceuticals - health and biochemistry
Research keywords (3)：
食品化学
, 衛生薬学
, Biochemistry
Research theme for competitive and other funds (15)：
- 2022 - 2025 肝臓の組織構築におけるNrf2の新たな機能
- 2022 - 2025 硫黄生物学から紐解く膵癌難治化機構の解明と治療応用
- 2019 - 2024 Deciphering Molecular Basis for the Anti-Oxidative Stress Response and Application of the Basis for Disease Prevention and Therapy
- 2019 - 2022 Development of esophagus cancer acquired Nrf2 activation
- 2019 - 2022 Development of novel therapy for pancreatic cancer based on the regulation of oxidative stress responses
- 2019 - 2020 生体の酸化ストレス応答の分子メカニズム解明とその疾病予防・治療への応用
- 2016 - 2018 オートファジー破綻がもたらす病態のNrf2を標的とした治療戦略
- 2015 - 2018 Role of oxidative stress response in pancreatic diseases and therapeutic application
- 2016 - 2018 Hepatic tumor and Nrf2 activation by impaired autophagy(Fostering Joint International Research)
- 2014 - 2017 Hepatic tumor and Nrf2 activation by impaired autophagy
- 2013 - 2015 肝疾患における転写因子Nrf2の機能変化
- 2012 - 2014 Role of Nrf2 in compensatory liver proliferation after portal vein branch ligation in mice
- 2011 - 2013 Keap1-Nrf2システムとAktシグナルの相互作用と肝疾患
- 2010 - 2011 Pathogenesis by disrupting the cytoprotective system
- 2007 - 2011 Molecular Mechanisms of Adaptive Responses to Food and Oxygen
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Papers (94)：
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Atsushi Inose-Maruyama, Hayato Irokawa, Kouki Takeda, Keiko Taguchi, Masanobu Morita, Masayuki Yamamoto, Masato Sasaki, Shusuke Kuge. Bag1 protein loss sensitizes mouse embryonic fibroblasts to glutathione depletion. Cell stress & chaperones. 2024. 29. 3. 497-509
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Yu-Ichi Aoki, Keiko Taguchi, Hayato Anzawa, Junko Kawashima, Noriko Ishida, Akihito Otuki, Atsushi Hasegawa, Liam Baird, Takafumi Suzuki, Ikuko N Motoike, et al. Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals. Journal of biochemistry. 2024. 175. 6. 611-627
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Xinying Ye, Takashi Toyama, Keiko Taguchi, Kotoko Arisawa, Takayuki Kaneko, Ryouhei Tsutsumi, Masayuki Yamamoto, Yoshiro Saito. Sulforaphane decreases serum selenoprotein P levels through enhancement of lysosomal degradation independent of Nrf2. Communications Biology. 2023. 6. 1. 1060-1060
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Liam Baird, Keiko Taguchi, Anqi Zhang, Yushi Takahashi, Takafumi Suzuki, Thomas W. Kensler, Masayuki Yamamoto. A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells. Redox Biology. 2023. 66. 102845-102845
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Marta Anna Kowalik, Keiko Taguchi, Marina Serra, Andrea Caddeo, Elisabetta Puliga, Marina Bacci, Seizo Koshiba, Jin Inoue, Eiji Hishinuma, Andrea Morandi, et al. Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes. Hepatology (Baltimore, Md.). 2023. 79. 4. 829-843
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MISC (128)：
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伊藤ゆり, 井澤武史, 濱田菜々子, 田中美有, 田口恵子, 田口恵子, 山本雅之, 桑村充. Study on the activation of Nrf2 system in thioacetamide-induced GSTp-positive hepatocyte foci. 日本毒性病理学会総会及び学術集会講演要旨集. 2024. 40th
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押切裕之, 押切裕之, 田口恵子, 谷山裕亮, 山本雅之, 亀井尚. 食道扁平上皮癌細胞におけるNRF2とNQO1の発現とゲルダナマイシン誘導体の増殖抑制. 日本食道学会学術集会抄録集(CD-ROM). 2024. 78th
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田口恵子. NRF2-addicted Cancer: From Classical Experimental Animal Models toward Diagnosis and Treatment. Journal of Toxicological Sciences. 2023. 48. Supplement (CD-ROM)
