Rchr
J-GLOBAL ID：200901026694164428
Update date: Apr. 25, 2024
Sakai Wataru
サカイ ワタル | Sakai Wataru
Affiliation and department：
Job title：
Assistant Professor
Research field (3)：
Cell biology
, Molecular biology
, Genetics
Research keywords (4)：
ファンコニ貧血
, DNA損傷応答・修復
, 抗がん剤耐性
, アルデヒド
Research theme for competitive and other funds (5)：
- 2020 - 2023 ファンコニ貧血における脂肪族アルデヒド代謝の影響
- 2017 - 2020 ファンコニ貧血タンパク質とアルデヒド代謝の新たな相互制御関係の解明
- 2011 - 2016 Cross-regulation of the maintenance and mutagenesis of genomic sequence and epigenetic information
- 2014 - 2016 ファンコニ貧血症タンパク質によるアポトーシス制御に関わる新たな分子機構の解明
- 2010 - 2012 Analysis of a novel molecular mechanism for decision of cell fate in response to DNA damage
Papers (24)：
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Hirotaka Kobayashi, Franklin Mayca Pozo, Wataru Sakai, Kenji Sato, Kaoru Sugasawa. Identification of novel mutations and reassignment of archival xeroderma pigmentosum group C cell strains from Japanese patients. The Journal of dermatology. 2022. 50. 3. 407-408
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Masayuki Kusakabe, Erina Kakumu, Fumika Kurihara, Kazuki Tsuchida, Takumi Maeda, Haruto Tada, Kanako Kusao, Akari Kato, Takeshi Yasuda, Tomonari Matsuda, et al. Histone deacetylation regulates nucleotide excision repair through an interaction with the XPC protein. iScience. 2022. 25. 4. 104040-104040
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Wataru Sakai, Mayumi Yuasa-Sunagawa, Masayuki Kusakabe, Aiko Kishimoto, Takeshi Matsui, Yuki Kaneko, Jun-Ichi Akagi, Nicolas Huyghe, Masae Ikura, Tsuyoshi Ikura, et al. Functional impacts of the ubiquitin-proteasome system on DNA damage recognition in global genome nucleotide excision repair. Scientific reports. 2020. 10. 1. 19704-19704
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Masayuki Kusakabe, Yuki Onishi, Haruto Tada, Fumika Kurihara, Kanako Kusao, Mari Furukawa, Shigenori Iwai, Masayuki Yokoi, Wataru Sakai, Kaoru Sugasawa. Mechanism and regulation of DNA damage recognition in nucleotide excision repair. Genes and environment : the official journal of the Japanese Environmental Mutagen Society. 2019. 41. 2-2
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Wataru Sakai, Kaoru Sugasawa. Importance of finding the bona fide target of the Fanconi anemia pathway. Genes and environment : the official journal of the Japanese Environmental Mutagen Society. 2019. 41. 6-6
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MISC (11)：
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Wataru Sakai, Kaoru Sugasawa. DNA damage recognition and repair in mammalian global genome nucleotide excision repair. DNA Replication, Recombination, and Repair: Molecular Mechanisms and Pathology. 2016. 155-174
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Wataru Sakai, Aiko Kishimoto, Takeshi Matsui, Jun-ichi Akagi, Kaoru Sugasawa. Studies on the de-ubiquitination mechanism for the xeroderma pigmentosum group C protein in UV damage response. GENES & GENETIC SYSTEMS. 2015. 90. 6. 397-397
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Syota Matsumoto, Masaki Akita, Wataru Sakai, Kaoru Sugasawa. Post-translational modifications coordinating recognition and repair of UV-induced DNA damage. DNA REPAIR. 2015. 28. 144-144
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Aiko Kishimoto, Junichi Akagi, Takeshi Matsui, Wataru Sakai, Kaoru Sugasawa. Studies on the de-ubiquitylation mechanism of the xeroderma pigmentosum group C protein. GENES & GENETIC SYSTEMS. 2014. 89. 6. 312-312
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岸本藍子, 赤木純一, 松井豪志, 酒井恒, 菅澤薫. 紫外線損傷修復におけるXPCタンパク質の脱ユビキチン化機構の解析. 日本遺伝学会大会プログラム・予稿集. 2014. 86th. 99
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Books (1)：
Lectures and oral presentations (92)：
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損傷クロマチン基質を用いたヌクレオチド除去修復制御機構の生化学的解析
(第41回染色体ワークショップ・第22回核ダイナミクス研究会 2024)
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ヌクレオチド除去修復の損傷監視制御におけるヒストン修飾の役割
(第41回染色体ワークショップ・第22回核ダイナミクス研究会 2024)
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ヌクレオチド除去修復のDNA損傷認識制御におけるヒストンH3K9メチル化修飾の役割
(第46回日本分子生物学会年会 2023)
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紫外線誘発DNA損傷に対する細胞応答におけるクロマチンリモデリング因子SMARCAD1の関与
(第46回日本分子生物学会年会 2023)
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DNAポリメラーゼ‧イータの発現調節における脱ユビキチン化酵素USP11の関与
(第46回日本分子生物学会年会 2023)
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Education (1)：
- - 2004 Saitama University Graduate School of Science and Engineering
Awards (2)：
- 2017/11 - Japanese Environmental Mutagen Society Oxford Journal Award
- 2017/09 - Fanconi Anemia Research Fund Travel Award Fatty aldehyde dehydrogenase as a novel binding partner of FANCD2
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