Rchr
J-GLOBAL ID:200901026845243856
Update date: Nov. 06, 2024
YAMASHITA Jun K.
ヤマシタ ジュン | YAMASHITA Jun K.
Affiliation and department:
Job title:
Project Professor
Homepage URL (1):
https://www.u-tokyo.ac.jp/focus/ja/people/k0001_04592.html
Research field (3):
Cardiology
, Medical biochemistry
, Anatomy
Research keywords (10):
extracellular vesicles
, 血管
, 心臓
, 多能性幹細胞
, 再生
, 分化
, Cardiovascular development
, ES(Embryonic Stem)cells
, Regeneration
, Differentiation
Research theme for competitive and other funds (54):
- 2020 - 2023 細胞機能検出プローブを用いた3次元組織の動態・機能イメージング技術の開発
- 2020 - 2023 Trials to reconsitute stem cell system in the heart for cardiac regeneration
- 2019 - 2022 Identification of molecular mechanisms of RNF213-related occlusive cerebrovascular diseases and development of new treatment strategies
- 2017 - 2022 分化再生と生体恒常性を制御するエクソソームの新しい細胞同調機能の解明とナノ粒子による生体機能制御への応用
- 2018 - 2021 Exploration of novel in vitro lethal arrhythmia models with 3D tissues from human iPS cells
- 2017 - 2019 Next generation in vitro tissue/organ models with 3D tissue from stem cells
- 2015 - 2018 In vitro evaluation system for cardiac contraction using human iPS cell-derived 3-D cardiac tissue
- 2015 - 2018 Novel cardiomyocyte-fated progenitors from human iPS cells for cardiac regeneration
- 2015 - 2018 Investigation for the attenuation of arrhythmia related to human iPS cell-based cardiac regenerative therapy
- 2015 - 2018 Development of human iPS cell-derived multidisciplinary thick viable organized tissues aiming for myocardial regenerative therapy
- 2015 - 2018 Development of a new vascular regenerative therapy for severe limb ischemia by the transplantation of human iPS cell-derived vascular cells
- 2014 - 2018 Anti-vascular diseases approach through the analysis of vascular-bed dependent diversity and activation
- 2016 - 2017 Elucidation of novel mechanism of phenotype synchronization among cardiomyocytes
- 2013 - 2017 Elucidation of pathogenesis and development of therapy of lipodystrophy using human iPS cell-derived adipocytes
- 2013 - 2016 Euro-Japan collaborative field work for the understanding of symbiotic evolution of marine microbes
- 2013 - 2016 Angiopoietin-1-mediated vascular development and maturation in the developing heart
- 2013 - 2016 Drug discovery for the treatment of severe heart failure
- 2012 - 2016 HCN4-luciferase knock-in mouse is a new tool for pacemaker cell reprogramming
- 2014 - 2015 Regulation of differentiation, regeneration, and homeostasis via signaling-epigenome interaction
- 2012 - 2015 Development of a novel vascular-targeting therapy through stem cell research
- 2012 - 2015 Screening and discovery of drug for severe heart failure with cardiac tissue sheet technology.
- 2013 - 2014 Analysis of stem cell differentiation process on the basis of epigenetic change
- 2013 - 2014 Novel humoral factors regulating epigenomic status
- 2011 - 2013 細胞分化機構から見た血管-神経共通シグナルの意義の解明
- 2012 - 2012 Novel mechanism regulating timing of cardiovascular cells with molecular linkage between PKA signaling and epigenome regulation
- 2012 - 2012 Cell therapy of adipocytes derived from human iPS cells using cellcontainers and animal disease models
- 2011 - 2011 Epigenetic regulation of "differentiation timing" of cardiovascular cells
- 2009 - 2011 Development of a novel"Seed and Soil"cardiac regenerative strategy with ES/iPS cells
- 2010 - 2010 心血管細胞分化の時間的制御に関与する新しい分子機構の解明
- 2008 - 2009 動静脈リンパ管特異的遺伝子を用いた新規多面的抗がん治療戦略の開発
- 2008 - 2009 新しいES細胞分化システムを用いた細胞分化におけるゲノム機能の系統的解析
- 2008 - 2009 誘導多能性幹(iPS)細胞を用いた新しい移植用心筋前駆細胞の開発
- 2007 - 2008 Development of comprehensive cardiac regeneration strategies with human ES cells
- 2006 - 2007 ES細胞を用いた包括的動静脈リンパ管分化多様化機構の解析
- 2006 - 2007 ES細胞を用いた新しい構成的発生生物学による分化におけるゲノム機能の網羅的解析
- 2005 - 2006 ES細胞を用いた新しい心筋前駆細胞の予見的同定法による心筋分化再生研究
- 2005 - 2006 Elucidation of significance of derangement of cell differentiation in metabolic syndrome ("cell mapping) and development of cell re-differentiation therapy using human ES cells
- 2005 - 2005 ES細胞を用いた動静脈リンパ管分化機構の解析
- 2004 - 2005 ヒトES細胞を用いたヒト発生および細胞分化解析システム
- 2004 - 2005 Development of selective induction system for functionally specified cardiomyocytes using embryonic stem cells
- 2004 - 2005 ヒトES細胞を用いた新しいヒト心血管分化誘導系の開発
- 2003 - 2005 再生内皮細胞移植ステントの開発研究
- 2004 - 2004 ES細胞を用いた心血管系発生における機能遺伝子の網羅的同定
- 2004 - 2004 ES細胞を用いた動静脈リンパ管特異的分化誘導系の構築と血管多様化機構の解析
- 2003 - 2004 ES細胞を用いた心筋幹/前駆細胞の同定と心筋分化再生への応用
- 2003 - 2004 Application of human ES-derived vascular progenitor cells to elucidation of vascular development/differentiation and vascular regeneration medicine
- 2000 - 2004 Production of cells that constitute microenvironment of cancer.