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田口恵子, 田口恵子, 田口恵子. Nrf2 and iron metabolism in liver tumorigenesis. 肝胆膵. 2022. 84. 4
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廣瀬亘, 堀内真, 田口恵子, 谷山裕亮, 山本雅之, 亀井尚. 細胞競合によるNRF2活性化細胞の排除機構. 日本食道学会学術集会抄録集(CD-ROM). 2022. 76th
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Books (6)：
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酸化ストレスの医学改訂第2版
診断と治療社 2014
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毒性の科学:分子・細胞から人間集団まで
東京大学出版会 2014
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Protein modifications in pathogenic dysregulation of signaling
Springer 2014
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実験医学増刊号
羊土社 2012
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実験医学増刊号
羊土社 2012
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Lectures and oral presentations (105)：
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Pathophysiological Analyses in the Liver of KEAP1 knockout rats
(2024)
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Pathophysiological Analyses in the Liver of KEAP1 knockout rats
(2024)
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KEAP1-NRF2システムにおける付加体形成
(第51回日本毒性学会学術年会 2024)
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NRF2活性化がん:古き実験動物モデルから診断と治療に向けて
(第50回日本毒性学会学術年会 2024)
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Metabolic Reprogramming in Nrf2-driven Proliferation of Normal Rat Hepatocytes by Lead Nitrate
(The Environmental Response VI 2023)
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Professional career (1)：
- Ph.D. in Medicine (University of Tsukuba)
Work history (5)：
- 2023/06 - 現在 Tohoku Medical Megabank Organization, Tohoku University Visiting Associate Professor
- 2023/06 - 現在 Graduate School of Agricultural and Life Sciences, The University of Tokyo Laboratory of Food Chemistry, Department of Applied Biological Chemistry Associate Professor
- 2017/04 - 2020/03 Tohoku University Graduate School of Medicine Senior Assistant Professor
- 2008/01 - 2017/03 Tohoku University Graduate School of Medicine Assistant Professor
- 2006/04 - 2007/12 科学技術振興機構 JST-ERATO山本環境応答プロジェクト 技術員・研究員
Committee career (7)：
Awards (9)：
- 2020/01 - 東北大学医学部 東北大学医学部奨学賞(金賞) Keap1-Nrf2システムによる生体機能制御機構の解明
- 2017/07 - The Japanese Scociety of Toxicology The JSOT Young Scientist Award
- 2016/07 - The Naito Foundation 41st Naito Conference Poster Award Nrf2 is a critical factor for hepatocellular adenoma in impaired autophagy
- 2015/12 - Japanese Biochemical Society Young Investigator Award
- 2013/09 - 倶進会・日本生化学会 第10回柿内三郎記念奨励研究賞
- 2012/06 - 内藤記念科学振興財団 33rd Naito Conference Poster Award Crosstalk between Keap1-Nrf2 system and Pten-PI3K-Akt signaling regulates cellular proliferation and differentiation
- 2012/04 - UK-Japan Research Symposium: Molecular Mechanisms of Stress Response in Disease The Best Poster Award Keap1 Degradation by Autophagy for the Maintenance of Redox Homeostasis
- 2011/01/14 - 東北大学 平成22年度東北大学医学部奨学賞(銀賞) Nrf2-Keap1生体防御システムの機能とその破綻による病態の解明
- 2008/10/18 - 日本薬学会 日本薬学会環境・衛生部会賞 酸化ストレスを生じるディーゼル排出微粒子成分の毒性発現と生体防御機構の解明
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Association Membership(s) (6)：
Japan Scoety for Bioscience, Biotechnology, and Agrochemistry
, Sociey of Toxicology
, 日本生化学会(2009/09-)
, 日本癌学会(2009/02-)
, 日本毒性学会(2007/01-)
, 日本薬学会(2004/02-)
