Research theme for competitive and other funds (18):
2022 - 2025 Osteoclast fusion mechanism based on plasma membrane curvature and tension
2019 - 2022 A feedback mechanism between the plasma membrane and the actin cytoskeleton underneath during cell migration
2016 - 2019 Role of plasma membrane tension in cell polarity
2014 - 2019 Molecular mechanisms of cell competition between normal and transformed cells
2015 - 2018 Structural analysis of membrane-deforming SYLF domain proteins
2011 - 2016 Regulation of cell dynamism by phosphoinositides
2012 - 2015 Ferチロシンキナーゼの天然変性領域を介した細胞膜結合による活性化機構
2012 - 2015 Molecular mechanism of endocytosis by a novel membrane-bending domain
2009 - 2010 Regulation of phospholipid metabolisms by IRBIT family
2009 - 2010 Analysis on regulatory mechanisms for endocytosis mediated by membrane-bending proteins
2006 - 2010 Spatial and temporal regulation of signalling molecules by phosphoinositides
2007 - 2008 曲面としての細胞膜における膜の曲率依存的なシグナル伝達機構
2006 - 2007 エンドサイトーシスにおけるF-BARドメインの役割
2006 - 2007 F-BARドメインタンパクによる細胞膜の形状制御機構
2002 - 2002 細胞膜受容体のエンドサイトーシスによる細胞増殖制御機構の解明
2001 - 2002 イノシトールリン脂質を介したエンドサイトーシス制御機構の解明
2000 - 2002 Dynamic reorganization of cytoskeletion by WASP family proteins
1998 - 1998 ホスファチジルイノシトール4リン酸5キナーゼの活性制御機構の解析
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Papers (55):
Toshiki Itoh, Kazuya Tsujita. Exploring membrane mechanics: The role of membrane-cortex attachment in cell dynamics. Current Opinion in Cell Biology. 2023. 81. 102173-102173
Kaori Kanemaru, Makoto Shimozawa, Manabu Kitamata, Rikuto Furuishi, Hinako Kayano, Yui Sukawa, Yuuki Chiba, Takatsugu Fukuyama, Junya Hasegawa, Hiroki Nakanishi, et al. Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics. Nature Communications. 2022. 13. 1
Shinya Yuge, Koichi Nishiyama, Yuichiro Arima, Yasuyuki Hanada, Eri Oguri-Nakamura, Sanshiro Hanada, Tomohiro Ishii, Yuki Wakayama, Urara Hasegawa, Kazuya Tsujita, et al. Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins. Nature Communications. 2022. 13. 1
Kazuya Tsujita, Reiko Satow, Shinobu Asada, Yoshikazu Nakamura, Luis Arnes, Keisuke Sako, Yasuyuki Fujita, Kiyoko Fukami, Toshiki Itoh. Homeostatic membrane tension constrains cancer cell dissemination by counteracting BAR protein assembly. Nature Communications. 2021. 12. 1
Tomoko Kamasaki, Yumi Miyazaki, Susumu Ishikawa, Kazuya Hoshiba, Keisuke Kuromiya, Nobuyuki Tanimura, Yusuke Mori, Motosuke Tsutsumi, Tomomi Nemoto, Ryota Uehara, et al. FBP17-mediated finger-like membrane protrusions in cell competition between normal and RasV12-transformed cells. iScience. 2021. 24. 9. 102994-102994
S. Kurisu, T. Itoh, T. Takenawa. Microvillar tip-localized interaction between IRSp53 and PI(4,5)P2 drives brush border assembly in kidney epithelial cells. MOLECULAR BIOLOGY OF THE CELL. 2014. 25
THE JAPANESE CANCER ASSOCIATION
, THE JAPANESE CONFERENCE ON THE BIOCHEMISTRY OF LIPIDS
, JAPAN SOCIETY FOR CELL BIOLOGY
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE JAPANESE BIOCHEMICAL SOCIETY