- 2003 - 2003 ES細胞を用いた哺乳動物における網羅的発生関連遺伝子機能解析
- 2002 - 2003 マウスES細胞in vitro血管分化系による血管発生分化の分子機構の解析
- 2003 - 2006 新規試験管内誘導システムによる分化再生研究
- 2003 - Study on cardiovascular differenciation and regenration using ES cells
- 1998 - 2000 血管平滑筋分化増殖制御に関与する新しい転写因子の分子医学的検討及び遺伝子治療応用
- 1998 - 血管発生の分子機構に関する研究
- 1998 - Study on molecular mechanism of vascular development
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Papers (203):
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Tomohiro Minakawa, Jun K. Yamashita. Versatile extracellular vesicle-mediated information transfer: intercellular synchronization of differentiation and of cellular phenotypes, and future perspectives. Inflammation and Regeneration. 2024. 44. 1
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Daisuke Heima, Masafumi Takeda, Yasuhiko Tabata, Kenji Minatoya, Jun K Yamashita, Hidetoshi Masumoto. Therapeutic potential of human induced pluripotent stem cell-derived cardiac tissue in an ischemic model with unloaded condition mimicking left ventricular assist device. The Journal of thoracic and cardiovascular surgery. 2023
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Tomohiro Minakawa, Jun K. Yamashita. Extracellular vesicles and microRNAs in the regulation of cardiomyocyte differentiation and proliferation. Archives of Biochemistry and Biophysics. 2023. 109791-109791
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川東 正英, 湊谷 謙司, 芦原 貴司, 山下 潤. Human iPS Cell-engineered Heart Tissue to Reproduce Ventricular Fibrillation in Vitro(タイトル和訳中). 日本循環器学会学術集会抄録集. 2023. 87回. OJ27-3
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Junko Yamane, Takumi Wada, Hironori Otsuki, Koji Inomata, Mutsumi Suzuki, Tomoka Hisaki, Shuichi Sekine, Hirokazu Kouzuki, Kenta Kobayashi, Hideko Sone, et al. StemPanTox: A fast and wide-target drug assessment system for tailor-made safety evaluations using personalized iPS cells. iScience. 2022. 25. 7. 104538-104538
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MISC (238):
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Regenerative medicine and stem cell biology in blood and lymphatic vessel development. 2017. 68. 4. 285-289
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Takeshi Ikuno, Hidetoshi Masumoto, Kohei Yamamizu, Miki Yoshioka, Kenji Minakata, Tadashi Ikeda, Ryuzo Sakata, Jun K. Yamashita. Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP (vol 12, e0173271, 2017). PLOS ONE. 2017. 12. 4
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K. Yamamizu, T. Ikuno, H. Takakubo, H. Masumoto, K. Minakata, Y. Tabata, J. K. Yamashita. Human iPS cell-engineered 3D-cardiovascular tissue by stacking sheets with gelatin hydrogel microspheres for cardiac regenerative medicine. EUROPEAN HEART JOURNAL. 2016. 37. 1211-1211
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H. Masumoto, M. Ishigami, T. Aoki, F. Takai, T. Ikuno, M. Kawatoh, K. Minakata, T. Ikeda, R. Sakata, J. Yamashita. Cardiac tissue sheet including human iPS cell-derived cardiomyocytes and vascular cells restores impaired left ventricular systolic function of infarcted porcine hearts: a preclinical study. EUROPEAN HEART JOURNAL. 2015. 36. 608-609
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Differentiation toward cardiovascular cell populations from human iPS cells. 2015. 252. 11. 1176-1180
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Education (4):
- - 1998 Kyoto University
- - 1998 Kyoto University Graduate School, Division of Medicine
- - 1990 Kyoto University Faculty of Medicine
- - 1990 Kyoto University Faculty of Medicine
Professional career (1):
- Doctor of Medicine (Kyoto University)
Work history (6):
Awards (9):
- 2018/08 - JST 日本ベンチャー学会会長賞
- 2016/08 - 内閣府 産学連携功労者表彰・ 日本学術会議会長賞
- 2010/03 - 日本心血管内分泌代謝学会 高峰譲吉研究奨励賞
- 2009/03 - Circulation, American Heart Association Best Paper Award 2008, Basic Science, Circulation
- 2002 - 成人血管病研究振興財団・岡本研究奨励賞
- 2000 - 日本血管細胞生物学会 YIA最優秀賞
- 2000 - 日本内分泌学会 若手研究者奨励賞
- 1997 - 日本循環器学会Young Investigator's Award
- 1995 - 日本動脈硬化学会学術奨励賞
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Association Membership(s) (9):
日本高血圧学会
, 日本内分泌学会
, 日本動脈硬化学会
, 日本循環器学会
, 日本内科学会
, 日本分子生物学会
, 日本血管生物医学会
, 日本炎症再生医学会
, 日本再生医療学会
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